Chandra L Tucker, Assistant Research Professor
Education:
PhD, University of Washington, 1999
BS, California Institute of Technology, 1990
Office Location: 371D BioSci
Office Phone: (919) 613-8172
Email Address: chandra@duke.edu
Web Page: http://www.biology.duke.edu/tuckerlab/
Specialties:
Cell and Molecular Biology
Genetics
Genomics
Research Categories: Protein technologies and chemical genomics in yeast
Research Description: My research focuses on the development of novel methodologies, assays, and approaches for characterizing proteins, using the model yeast Saccharomyces cerevisiae. As yeast is a simple, unicellular, genetic organism, it is uniquely suited to act as a "living test tube" for use in characterization of heterologous systems. Specifically, my interests include developing genetic assays in yeast to characterize disease proteins, engineering ligand-regulated proteins and protein switches, expanding current technologies for detecting and analyzing protein interactions, and developing approaches to characterize and rescue misfolded proteins.
Recent Publications (search)
- Tucker, C. L., Peteya, L, Pittman, A.M.C, and Zhong, J., A genetic test for yeast two-hybrid bait competency using RanBPM, Genetics, vol. 182 (2009), pp. 1377-1379 .
- Hopper, E. D., Pittman, A.M.C., Tucker, C. L., Campa, M. J., Patz, E. F., and Fitzgerald, M. F., Hydrogen/deuterium exchange- and protease digestion-based screening assay for protein-ligand binding detection., Anal. Chem., vol. 81 (2009), pp. 6860-6867 .
- Hopper, E. D., Pittman, A.M.C., Fitzgerald, M.C., and Tucker, C. L., In vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase, J. Biol. Chem., vol. 283 (2008), pp. 30493-30502 .
Duke Biology Box 90338 Durham, NC 27708 Phone: 919-660-7372 Fax: 919-660-7293