NICHOLAS SCHOOL FACULTY
division of Marine Science & Conservation
Publications [#155139] of Celia J Bonaventura
- C.J. Bonaventura, R. Henkens, A.I. Alayash and A.L. Crumbliss, Heme Access Determines the Propensities of Human and Clam Hbs for Nitrite-Induced Oxidation,
(last updated on 2009/01/15)
This is one of three papers I will publish in 2009 that show the importance of steric factors and conformational fluctuations in the control of hemoglobin function.
Clam Hbs provide useful information of how nitrite can regulate blood pressure. Oxygen was found to play a critical role in "clamming up" the active site of a nitrite-resistant clam Hb.
hemoglobin • oxidative damage • nitrosative damage