Publications [#262901] of Tuan Vo-Dinh

Papers Published

1. Moreno-Bondi, MC; Alarie, JP; Vo-Dinh, T, Multi-analyte analysis system using an antibody-based biochip., Analytical and bioanalytical chemistry, vol. 375 no. 1 (January, 2003), pp. 120-124, ISSN 1618-2642 [12520447], [doi]
   (last updated on 2024/04/24)

   Abstract:
   A multi-analyte detection system using a unique antibody (Ab) biochip is described. The Ab-based biochip, also referred to as the protein biochip, uses a sensor array based on a complementary metal oxide silicon (CMOS) integrated circuit. The Ab-biochip has a sampling platform of four-by-four microarrays of antibodies deposited onto a Nylon membrane substrate. The micro-arrayed antibodies can be interrogated simultaneously or sequentially using the biochip sensing array detector with the use of a diffractive optical element illuminating each antibody spot individually. The usefulness of the Ab biochip is illustrated by the measurements of immunoglobulin G (IgG) used as the model analyte system. The detection limit for Cy5-labeled IgG molecules was 13 pg.

   Keywords:
   Antibodies;Biotechnology;Proteins;CMOS integrated circuits;Sampling;Sensors;Immunology;Bioassay;