Publications [#70270] of Meng Chen
search PubMed.Papers Published
- ZY Wang, T Nakano, J Gendron, J He, M Chen, D Vafeados, Y Yang, S Fujioka, S Yoshida, T Asami, J Chory, Nuclear-localized BZR1 mediates brassinosteroid-induced growth and feedback suppression of brassinosteroid biosynthesis.,
Dev Cell, United States, vol. 2 no. 4
(April, 2002),
pp. 505-13 (ISSN: 1534-5807.) .
(last updated on 2007/07/17)Abstract:
Plant steroid hormones, brassinosteroids (BRs), are perceived by a cell surface receptor kinase, BRI1, but how BR binding leads to regulation of gene expression in the nucleus is unknown. Here we describe the identification of BZR1 as a nuclear component of the BR signal transduction pathway. A dominant mutation bzr1-1D suppresses BR-deficient and BR-insensitive (bri1) phenotypes and enhances feedback inhibition of BR biosynthesis. BZR1 protein accumulates in the nucleus of elongating cells of dark-grown hypocotyls and is stabilized by BR signaling and the bzr1-1D mutation. Our results demonstrate that BZR1 is a positive regulator of the BR signaling pathway that mediates both downstream BR responses and feedback regulation of BR biosynthesis.
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