Papers Published

  1. Malkin, R.A., The matched-pairs defibrillation efficacy hypothesis test, 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21 Canadian Medical and Biological Engineering Conference (Cat. No.95CH35746), vol. vol.1 (1997), pp. 263 - 4, Montreal, Que., Canada [IEMBS.1995.575101]
    (last updated on 2007/04/14)

    Abstract:
    It is common to statistically test the hypothesis that one defibrillation technique is better than another. A standard approach is to estimate the DF50 (the shock strength which defibrillates 50% of the time) on a set of subjects under test and control conditions, analyzing the results by pairing the DF50's on an animal-by-animal basis. This paper presents a new approach based on pairing the data on a stimulus-by-stimulus basis. The new approach (matched-pairs) is shown to be easy to use, more versatile, and more sensitive (lower p-values) than the standard approach. The matched-pairs approach is particularly useful in clinical studies where many subjects may receive only a few stimuli

    Keywords:
    cardiology;defibrillators;patient treatment;statistical analysis;


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