Ryan Baugh, Assistant Professor  

Ryan Baugh

We study nutritional control of development in the model system Caenorhabditis elegans. Life in the wild is characterized by feast or famine for this free-living nematode, and it has remarkable abilities to modify its development in response to environmental conditions. We are interested in the signaling pathways and gene regulatory mechanisms that enable the worm to reversibly arrest development and resist stress in response to starvation.

Education:
PhD, Harvard University, 2004
BS, University of Georgia, 1997

Office Location: FFSC: 4314
Office Phone: (919) 613-8179
Email Address: ryan.baugh@duke.edu
Web Page: http://www.biology.duke.edu/baughlab

Specialties:
Developmental Biology
Cell and Molecular Biology
Genomics
Genetics

Research Categories: Animal developmental genetics and genomics

Research Description:

Areas of Interest:
developmental arrest and recovery
neuroendocrine signaling
growth control
starvation

Representative Publications   (search)

  1. L. Ryan Baugh, John DeModena, and Paul W. Sternberg, RNA Pol II Accumulates at Promoters of Growth Genes During Developmental Arrest, Science, vol. Online (February 26, 2009) [1169628]  [abs].
  2. L. Ryan Baugh and Paul W. Sternberg, DAF-16/FOXO Regulates Transcription of cki-1/Cip/Kip and Repression of lin-4 during C. elegans L1 Arrest, Current Biology, vol. 16 no. 8 (April, 2006), pp. 780-785  [abs].
  3. Itai Yanai*, L. Ryan Baugh*, Jessica J. Smith, Casey Roehrig, Shai S. Shen-Orr, Julia M. Claggett, Andrew A. Hill, Donna K. Slonim, Eugene L. Brown and Craig P. Hunter, Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression, Molecular Systems Biolgy, vol. 4 no. 163 (February, 2008)  [abs].
  4. L. Ryan Baugh and Craig P. Hunter, MyoD, Modularity, and Myogenesis: conservation of regulators and redundancy in C. elegans, Genes and Development, vol. 20 (December, 2006), pp. 3342-3346 .
  5. L. Ryan Baugh, Joanne C. Wen, Andrew A. Hill, Donna K. Slonim, Eugene L. Brown and Craig P. Hunter, Synthetic Lethal Analysis of C. elegans Posterior Patterning Genes Identifies Conserved Genetic Interactions, Genome Biology, vol. 6 no. 5 (April, 2005), pp. R45  [abs].
  6. L. Ryan Baugh, Andrew A. Hill, Julia M. Clagget, Kate Hill-Harfe, Joanne C. Wen, Donna K. Slonim, Eugene L. Brown, and Craig P. Hunter, The Homeodomain Protein PAL-1 Specifies a Lineage-Specific Regulatory Network in the C. elegans Embryo, Development, vol. 132 no. 8 (April, 2005), pp. 1843-1854  [abs].
  7. L. Ryan Baugh, Andrew A. Hill, Donna K. Slonim, Eugene L. Brown, and Craig P. Hunter, Composition and Dynamics of the C. elegans Early Embryonic Transcriptome, Development, vol. 130 no. 5 (March, 2003), pp. 889-900  [abs].
  8. L. Ryan Baugh, A. A. Hill, E. L. Brown, and Craig P. Hunter, Quantitative Analysis of mRNA Amplification by in vitro Transcription, Nucleic Acids Research, vol. 29 no. 5 (March, 2001), pp. E29 .

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