Publications [#228316] of Xinnian Dong

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Papers Published

  1. Wang, D; Pajerowska-Mukhtar, K; Culler, AH; Dong, X, Salicylic acid inhibits pathogen growth in plants through repression of the auxin signaling pathway., Current Biology : Cb, vol. 17 no. 20 (October, 2007), pp. 1784-1790 [17919906], [doi] .
    (last updated on 2022/07/03)

    The phytohormone auxin regulates almost every aspect of plant development. At the molecular level, auxin induces gene expression through direct physical interaction with the TIR1-like F box proteins, which in turn remove the Aux/IAA family of transcriptional repressors [1-4]. A growing body of evidence indicates that many plant pathogens can either produce auxin themselves or manipulate host auxin biosynthesis to interfere with the host's normal developmental processes [5-11]. In response, plants probably evolved mechanisms to repress auxin signaling during infection as a defense strategy. Plants overaccumulating the defense signal molecule salicylic acid (SA) frequently display morphological phenotypes that are reminiscent of auxin-deficient or auxin-insensitive mutants, indicating that SA might interfere with auxin responses. By using the Affymetrix ATH1 GeneChip for Arabidopsis thaliana, we performed a comprehensive study of the effects of SA on auxin signaling [12]. We found that SA causes global repression of auxin-related genes, including the TIR1 receptor gene, resulting in stabilization of the Aux/IAA repressor proteins and inhibition of auxin responses. We demonstrate that this inhibitory effect on auxin signaling is a part of the SA-mediated disease-resistance mechanism.