Emily F. Ozdowski, Instructor B  

Emily F. Ozdowski

My interests are in genetic forms of neurodegenerative disease and how we can model these defects in less complex organisms, such as Drosophila melanogaster. We study Spastin, the microtubule-severing protein that, when lost, is responsible for over half the cases of Hereditary Spastic Paraplegia. I am working to uncover genetic interactions with spastin and potential methods of regulation.

Ph.D., University of Virginia, 2006
Postdoctoral Scholar, Duke University, 2011

Office Location: 130 Science Drive, Box 90338, Biosci 072A, Durham, NC 27708-0338
Office Phone: (919) 684-5446
Email Address: emily.ozdowski@duke.edu

Developmental Biology

Recent Publications   (search)

  1. Ozdowski, EF; Baxter, SL; Sherwood, NT, Drosophila Models of Hereditary Spastic Paraplegia, in Movement Disorders: Genetics and Models: Second Edition (October, 2014), pp. 1103-1122, Elsevier [doi]  [abs].
  2. Ozdowski, EF; Gayle, S; Bao, H; Zhang, B; Sherwood, NT, Loss of Drosophila melanogaster p21-activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations., Genetics, vol. 189 no. 1 (September, 2011), pp. 123-135 [doi]  [abs].
  3. Du, F; Ozdowski, EF; Kotowski, IK; Marchuk, DA; Sherwood, NT, Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia., Human Molecular Genetics, vol. 19 no. 10 (May, 2010), pp. 1883-1896 [20154342], [doi]  [abs].
  4. Ozdowski, EF; Mowery, YM; Cronmiller, C, Stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation., Genetics, vol. 183 no. 3 (November, 2009), pp. 1027-1040 [doi]  [abs].
  5. Willard, SS; * Ozdowski, EF; * Jones, NA; Cronmiller, C, stall-mediated extrinsic control of ovarian follicle formation in Drosophila, Genetics, vol. 168 no. 1 (September, 2004), pp. 191-198 (*These authors contributed equally to this work..) .