Amy K Schmid, Assistant Professor  

Systems biology of archaea; regulation of responses to environmental change.

Education:
PhD, University of Washington, 2004
BS, Marquette University, 1997

Email Address: amy.schmid@duke.edu
Web Page: http://www.biology.duke.edu/schmidlab

Specialties:
Genomics
Cell and Molecular Biology

Research Categories: Systems biology of archaea: understanding regulatory network responses to environmental extremes

Research Description: How organisms evolve adaptive solutions to stress is a fundamental question in biology. Our research goal is to understand the dynamic mechanisms by which organisms integrate signals and regulate responses to a changing environment for adaptation and survival. Our working hypothesis is that transcription factors and posttranscriptional effectors work in concert via a complex regulatory network to bring about the appropriate response and adaptation to changing conditions. To test this, we study archaeal extremophiles using systems biology approaches. These model organisms routinely encounter conditions at the limits of sustainable life and are thought to be some of the most ancient life forms on earth. As such, they present a unique opportunity to characterize the biological response to extreme environmental variance and how these adaptations evolved. In this relatively simple microbial system, we aim to develop transcriptional and posttranscriptional regulatory network models for the quantitative prediction of induced phenotypic changes at these extremes. Research toward these goals will lay the foundation for rational re-engineering of cellular physiology for desired outcomes such as targeted industrial, environmental and medical purposes.

Recent Publications   (More Publications)   (search)

  1. AK Schmid, DJ Reiss, M Pan, T Koide, NS Baliga, A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability., Molecular systems biology, England, vol. 5 (2009), pp. 282  [abs].
  2. T Koide, DJ Reiss, JC Bare, WL Pang, MT Facciotti, AK Schmid, M Pan, B Marzolf, PT Van, FY Lo, A Pratap, EW Deutsch, A Peterson, D Martin, NS Baliga, Prevalence of transcription promoters within archaeal operons and coding sequences., Molecular systems biology, England, vol. 5 (2009), pp. 285  [abs].
  3. PT Van, AK Schmid, NL King, A Kaur, M Pan, K Whitehead, T Koide, MT Facciotti, YA Goo, EW Deutsch, DJ Reiss, P Mallick, NS Baliga, Halobacterium salinarum NRC-1 PeptideAtlas: toward strategies for targeted proteomics and improved proteome coverage., Journal of proteome research, United States, vol. 7 no. 9 (September, 2008), pp. 3755-64  [abs].
  4. R Bonneau, MT Facciotti, DJ Reiss, AK Schmid, M Pan, A Kaur, V Thorsson, P Shannon, MH Johnson, JC Bare, W Longabaugh, M Vuthoori, K Whitehead, A Madar, L Suzuki, T Mori, DE Chang, J Diruggiero, CH Johnson, L Hood, NS Baliga, A predictive model for transcriptional control of physiology in a free living cell., Cell, United States, vol. 131 no. 7 (December, 2007), pp. 1354-65  [abs].
  5. AK Schmid, DJ Reiss, A Kaur, M Pan, N King, PT Van, L Hohmann, DB Martin, NS Baliga, The anatomy of microbial cell state transitions in response to oxygen., Genome research, United States, vol. 17 no. 10 (October, 2007), pp. 1399-413  [abs].

Curriculum Vitae

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