Publications [#262543] of Tuan Vo-Dinh

Papers Published

1. Wang, H-N; Dhawan, A; Du, Y; Batchelor, D; Leonard, DN; Misra, V; Vo-Dinh, T, Molecular sentinel-on-chip for SERS-based biosensing., Physical chemistry chemical physics : PCCP, vol. 15 no. 16 (April, 2013), pp. 6008-6015 [23493773], [doi]
   (last updated on 2024/04/16)

   Abstract:
   The development of DNA detection techniques on large-area plasmonics-active platforms is critical for many medical applications such as high-throughput screening, medical diagnosis and systems biology research. Here, we report for the first time a unique "molecular sentinel-on-chip" (MSC) technology for surface-enhanced Raman scattering (SERS)-based DNA detection. This unique approach allows label-free detection of DNA molecules on chips developed on a wafer scale using large area nanofabrication methodologies. To develop plasmonics-active biosensing platforms in a repeatable and reproducible manner, we employed a combination of deep UV lithography, atomic layer deposition, and metal deposition to fabricate triangular-shaped nanowire (TSNW) arrays having controlled sub-10 nm gap nanostructures over an entire 6 inch wafer. The detection of a DNA sequence of the Ki-67 gene, a critical breast cancer biomarker, on the TSNW substrate illustrates the usefulness and potential of the MSC technology as a novel SERS-based DNA detection method.