Nicolas Buchler, Assistant Professor
Our lab is interested in the systems biology and evolution of epigenetic switches (bistability) and clocks (oscillators) in gene regulatory networks, two functions that are essential for patterning, cell proliferation, and differentiation in biological systems. We also study biochemical oscillators such as the cell cycle, metabolic rhythms, and circadian clocks, which co-exist in the same cells and interact with one another through shared resources.
Ph.D., University of Michigan at Ann Arbor, 2001
M.S., University of Michigan at Ann Arbor, 1998
B.S., University of California at San Diego, 1995
Cell and Molecular Biology
Research Categories: Molecular mechanisms and the evolution of switches and oscillators in gene networks; systems biology; comparative genomics
- M Zhou, W Wang, S Karapetyan, M Mwimba, J Marqués, NE Buchler and X Dong, Redox rhythm reinforces the circadian clock to gate immune response., Nature, vol. 523 no. 7561 (July, 2015), pp. 472-476 [DukeSpace], [doi] [abs].
- Y Tanouchi, A Pai, H Park, S Huang, R Stamatov, NE Buchler and L You, A noisy linear map underlies oscillations in cell size and gene expression in bacteria., Nature, vol. 523 no. 7560 (July, 2015), pp. 357-360 [DukeSpace], [doi] [abs].
- A Mazo-Vargas, H Park, M Aydin and NE Buchler, Measuring fast gene dynamics in single cells with time-lapse luminescence microscopy., Molecular biology of the cell, vol. 25 no. 22 (November, 2014), pp. 3699-3708 [DukeSpace], [doi] [abs].
- FR Cross, NE Buchler and JM Skotheim, Evolution of networks and sequences in eukaryotic cell cycle control, Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 366 no. 1584 (December, 2011), pp. 3532-3544 [DukeSpace], [doi] [abs].
- NE Buchler and FR Cross, Protein sequestration generates a flexible ultrasensitive response in a genetic network, Molecular Systems Biology, vol. 5 (2009), pp. 272 [doi] [abs].
- NE Buchler and M Louis, Molecular Titration and Ultrasensitivity in Regulatory Networks, Journal of Molecular Biology, vol. 384 no. 5 (December, 2008), pp. 1106-1119 [doi] [abs].