Publications [#38896] of David R. Sherwood
search .Papers Published
- DR Sherwood, JA Butler, JM Kramer, PW Sternberg, FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans.,
Cell, United States, vol. 121 no. 6
(June, 2005),
pp. 951-62 .
(last updated on 2005/07/07)Abstract:
Cell invasion through basement membranes is crucial during morphogenesis and cancer metastasis. Here, we genetically dissect this process during anchor-cell invasion into the vulval epithelium in C. elegans. We have identified the fos transcription factor ortholog fos-1 as a critical regulator of basement-membrane removal. In fos-1 mutants, the gonadal anchor cell extends cellular processes normally toward vulval cells, but these processes fail to remove the basement membranes separating the gonad from the vulval epithelium. fos-1 is expressed in the anchor cell and controls invasion cell autonomously. We have identified ZMP-1, a membrane-type matrix metalloproteinase, CDH-3, a Fat-like protocadherin, and hemicentin, a fibulin family extracellular matrix protein, as transcriptional targets of FOS-1 that promote invasion. These results reveal a key genetic network that controls basement-membrane removal during cell invasion.
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