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NICHOLAS SCHOOL FACULTY


Heather M. Stapleton

Publications  

Papers Published

  1. W Dong, LJ Macaulay, KW Kwok, DE Hinton, HM Stapleton, Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages., Aquatic toxicology (Amsterdam, Netherlands), vol. 132-133 (May, 2013), pp. 190-9  [abs].
  2. M Fang, TF Webster, D Gooden, EM Cooper, MD McClean, C Carignan, C Makey, HM Stapleton, Investigating a novel flame retardant known as V6: measurements in baby products, house dust, and car dust., Environ Sci & Technol, vol. 47 no. 9 (May, 2013), pp. 4449-54  [abs].
  3. HB Patisaul, SC Roberts, N Mabrey, KA McCaffrey, RB Gear, J Braun, SM Belcher, HM Stapleton, Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment., Journal of biochemical and molecular toxicology, vol. 27 no. 2 (February, 2013), pp. 124-36  [abs].
  4. Allen, J.G., Stapleton, H.M. Vallerino, J., McNeely, E., McClean, M.D., Harrad, S.J., Rauert, C., Spengler, J.D., Exposure to flame retardant chemicals on commercial airplanes., Environmental Health (2013) .
  5. Carignan, C., McClean, M.D., Cooper, E., Watkins, D., Fraser, A., Heiger-Bernays,W., Stapleton, H.M. Webster, T.F., Predictors of Tris-(1,3-dichloro-2-propyl) phosphate Metabolite in the Urine of Office Workers, Environment International (2013) .
  6. Slotkin, T.A., Cooper, E.M., Stapleton, H.M., Seidler, F.J., Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?, Environmental Toxicology & Pharmacology (2013) .
  7. Meeker, J.D., Cooper, E.M., Stapleton, H.M. Hauser, R., Urinary metabolites of organophosphate flame retardants: Temporal variability and correlations with house dust concentrations., Environmental Health Perspectives (2013) .
  8. McGee, S.P., Konstantinov, A., Stapleton, H.M., Volz, D.C., Aryl phosphate esters within a major PentaBDE Replacement Product Induce Cardiotoxicity in Developing Zebrafish Embryos: Potential role of the aryl hydrocarbon receptor., Toxicological Sciences (2013) .
  9. Watkins, D.J., McClean, M.D., Frasier, A.J., Weinberg, J., Stapleton, H.M., Webster, T.F., Associations between PBDEs in office air, dust, and surface wipes., Environment International (2013) .
  10. Webster, T.F., Stapleton, H.M., McClean, M.D., Exposure to Polybrominated Diphenyl Ethers in Indoor Environments., Fire Technology (2013) .
  11. Lohman, R., Stapleton, H.M., Hites, R.A., Science Should Guide TSCA Reform., Environ Sci & Technol (2013) .
  12. Noyes, P.D., Lema, S.C., Macaulay, L.J., Douglas, N.K., and Stapleton, H.M., Low Level Exposure to the Flame Retardant BDE-209 Reduces Thyroid Hormone Levels and Disrupts Thyroid Signaling in Fathead Minnows., Environ Sci & Technol (2013) .
  13. Clark, B., Cooper, E.M., Stapleton, H.M. Di Giulio, R.D., Compound- and mixture-specific differences in resistance to PAHs and PCB-126 among Fundulus heteroclitus subpopulations throughout the Elizabeth River estuary (Virginia, USA)., Environ Sci & Technol (2013) .
  14. Meeker, J., Cooper, E.M. Stapleton, H.M. Hauser, R.D., Exploratory analysis of urinary metabolites of phosphorus-containing flame retardants in relation to markers of male reproductive health., Endocrine Disruptors (2013) .
  15. Muzzio, A.M., Noyes, P.D., Stapleton, H.M., Lema S.C., Tissue distribution and thyroid hormone effects on mRNA abundance for membrane transporters Mct8, Mct10, and organic anion-transporting polypeptides (Oatps) in a teleost fish., Comparative Biochem & Physiol (2013) .
  16. Butt, C.M., Stapleton, H.M., Inhibition of thyroid hormone sulfotransferase activity by brominated flame retardants and halogenated phenolics., Chemical Research in Toxicology (2013) .
  17. Levin, E.D., Cauley, M., Johnson, J., Cooper, E.M., Stapleton, H.M., Ferguson, P.L., Seidler, F.J., Slotkin, T.A., Prenatal Dexamethasone Augments the Neurobehavioral Teratology of Chlorpyrifos: Significance for Maternal Stress and Preterm Labor., Neurotoxicology and Teratology (2013) .
  18. Carignan, C.C., Heiger-Bernays, W., McClean, M.D., Roberts, S.C., Stapleton, H.M., Sjodin, A., and Webster, T.F., Flame Retardant Exposure among Collegiate US Gymnasts., Environ Sci & Technol (2013) .
  19. McClain, V, Stapleton, H.M., Tilton F., Gallagher, E.P., BDE 49 and Developmental Toxicity in Zebrafish., Comparative Biochem & Physiol C, vol. 155 no. 2 (2012), pp. 253-258 .
  20. Ashley, J.T.F., Vasquez, M.A., Zelanko, P., McKinley, E., Schafer, M., Zaoudeh, L., Horwitz, R., Stapleton, H.M., Velinsky, D.J., Trophic Transfer of Polybrominated Diphenyl Ethers and Polychlorinated Biphenyls in a Tidal Freshwater Marsh., Chemistry & Ecology, vol. 28 no. 4 (2012), pp. 305-325 .
  21. Bearr, J.S., Mitchelmore, C.L., Roberts, S.C., Stapleton. H.M., Species specific differences in the in vitro metabolism of the flame retardant mixture, Firemaster® BZ 54., Aquatic Toxicol, vol. 124-125 (2012), pp. 41-47 .
  22. Roberts, S.C., Macaulay, L.J., Stapleton, H.M., . In Vitro Metabolism of the Brominated Flame Retardants 2-ethylhexyl-2,3,4,5 tetrabromobenzoate (TBB) and Bis-2-ethylhexyl-2,3,4,5 tetrabromophthalate (TBPH) in Human and Rat Tissues., Chemical Research in Toxicology, vol. 25 no. 7 (2012), pp. 1435-1441 .
  23. Klosterhaus, S., Stapleton, H.M., LaGuardia, M.J., Greig, D.J., Brominated and Chlorinated Flame Retardants in San Francisco Bay Sediments and Wildlife., Environment International, vol. 47 no. 56-65 (2012) .
  24. McGee, S.P.,Cooper, E., Stapleton H.M., D. Volz., Early Zebrafish Embryogenesis Is Susceptible to Developmental TDCPP Exposure, Environmental Health Perspectives, vol. 120 no. 11 (2012), pp. 1586-1591 .
  25. Springer, C. Dere, E., Hall, S.J., McDonnell, E.V., Roberts, S.C., Butt, C.M., Stapleton, H.M. , Watkins, D.J., McClean, M.D., Webster, T.F., Schlezinger, J.J., and Boekelheide, K, Rodent Thyroid, Liver, and Fetal Testis Toxicity of the Monoester Metabolite Bis- (2-ethyhexyl) Tetrabromophthalate (TBPH), A Novel Brominated Flame Retardant Present in Indoor Dust., Environmental Health Perspectives, vol. 120 no. 12 (2012), pp. 1711-1719 .
  26. Stapleton, H.M. Sharma, S., Getzinger, G., Ferguson, P.L., Gabriel, M, Webster, T.F., Blum, A., Novel and High Volume Use Flame Retardants in US Couches Reflective of the 2005 PentaBDE Phase Out., Environ Sci & Technol, vol. 46 no. 24 (2012), pp. 13432-13439 .
  27. Buttke, D.E., Wolkin, A., Stapleton, H.M., Miranda, M.L., Associations between serum levels of Polybrominated Diphenyl Ether (PBDE) flame retardants and environmental and behavioral factors in pregnant women., Journal of Exposure Science and Environmental Epidemiology (2012) .
  28. D. J. Watkins, M.D. Mclean, A. J. Fraser, J. Weinberg, H.M. Stapleton, A. Sjodin, and T.F. Webster, Impact of Dust from Multiple Microenvironments and Diet on PentaBDE Body Burden, Environ Sci & Technol, vol. 46 no. 2 (2012), pp. 1192-1200 .
  29. H.M. Stapleton, S.D. Eagle, A. Sjodin, and T.F. Webster, Serum PBDEs in US Toddlers: Associations with Hand Wipes, House Dust and Socioeconomic Variables, Environmental Health Perspectives, vol. 120 no. 7 (2012), pp. 1049-1054 .
  30. Elizabeth F. Davis, Susan L. Klosterhaus, Heather M. Stapleton, Measurement of Flame Retardants and Triclosan in Municipal Sewage Sludge and Biosolids, Environment International, vol. 40 (2012), pp. 1-7 .
  31. Alicia J Frasera, Thomas F Webstera, Deborah J Watkinsa, Jessica W Nelsona, Heather M Stapletonb, Antonia M Calafatc, Kayoko Katoc, Mahiba Shoeibd, Verónica M Vieraa, Michael D McClean, Polyfluorinated Compounds in Serum Linked to Indoor Air in Office Environments, Environ Sci & Technol, vol. 46 no. 2 (2012), pp. 1209-1215 .
  32. Tomy, Gregg T. and Palace, Vince and Marvin, Chris and Stapleton, Heather M. and Covaci, Adrian and Harrad, Stuart, Biotransformation of HBCD in Biological Systems Can Confound Temporal-Trend Studies, Environmental Science & Technology, vol. 45 no. 2 (2011), pp. 364-365 .
  33. Stapleton, Heather M. and Klosterhaus, Susan and Keller, Alex and Ferguson, P. Lee and van Bergen, Saskia and Cooper, Ellen and Webster, Thomas F. and Blum, Arlene, Identification of Flame Retardants in Polyurethane Foam Collected from Baby Products, Environmental Science & Technology, vol. 45 no. 12 (2011), pp. 5323-5331 .
  34. Cooper, E. M. and Covaci, A. and van Nuijs, A. L. N. and Webster, T. F. and Stapleton, H. M., Analysis of the flame retardant metabolites bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPP) in urine using liquid chromatography-tandem mass spectrometry, Analytical and Bioanalytical Chemistry, vol. 401 no. 7 (2011), pp. 2123-2132 .
  35. Dishaw, Laura V. and Powers, Christina M. and Ryde, Ian T. and Roberts, Simon C. and Seidler, Frederic J. and Slotkin, Theodore A. and Stapleton, Heather M., Is the PentaBDE replacement, tris (1,3-dichloropropyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells, Toxicology and Applied Pharmacology, vol. 256 no. 3 (2011), pp. 281-289 .
  36. Jung, Dawoon and Matson, Cole W. and Collins, Leonard B. and Laban, Geoff and Stapleton, Heather M. and Bickham, John W. and Swenberg, James A. and Di Giulio, Richard T., Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia, Ecotoxicology (London, England), vol. 20 no. 8 (2011), pp. 1890-9 .
  37. Noyes, Pamela D. and Hinton, David E. and Stapleton, Heather M., Accumulation and Debromination of Decabromodiphenyl Ether (BDE-209) in Juvenile Fathead Minnows (Pimephales promelas) Induces Thyroid Disruption and Liver Alterations, Toxicological Sciences, vol. 122 no. 2 (2011), pp. 265-274 .
  38. Watkins, Deborah J. and McClean, Michael D. and Fraser, Alicia J. and Weinberg, Janice and Stapleton, Heather M. and Sjoedin, Andreas and Webster, Thomas F., Exposure to PBDEs in the Office Environment: Evaluating the Relationships Between Dust, Handwipes, and Serum, Environmental Health Perspectives, vol. 119 no. 9 (2011), pp. 1247-1252 .
  39. Roberts, Simon C. and Noyes, Pamela D. and Gallagher, Evan P. and Stapleton, Heather M., Species-Specific Differences and Structure-Activity Relationships in the Debromination of PBDE Congeners in Three Fish Species, Environmental Science & Technology, vol. 45 no. 5 (2011), pp. 1999-2005 .
  40. Stapleton, Heather M. and Eagle, Sarah and Anthopolos, Rebecca and Wolkin, Amy and Miranda, Marie Lynn, Associations between Polybrominated Diphenyl Ether (PBDE) Flame Retardants, Phenolic Metabolites, and Thyroid Hormones during Pregnancy, Environmental Health Perspectives, vol. 119 no. 10 (2011), pp. 1454-1459 .
  41. Butt, C.M., Wang, D., Stapleton, H.M, Halogenated Phenolic Contaminants Inhibit the In Vitro Activity of the Thyroid Regulating Deiodinases in Human Liver, Toxicological Sciences, vol. 124 no. 2 (2011), pp. 339-347 .
  42. Bearr, J.S., Stapleton, H.M., Mitchelmore, C.M, Accumulation and DNA Damage in Pimephales promelas Exposed to Two Brominated Flame Retardant Mixtures, Firemaster 550 and Firemaster BZ-54, Environmental Toxicology & Chemistry, vol. 29 no. 3 (2010), pp. 722-729 .
  43. Noyes, P.D., Kelly, S.M., Mitchelmore, C.L., Stapleton, H.M., Characterizing the In Vitro Biotransformation of the Flame Retardant BDE 99 by Common Carp, Aquatic Toxicol, vol. 97 (2010), pp. 142-150 .
  44. Meeker, J.D., Stapleton, H.M., House Dust Concentrations of Organophosphate Flame Retardants in Relation to Hormone Levels and Semen Quality Parameters, Environmental Health Perspectives, vol. 118 no. 3 (2010), pp. 318-323 .
  45. Kim, G.B., Stapleton, H.M., PBDEs, Methoxylated PBDEs and HBCDs in Japanese Common Squid (Todarodes pacificus) from Korean Offshore Waters, Marine Pollution Bulletin, vol. 60 (2010), pp. 935-940 .
  46. Wang, Dongli, Stapleton, H.M., Analysis of Thyroid Hormones in Serum by Liquid Chromatography Tandem Mass Spectrometry., Analytical & Bioanalytical Chemistry, vol. 397 (2010), pp. 1831-1839 .
  47. Ashley, J.T.F., Ward, J.S., Schafer, M.W., Stapleton, H.M., Velinsky, D.J, Evaluating Daily Exposure to Polychlorinated Biphenyls and Polybrominated Diphenyl Ethers in Fish Oil Supplements., Food Additives and Contaminants: Part A, vol. 27 no. 8 (2010), pp. 1177-1185 .
  48. Johnson, P.J., Stapleton, H.M., Sjodin, A., Meeker, J.D., Relationships between Polybrominated Diphenyl Ether Concentrations in House Dust and Serum, Environ Sci & Technol, vol. 44 no. 14 (2010), pp. 5627-5632 .
  49. Cooper, E.M., Stapleton, H.M., Matson, C.W., Di Giulio, R.D., Schuler, A.J, Ultraviolet Treatment and Biodegradation of Dibenzothiopene: Identfication and Toxicity of Products, Environmental Toxicology & Chemistry, vol. 29 no. 11 (2010), pp. 2409-2416 .
  50. Stapleton, H.M., Klosterhaus, S., Eagle, S., Fuh, J., Meeker, J.D., Blum, A., Webster, T.F, Detection of Organophosphate Flame Retardants in Furniture Foam and U.S. House Dust., Environ Sci & Technol (October, 2009) .
  51. Davis, E., Stapleton, H.M., Photodegradation Pathways of Nonabrominated Diphenyl Ethers, 2-Ethylhexyltetrabromobenzoate, and Di(2-ethylhexyl)tetrabromophthalate: Identifying Potential Markers of Photodegradation, Environ Sci & Technol (August, 2009) .
  52. Webster, T.F., Harrad, S., Millette, J.R., Holbrook, R.D., Davis, J. M., Stapleton, H.M., Allen, J.G., McClean, M.D., Ibarra, C., Abdallah, M.A., Covaci, A., Identifying transfer mechanisms and sources of decabromodiphenyl ether (BDE 209) in indoor environments using environmental forensic microscopy, Environ Sci & Technol (May, 2009) .
  53. Brown, E.P., Stapleton, H.M., Kelly, S., Tilton, S.C., Gallagher, E.P, In Vitro Hepatic Metabolism of 2,2’,4,4’,5-pentabromodiphenyl ether (BDE 99) in Chinook Salmon (Onchorhynchus tshawytscha), Aquatic Toxicol (May, 2009) .
  54. Stapleton, H.M. Kelly, S.M., Pei, R., Letcher, R.J., Gunsch, C.K., Metabolism of Polybrominated Diphenyl Ethers (PBDEs) By Human Hepatocytes In vitro, Environmental Health Perspectives (February, 2009), (in press) .
  55. Allen, J.G., McClean, M.D., Stapleton, H.M., Webster, T.F, Longitudinal Analysis of Polybrominated Diphenyl Ethers (PBDEs) in Household Microenvironments: Characterization of Dust and Relationship to Indoor Air., Environment International, vol. 34 no. 8 (2008), pp. 1085-1091 .
  56. Allen, J.G., McClean, M.D., Stapleton, H.M., Webster, T.F, Linking PBDEs in House Dust to Consumer Products using X-Ray Fluorescence (XRF), Environmental Science & Technology, vol. 42 no. 11 (2008), pp. 4222-4228 .
  57. Huwe, J.K., Hakk, H., Smith, D.J., Diliberto, J.J., Richardson, V., Stapleton, H.M., Birnbaum, L.S., Comparative Absorption and Bioavailability of Polybrominated Diphenyl Ethers Following Ingestion Via Dust and Oil in Male Rats., Environmental Science & Technology, vol. 42 no. 7 (2008), pp. 2694-2700 .
  58. Stapleton, H.M., Sjodin, A., Jones, R.S., Niehauser, S., Zhang, Y., Patterson, D.G., Serum PBDE Levels in Occupationally Exposed Individuals in the United States, Environ Sci & Technol, vol. 42 no. 9 (2008), pp. 3453-3458 .
  59. Stapleton, H.M., Kelly, S.M., Allen, J.G., McClean, M.D., Webster, T.F., Measurement of Polybrominated Diphenyl Ethers on Hand Wipes: Estimating Exposure from Hand to Mouth Contact, Environ Sci & Technol, vol. 49 no. 9 (2008), pp. 3329-3334 .
  60. Stapleton, H.M., and Dodder, Nathan G., Photodegradation of Decabromodiphenyl Ether (BDE 209) in House Dust by Natural Sunlight, Environmental Chemistry & Toxicology, vol. 27 no. 2 (2008), pp. 306-312 .
  61. Stapleton,. H.M., Allen, J.G., Kelly, S.M., Konstantinov, A., Klosterhaus, S., Watkins, D., McClean, M.D., Webster, T.F., Alternate and New Brominated Flame Retardants Detected in U.S. House Dust, Environmental Science & Technology, vol. 42 no. 18 (2008), pp. 6910-6916, American Chemical Society .
  62. H.M Stapleton, N.G. Dodder, J.H. Offenberg, M.M. Schantz & S.A. Wise, Polybrominated Diphenyl Ethers in House Dust and Clothes Dryer Lint, Environ. Sci. Technol., vol. 39 no. 4 (2005), pp. 925-931 .
  63. H.M. Stapleton, M. Alaee, R.J. Letcher & J.E. Baker, Debromination of the flame retardant decabromodiphenyl ether by juvenile carp (Cyprinus carpio) following dietary exposure, Environ. Sci. Technol., vol. 38 no. 1 (2003), pp. 112-119 .
  64. H.M Stapleton, R.J. Letcher & J.E. Baker, Dietary accumulation and metabolism of polybrominated diphenyl ethers (PBDEs) by juvenile carp (Cyprinus carpio), Environ. Contam. Toxicol., vol. 23 no. 8 (2003), pp. 1939-1946 .
  65. H.M. Stapleton, C. Masterson, J. Skubinna, P. Ostrom, N.E. Ostrom & J.E. Baker, Accumulation of atmospheric and sedimentary PCBs and toxaphene in a Lake Michigan food web, Environ. Sci. Technol., vol. 35 no. 16 (2001), pp. 3287-3293 .
  66. H.M. Stapleton, R.J. Letcher & J.E. Baker, Metabolism of highly chlorinated PCBs by a Lake Michigan fish, Environ. Sci. Technol., vol. 35 no. 24 (2001), pp. 4747-4752 .

Papers Accepted

  1. Hoffman, K., Daniels, J.L., Stapleton. H.M., Urinary Metabolites of Organophosphate Flame Retardants and Their Variability in Pregnant Women, Environment International (2013) .
  2. Noyes, P.D., Lema, S.C., Roberts, S.C., Cooper, E.M., and Stapleton. H.M., A Rapid Method for the Measurement of Circulating Thyroid Hormones in Low Volumes of Teleost Fish Plasma by LC-ESI/MS/MS., Analytical & Bioanalytical Chemistry (2013) .
  3. Stapleton, H.M., Misenheimer, J.C., Hoffman, K., and Webster. T.F., Flame Retardant Associations Between Children's Handwipes and House Dust, Chemosphere (2013) .
  4. Johnson, P.J., Stapleton, H.M., Mukherjee, B., Hauser, R., Meeker, J.D, Associations between brominated flame retardants in house dust and hormone levels in men., Sci Total Environ (2012) .
  5. D. J. Watkins, M.D. Mclean, A. J. Fraser, J. Weinberg, H.M. Stapleton, A. Sjodin, and T.F. Webster, Impact of Dust from Multiple Microenvironments and Diet on PentaBDE Body Burden, Environ Sci & Technol (2011) .
  6. Alicia J Frasera, Thomas F Webstera, Deborah J Watkinsa, Jessica W Nelsona, Heather M Stapletonb, Antonia M Calafatc, Kayoko Katoc, Mahiba Shoeibd, Verónica M Vieraa, Michael D McClean, Polyfluorinated Compounds in Serum Linked to Indoor Air in Office Environments, Environ Sci & Technol (2011) .
  7. Elizabeth F. Davis, Susan L. Klosterhaus, Heather M. Stapleton, Measurement of Flame Retardants and Triclosan in Municipal Sewage Sludge and Biosolids, Environment International (2011) .

Papers Submitted

  1. Keller, A., Raju, N., Webster, T.F., Stapleton, H.M., Flame Retardant Applications in Camping Tents and Potential Exposure, Environmental Science & Technology Letters (2013) .
  2. Dong, W., Macaulay, L.J., Kwok, D., Hinton, D., Ferguson, P.L., and Stapleton, H.M., THE PBDE METABOLITE 6-OH-BDE-47 AFFECTS MELANIN PIGMENTATION AND THRβ mRNA EXPRESSION IN THE RETINA OF ZEBRAFISH EMBRYOS, Endocrine Disruptors (2013) .
  3. Hoffman, K., Fang, M., Horman, B., Patisaul, H. Garantziotis, S., Birnbaum, L., Stapleton, H.M., Urinary Tetrabromobenzoic Acid (TBBA) as a Biomarker of Exposure to the Flame Retardant Mixture Firemaster 550®, Environmental Health Perspectives (2013) .
  4. Holzem, R., Stapleton, H.M. Gunsch, C.K., Determining the Ecological Impacts of Organic Contaminants in Biosolids Using a High-Throughput Colorimetric Denitrification Assay: A Case Study with Antimicrobial Agents, Environ Sci & Technol (2013) .
  5. Pillai, H., Fang, M., Beglov, D., Kozakov, D., Vajda, S., Stapleton, H.M., Webster, T.F., Schlesinger, J., The Flame Retardant Firemaster 550 Contains PPARγ Ligands That Induce 1 Adipogenesis 2 and Suppress Osteogenesis, Environmental Health Perspectives (2013) .
  6. H.M. Stapleton, S.D. Eagle, A. Sjodin, and T.F. Webster, Serum PBDEs in US Toddlers: Associations with Hand Wipes, House Dust and Socioeconomic Variables, Environmental Health Perspectives (2011) .
 
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