Barbara R. Shaw

Barbara R. Shaw

Office: 2105 French Family Science Ctr, Box 90346, Chemistry Department, Durham, NC 2770
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Research Interests

Our laboratory studies the chemical reactivity of DNA and synthesizes modified nucleic acids as potential antitumor and antisense agents. We use biophysical, biochemical, and genetic techniques together with synthetic chemistry to understand pathways of mutation in DNA and to design novel nucleic acid analogues that might find use in the control of gene expression and signal transduction, in the treatment of tumors and cancer, and in antisense and gene therapy.


Most recent publications in PubMed