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Publications [#231459] of Gregory A. Wray

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Papers Published

  1. Muntané, G; Horvath, JE; Hof, PR; Ely, JJ; Hopkins, WD; Raghanti, MA; Lewandowski, AH; Wray, GA; Sherwood, CC, Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission., Cerebral Cortex (New York, N.Y. : 1991), vol. 25 no. 6 (June, 2015), pp. 1596-1607, ISSN 1047-3211 [doi]
    (last updated on 2019/11/18)

    Increased relative brain size characterizes the evolution of primates, suggesting that enhanced cognition plays an important part in the behavioral adaptations of this mammalian order. In addition to changes in brain anatomy, cognition can also be regulated by molecular changes that alter synaptic function, but little is known about modifications of synapses in primate brain evolution. The aim of the current study was to investigate the expression patterns and evolution of 20 synaptic genes from the prefrontal cortex of 12 primate species. The genes investigated included glutamate receptors, scaffolding proteins, synaptic vesicle components, as well as factors involved in synaptic vesicle release and structural components of the nervous system. Our analyses revealed that there have been significant changes during primate brain evolution in the components of the glutamatergic signaling pathway in terms of gene expression, protein expression, and promoter sequence changes. These results could entail functional modifications in the regulation of specific genes related to processes underlying learning and memory.

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