Publications [#232407] of Alvin L. Crumbliss

Journal Articles

  1. Gebhardt, P; Crumbliss, AL; Miller, MJ; Möllmann, U, "Synthesis and biological activity of saccharide based lipophilic siderophore mimetics as potential growth promoters for mycobacteria.", Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and MedicineFebruary,, 2008, 21(1), 41-51 (OnLine First: 10.1007/s10534-007-9091-x.) [17390213], [doi].
    (last updated on 2023/06/01)

    Abstract:
    Siderophores based on sugar backbones substituted at the 2,3,4- or 2,3,6 positions with hydroxamic or retro-hydroxamic acid chelating units were synthesized and characterized. The alkyl terminus of the iron-coordinating side chain units facilitate lipophilic interactions. Iron coordination properties and complex stability were investigated by ESI-MS and the CAS-Test. The results were correlated to structure activity relationships determined by microbial growth promotion studies under iron limited conditions using wild type strains and iron transport mutants of Mycobacterium smegmatis.