Publications [#353093] of Peter A Ubel

We've launched a new site so please go to People & Research for current information on our faculty and staff.

Journal Articles

  1. Hildenbrand, JD; Davis, DM; El-Jawahri, A; Herring, KW; Locke, SC; Pollak, KI; Samsa, GP; Steinhauser, KE; Troy, JD; Ubel, PA; Leblanc, TW. "A novel decision aid for acute myeloid leukemia: a feasibility and preliminary efficacy trial.." Support Care Cancer 29.7 (July, 2021): 3563-3569. [doi]
    (last updated on 2024/04/22)

    Abstract:
    PURPOSE: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by a poor prognosis but also a paradoxical possibility of cure. This renders decision-making complex and imminent. Unfortunately, many patients with AML misestimate their prognosis and treatment risk. While decision aids can improve illness understanding and reduce decisional conflict, there are no validated decision aids for AML. We developed and tested a novel AML decision aid (NCT03442452). METHODS: Patients (n = 20) were recruited at Duke University from May 2018 to February 2019. Participants completed assessments of AML knowledge and decisional conflict, before and after using the electronic decision aid. The primary endpoint was feasibility (endpoint met if > 80% of study participants completed all study components). Secondary analyses of efficacy were conducted using paired t tests for dependent pre-/post-samples. RESULTS: The primary endpoint of feasibility was met (100% of participants completed all study components). Secondary analyses showed improved knowledge and reduced decisional conflict after using the decision aid. Knowledge scores improved from a mean of 11.8 (out of 18) correct items at baseline to 15.1 correct items after using the decision aid (mean difference 3.35; p < 0.0001). Decisional conflict scores reduced significantly from baseline to post-test as well (mean difference - 6.5; p = 0.02). CONCLUSION: These findings suggest that our AML decision aid is a useful tool to improve the patient experience and promote shared decision-making in AML. A randomized efficacy trial is planned.

Peter A Ubel