Publications [#228327] of Xinnian Dong

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Papers Published

  1. Cao, H; Li, X; Dong, X, Generation of broad-spectrum disease resistance by overexpression of an essential regulatory gene in systemic acquired resistance., Proceedings of the National Academy of Sciences of the United States of America, vol. 95 no. 11 (May, 1998), pp. 6531-6536 [9601001], [doi] .
    (last updated on 2022/07/01)

    The recently cloned NPR1 gene of Arabidopsis thaliana is a key regulator of acquired resistance responses. Upon induction, NPR1 expression is elevated and the NPR1 protein is activated, in turn inducing expression of a battery of downstream pathogenesis-related genes. In this study, we found that NPR1 confers resistance to the pathogens Pseudomonas syringae and Peronospora parasitica in a dosage-dependent fashion. Overexpression of NPR1 leads to enhanced resistance with no obvious detrimental effect on the plants. Thus, for the first time, a single gene is shown to be a workable target for genetic engineering of nonspecific resistance in plants.