| Publications [#335894] of Tuan Vo-Dinh
Papers Published
- Vo-Dinh, T; Inman, B; Maccarini, P; Palmer, G; Liu, Y, Synergistic immuno photothermal nanotherapy (SYMPHONY) to treat metastatic cancers and induce anti-cancer vaccine effect,
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10484
(January, 2018), SPIE, ISBN 9781510614536 [doi]
(last updated on 2024/04/17)
Abstract: Biocompatible gold nanostars (GNS) with tip-enhanced electromagnetic and optical properties have been developed and applied for multifunctional cancer diagnostics and therapy (theranostics). Their multiple sharp branches acting like "lightning rods" can convert safely and efficiently light into heat. As with other nanoparticles, GNS sizes can be controlled so that they passively accumulate in tumors due to the enhanced permeability and retention (EPR) effect of tumor vasculature. This feature improves tumor-targeting precision and permits the use of reduced laser energy required to destroy the targeted cancer cells. The ability to selectively heat tumor areas where GNS are located while keeping surrounding healthy tissues at significantly lower temperatures offers significant advantages over other thermal therapies. GNS-mediated photothermal therapy combined with checkpoint immunotherapy was shown to reverse tumor-mediated immunosuppression, leading to the treatment of not only primary tumors but also cancer metastasis as well as inducing effective long-lasting immunity, i.e. an anticancer 'vaccine' effect.
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