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NICHOLAS SCHOOL FACULTY


Richard T Di Giulio

Publications  

Papers Published

  1. TT Lindberg, ES Bernhardt, R Bier, AM Helton, RB Merola, A Vengosh, RT Di Giulio, Cumulative impacts of mountaintop mining on an Appalachian watershed., Proceedings of the National Academy of Sciences of the United States of America, vol. 108 no. 52 (December, 2011), pp. 20929-34 [doi]  [abs].
  2. MR Wiesner, GV Lowry, E Casman, PM Bertsch, CW Matson, RT Di Giulio, J Liu, MF Hochella Jr, Meditations on the ubiquity and mutability of nano-sized materials in the environment., ACS nano, vol. 5 no. 11 (November, 2011), pp. 8466-70 [doi]  [abs].
  3. D Jung, CW Matson, LB Collins, G Laban, HM Stapleton, JW Bickham, JA Swenberg, RT Di Giulio, Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia., Ecotoxicology (London, England), vol. 20 no. 8 (November, 2011), pp. 1890-9 [doi]  [abs].
  4. BW Clark, RT Di Giulio, Fundulus heteroclitus adapted to PAHs are cross-resistant to multiple insecticides., Ecotoxicology (London, England) (October, 2011) [doi]  [abs].
  5. CR Fleming, RT Di Giulio, The role of CYP1A inhibition in the embryotoxic interactions between hypoxia and polycyclic aromatic hydrocarbons (PAHs) and PAH mixtures in zebrafish (Danio rerio)., Ecotoxicology (London, England), vol. 20 no. 6 (August, 2011), pp. 1300-14 [doi]  [abs].
  6. LA Van Tiem, RT Di Giulio, AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE- and ARE-associated gene induction in zebrafish (Danio rerio)., Toxicology and applied pharmacology, vol. 254 no. 3 (August, 2011), pp. 280-7 [doi]  [abs].
  7. EM Cooper, HM Stapleton, CW Matson, RT Di Giulio, AJ Schuler, Ultraviolet treatment and biodegradation of dibenzothiophene: Identification and toxicity of products., Environmental toxicology and chemistry / SETAC, vol. 29 no. 11 (November, 2010), pp. 2409-16 [doi]  [abs].
  8. LP Wills, D Jung, K Koehrn, S Zhu, KL Willett, DE Hinton, RT Di Giulio, Comparative chronic liver toxicity of benzo[a]pyrene in two populations of the atlantic killifish (Fundulus heteroclitus) with different exposure histories., Environmental health perspectives, vol. 118 no. 10 (October, 2010), pp. 1376-81 [doi]  [abs].
  9. BW Clark, CW Matson, D Jung, RT Di Giulio, AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic killifish (Fundulus heteroclitus)., Aquatic toxicology (Amsterdam, Netherlands), vol. 99 no. 2 (August, 2010), pp. 232-40 [doi]  [abs].
  10. LP Wills, CW Matson, CD Landon, RT Di Giulio, Characterization of the recalcitrant CYP1 phenotype found in Atlantic killifish (Fundulus heteroclitus) inhabiting a Superfund site on the Elizabeth River, VA., Aquatic toxicology (Amsterdam, Netherlands), vol. 99 no. 1 (August, 2010), pp. 33-41 [doi]  [abs].
  11. SE Hunter, D Jung, RT Di Giulio, JN Meyer, The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number., Methods (San Diego, Calif.), vol. 51 no. 4 (August, 2010), pp. 444-51 [doi]  [abs].
  12. Jung, Dawoon and Di Giulio, Richard T., Identification of mitochondrial cytochrome P450 induced in response to polycyclic aromatic hydrocarbons in the mummichog (Fundulus heteroclitus), COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, vol. 151 no. 1 (January, 2010), pp. 107-112 [doi]  [abs].
  13. Il'yasova, D., I. Spasojevich, F. Wang, A. A. Tolun, K. Base, S.P. Young, P.K. Marcom, J. Marks, G. Mixon, R. DiGiulio, and D.S. Millington, Urinary biomarkers of oxidative status in a clinical model of oxidative assault, Cancer Epidemiology Biomarkers and Prevention, vol. 19 (2010), pp. 1506-1510 .
  14. Jung, Dawoon and Cho, Youngeun and Collins, Leonard B. and Swenberg, James A. and Di Giulio, Richard T., Effects of benzo{[}a]pyrene on mitochondrial and nuclear DNA damage in Atlantic killifish (Fundulus heteroclitus) from a creosote-contaminated and reference site, AQUATIC TOXICOLOGY, vol. 95 no. 1 (October, 2009), pp. 44-51 [doi]  [abs].
  15. Wiesner, Mark R. and Lowry, Gregory V. and Jones, Kimberly L. and Hochella, Jr., Michael F. and Di Giulio, Richard T. and Casman, Elizabeth and Bernhardt, Emily S., Decreasing Uncertainties in Assessing Environmental Exposure, Risk, and Ecological Implications of Nanomaterials, ENVIRONMENTAL SCIENCE & TECHNOLOGY, vol. 43 no. 17 (September, 2009), pp. 6458-6462 [doi] .
  16. Fleming, Carrie R. and Billiard, Sonya M. and Di Giulio, Richard T., Hypoxia inhibits induction of aryl hydrocarbon receptor activity in topminnow hepatocarcinoma cells in an ARNT-dependent manner, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, vol. 150 no. 3 (September, 2009), pp. 383-389 [doi]  [abs].
  17. Timme-Laragy, Alicia R. and Van Tiem, Lindsey A. and Linney, Elwood A. and Di Giulio, Richard T., Antioxidant Responses and NRF2 in Synergistic Developmental Toxicity of PAHs in Zebrafish, TOXICOLOGICAL SCIENCES, vol. 109 no. 2 (June, 2009), pp. 217-227 [doi]  [abs].
  18. Wills, Lauren P. and Zhu, Shiqian and Willett, Kristine L. and Di Giulio, Richard T., Effect of CYP1A inhibition on the biotransformation of benzo{[}a]pyrene in two populations of Fundulus heteroclitus with different exposure histories, AQUATIC TOXICOLOGY, vol. 92 no. 3 (May, 2009), pp. 195-201 [doi]  [abs].
  19. Jung, Dawoon and Cho, Youngeun and Meyer, Joel N. and Di Giulio, Richard T., The long amplicon quantitative PCR for DNA damage assay as a sensitive method of assessing DNA damage in the environmental model, Atlantic killifish (Fundulus heteroditus), COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, vol. 149 no. 2, Sp. Iss. SI (March, 2009), pp. 182-186 [doi]  [abs].
  20. Il'yasova, D., G. Mixon, F. Wang, J. Marks, I. Spasojevich, N. Crafft, F. Arredondo, and R. Di Giulio, Epidemiological markers of oxidative stress: pilot validation study, Bioamrkers 14:321-325. (2009) .
  21. Timme-Laragy, A.R., P.D. Noyes, D.R. Buhler, and R.T. Di Giulio, CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio), Marine Environmental Research, vol. 66 no. 85-87 (2008) .
  22. Matson, C.W., A.R. Timme-Laragy, and R.T. Di Giulio, Fluoranthene, but not benzo[a]pyrene, interacts with hypoxia resulting in pericardial effusion and lordosis in developing zebrafish, Chemosphere, vol. 74 (2008), pp. 149-154 .
  23. Matson, C.W., B.W. Clark, M.J. Jenny, C.R. Fleming, M.E. Hahn, and R.T. Di Giulio, Development of the morpholino gene knockdown technique in Fundulus heteroclitus: a tool for studying molecular mechanisms in an established environmental model, Aquatic Toxicol, vol. 87 (2008), pp. 289-295 .
  24. Larose, C., R. Canuel, M. Lucotte, P. Spear, and R.T. Di Giulio, Toxicological effects of methylmercury on walleye (Sander vitreus) and perch (Perca flavescens) from lakes of the boreal forest, Comparative Biochem & Physiol, vol. 147C (2008), pp. 139-149 .
  25. Bohonowych, J.E.S., B. Zhao, A. Timme-Laragy, D. Jung, R.T. Di Giulio, and M.S. Denison, Newspapers and newspaper inks contain agonists for the AH receptor, Toxicological Sciences, vol. 102 (2008), pp. 278-290 .
  26. Billiard, S.M., Meyer, J.N., Wassenberg, D.M., Hodson, P.V., and Di Giulio, R.T., Nonadditive effects of PAHs on early vertebrate development: mechanisms and implications for risk assessment, Toxicological Sciences, vol. 105 (2008), pp. 5-23 .
  27. Augspurger, T.P., D.E. Tillitt, S.J. Bursian, S.D. Fitzgerald, D.E. Hinton, and R.T. Di Giulio, Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the wood duck (Aix sponsa), Archives of Environmental Contamination and Toxicology, vol. 55 (2008), pp. 659-669 .
  28. Augspurger, T.P. K.R. Echols, P.H. Peterman, T.W. May, C.E. Orazio, D.E. Tillitt, and R.T. Di Giulio, Accumulation of environmental contaminants in wood duck (Aix sponsa) eggs with emphasis on 2,3,7,,8-tetrachlordibenzo-p-dioxin equivalents, Archives of Environmental Contamination and Toxicology, vol. 55 (2008), pp. 670-682 .
  29. Timme-Laragy, A.R., C.J. Cockman, C.W. Matson, and R.T. Di Giulio, Synergistic upregulation of AHR regulated genes in developmental toxicity of a polycyclic aromatic hydrocarbon mixture to zebrafish, Aquatic Toxicology (In press) .
  30. Rau Embry, M., S.M. Billiard, and R.T. Di Giulio, Lack of p53 induction in fish cells by model chemotherapeutics, Oncogene, vol. 25 (2006), pp. 2004-2010 .
  31. Billiard, S., A.R. Timme-Laragy, D.M. Wassenberg, C.Cockman, and R.T. Di Giulio, The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish, Toxicological Sciences, vol. 92 (2006), pp. 526-536 .
  32. Wassenberg, D., A. Nerlinger, L.Battle, and R.T. Di Giulio, Effects of the PAH-heterocycles, carbazole and dibenzothiophene, on invivo and invitro CYP1A activity and PAH-derived embryotoxicity, Environmental Toxicology and Chemistry, vol. 24 (2005), pp. 2526-2532 .
  33. Timme-Laragy, A.R., J.N. Meyer, R.A. Waterland, and R.T. Di Giulio, Analysis of CpG methylation in the killifish CYP1A promoter, Comparative Biochemistry and Physiology, Part C, vol. 141 (2005), pp. 406-411 .
  34. Meyer, J.N., D.C. Volz, J.H. Freedman, and R.T. Di Giulio, Differential display of hepatic mRNA from killifish (Fundulus heteroclitus) inhabiting a Superfund estuary, Aquatic Toxicology, vol. 73 (2005), pp. 327-341 .
  35. Wassenberg, D.M., and R.T. Di Giulio, Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus, Environmental Health Perspectives, vol. 112 (2004), pp. 1658-1664 .
  36. Wassenberg, D.M., and R.T. Di Giulio, Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors, Marine Environmental Research, vol. 58 (2004), pp. 163-168 .
  37. Bacanskas, L.R., J. Whitaker, and R.T. Di Giulio, Oxidative stress in two populations of killifish (Fundulus heteroclitus) with differing contaminant exposure histories, Marine Environmental Research, vol. 58 (2004), pp. 597-601 .
  38. Rau, M.A., J. Whitaker, J.H. Freedman, and R.T. Di Giulio, Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants, Comparative Biochemistry and Physiology, vol. 137C (2004), pp. 335-342 .
  39. Meyer, J.N., and R.T. Di Giulio, Genetic adaptation and associated fitness tradeoffs in killifish (Fundulus heteroclitus) inhabiting a contaminated estuary, Ecological Applications, vol. 13 (2003), pp. 490-503 .
  40. Meyer, J.N., D.M. Wassenberg, S.I. Karchner, M.E. Hahn, and R.T. Di Giulio, Expression and inducibility of aryl hydrocarbon receptor (AHR) pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories, Environmental Toxicology and Chemistry, vol. 22 (2003), pp. 2337-2343 .
  41. Meyer, J.N., J.D. Smith, G.W. Winston, and R.T. Di Giulio, Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses, Aquatic Toxicology, vol. 65 (2003), pp. 377-395 .
  42. Meyer, J.N., D. Nacci, and R.T. Di Giulio, Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments, Toxicological Sciences, vol. 68 (2002), pp. 69-81 .
  43. Meyer, J., and R. Di Giulio, Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA., Marine Environmental Research, vol. 54 (2002), pp. 621-626 .
  44. Wassenberg, D., E. Swails, and R. Di Giulio, Effects of combined exposures to benzo[a]pyrene and 3,3',4,4',5-pentachlorobiphenyl on Fundulus heteroclitus, Marine Environmental Research, vol. 54 (2002), pp. 279-283 .

Papers Accepted

  1. Jung, D., Y. Cho, J.N. Meyer, and R.T. Di Giulio, The long amplicon quantitative PCR for DNA damage assay as a sensitive method of assessing DNA damage in the environmental model, Atlantic killifish (Fundulus heteroclitus), Comparative Biochem & Physiol, vol. in press (2008) [007] .
  2. Timme-Laragy, A.R., L.A. Van Tiem, and R.T. Di Giulio, Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish, Toxicological Sciences, vol. accepted (2008) .
  3. Battle, L.P., S. Zhu, K.L. Willett, and R.T. Di Giulio, Effect of the CYP1A inhibitor fluoranthene on the biotransformation of benzo[a]pyrene in two populations of Fundulus heteroclitus with different exposure histories, Aquatic Toxicol, vol. accepted (2008) .

Books Published

  1. Di Giulio, R.T., and D.E. Hinton, The Toxicology of Fishes (2008), CRC Press, Taylor and Francis Group .
  2. Genomic Approaches for Cross-Species Extrapolations in Toxicology, edited by Benson, W.H., and R.T. Di Giulio (2007), Taylor and Francis, New York .
  3. The Toxicology of Fishes, edited by Di Giulio, R.T., and D.E. Hinton (In Press), Taylor and Francis, New York .
  4. Interconnections between Human Health and Ecological Integrity, edited by Di Giulio, R.T., and W.H. Benson (2002), SETAC Press, Pensacola, FL. .
  5. Reproductive and Developmental Effects of Contaminants in Oviparous Vertebrates, edited by Di Giulio, R.T., and D.E. Tillitt (1999), SETAC Press, Pensacola, FL .
  6. Interconnections Between Human and Ecosystem Health, edited by Di Giulio, R.T., and E. Monosson (1996), Chapman and Hall, London .

Book Chapters

  1. Di Giulio, R.T. and M.C. Newman, Ecotoxicology, in Casarett and Doull's Toxicology. The Basic Science of Poisons, edited by Klaassen, C.D. (2008), McGraw Hill .
  2. Rotchell, J.M., D.E. Hinton, M.R. Miller, R.T. Di Giulio, and G.K. Ostrander, Chemical carcinogenesis in fishes, in The Toxicology of Fishes, edited by Di Giulio and Hinton (2008), pp. 531-598, CRC .
  3. Di Giulio, R.T. and J.N. Meyer, Reactive oxygen species and oxidative stress, in The Toxicology of Fishes, edited by Di Giulio, R.T., and D.E. Hinton (2008), pp. 273-324, CRC .
  4. R.T. Di Giulio and M.C. Newman, Ecotoxicology, in Klaassen, C.D., ed. Casarett and Doull's Toxicology. The Basic Science of Poisons, 6th edition (In Press), McGraw-Hill .
  5. R.T. Di Giulio and J.N. Meyer, Reactive oxygen species and oxidative stress, in Di Giulio, R.T., andD.E. Hinton, eds. The Toxicology of Fishes (In Press), Taylor and Francis, New York .
  6. Rotchell, J.M., D.E. Hinton, M.R. Miller, R.T. Di Giulio and G.K. Ostrander, Chemical carcinogenesis in fishes, in Di Giulio, R.T., and D.E. Hinton, eds. The Toxicology of Fishes (In Press), Taylor and Francis, New York .
  7. Nacci, D., L. Coiro, D.M. Wassenberg, and R.T. Di Giulio, A non-destructive technique to measure cytochrome P4501A enzyme activity in living embryos of the estuarine fish Fundulus heteroclitus, in Techniques in Aquatic Toxicology, edited by Ostrander, G.K., vol. 2 (2005), pp. 209-226, CRC Press, Boca Raton, FL. .
  8. Schlenk, D., and R.T. Di Giulio, Biochemical responses as indicators of aquatic ecosystem health, in Biological Indicators of Aquatic Ecosystem Stress, edited by S.M. Adams (2002), pp. 13-422, American Fisheries Society, Bethesda, MD. .

 

Contact Richard T Di Giulio

A346B LSRC
Box 90328
Durham, NC 27708
(919) 613-8024
fax: (919) 668-1799
richd@duke.edu


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