L. Ryan Baugh, Associate Professor  

L. Ryan Baugh

We use the roundworm Caenorhabditis elegans as model to investigate how animals cope with fluctuations in food availability. We are interested in the signaling pathways and gene regulatory mechanisms that enable this worm to reversibly arrest development and endure starvation. We are interested in adaptation to nutrient stress over different time scalse, including nongenetic inheritance and multigenerational phenotypic plasticity.

Ph.D.,  Harvard University, 2004
B.S., University of Georgia, Athens, 1997

Office Location: 4314 French Family Science Center, Duke Box 90338, Durham, NC 27708
Office Phone: (919) 613-8179
Email Address: ryan.baugh@duke.edu
Web Page: http://www.biology.duke.edu/baughlab
Additional Web Page: https://baughlab.biology.duke.edu/

Developmental Biology
Cell and Molecular Biology

Research Categories: Developmental genetics and genomics

Research Description: We study nutritional control of development in the roundworm Caenorhabditis elegans. We are interested in the signaling pathways and gene regulatory mechanisms that enable the worm to reversibly arrest development and resist stress in response to starvation. We are also investigating epigenetic mechanisms responsible for transgenerational effects of starvation.

Areas of Interest:
nutritional control of development
gene regulation
insulin signaling

Representative Publications   (More Publications)   (search)

  1. Y Chen, LR Baugh, Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest., Developmental Biology (August, 2014) [002], [doi]  [abs].
  2. Schindler, AJ; Baugh, LR; Sherwood, DR, Identification of late larval stage developmental checkpoints in Caenorhabditis elegans regulated by insulin/IGF and steroid hormone signaling pathways., Plos Genetics, vol. 10 no. 6 (June, 2014), pp. e1004426 [repository], [doi]  [abs].
  3. Maxwell, CS; Kruesi, WS; Core, LJ; Kurhanewicz, N; Waters, CT; Lewarch, CL; Antoshechkin, I; Lis, JT; Meyer, BJ; Baugh, LR, Pol II docking and pausing at growth and stress genes in C. elegans., Cell Reports, vol. 6 no. 3 (February, 2014), pp. 455-466 [repository], [doi]  [abs].
  4. Baugh, LR, To grow or not to grow: nutritional control of development during Caenorhabditis elegans L1 arrest., Genetics, vol. 194 no. 3 (July, 2013), pp. 539-555 [23824969], [doi]  [abs] [author's comments].
  5. Moore, BT; Jordan, JM; Baugh, LR, WormSizer: high-throughput analysis of nematode size and shape., Plos One, vol. 8 no. 2 (January, 2013), pp. e57142 [23451165], [doi]  [abs].
  6. Maxwell, CS; Antoshechkin, I; Kurhanewicz, N; Belsky, JA; Baugh, LR, Nutritional control of mRNA isoform expression during developmental arrest and recovery in C. elegans., Genome Research, vol. 22 no. 10 (October, 2012), pp. 1920-1929 [22539650], [doi]  [abs].
  7. Zaslaver, A; Baugh, LR; Sternberg, PW, Metazoan operons accelerate recovery from growth-arrested states., Cell, vol. 145 no. 6 (June, 2011), pp. 981-992 [repository], [doi]  [abs].
  8. Baugh, LR; Kurhanewicz, N; Sternberg, PW, Sensitive and precise quantification of insulin-like mRNA expression in Caenorhabditis elegans., Plos One, vol. 6 no. 3 (March, 2011), pp. e18086 [21445366], [doi]  [abs].
  9. Baugh, LR; Demodena, J; Sternberg, PW, RNA Pol II accumulates at promoters of growth genes during developmental arrest., Science (New York, N.Y.), vol. 324 no. 5923 (April, 2009), pp. 92-94 [1169628], [doi]  [abs].
  10. Baugh, LR; Sternberg, PW, DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest., Current Biology : Cb, vol. 16 no. 8 (April, 2006), pp. 780-785 [doi]  [abs].