Publications [#262655] of Tuan Vo-Dinh

Papers Published

1. Scaffidi, JP; Gregas, MK; Lauly, B; Zhang, Y; Vo-Dinh, T, Activity of psoralen-functionalized nanoscintillators against cancer cells upon X-ray excitation., ACS nano, vol. 5 no. 6 (June, 2011), pp. 4679-4687 [21553850], [doi]
   (last updated on 2024/04/24)

   Abstract:
   We report development of a nanoparticle-based, X-ray-activated anticancer "nanodrug" composed of yttrium oxide (Y(2)O(3)) nanoscintillators, a fragment of the HIV-1 TAT peptide, and psoralen. In this formulation, X-ray radiation is absorbed by the Y(2)O(3) nanoscintillators, which then emit UVA light. Absorption of UVA photons by nanoparticle-tethered psoralen has the potential to cross-link adenine and thymine residues in DNA. UVA-induced cross-linking by free psoralen upon activation with UVA light has previously been shown to cause apoptosis in vitro and an immunogenic response in vivo. Studies using the PC-3 human prostate cancer cell line demonstrate that X-ray excitation of these psoralen-functionalized Y(2)O(3) nanoscintillators yields concentration-dependent reductions in cell number when compared to control cultures containing psoralen-free Y(2)O(3) nanoscintillators.