Publications [#233885] of Barbara R. Shaw
Journal Articles
- Lin, J; Shaw, BR, "Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate.", Nucleosides, nucleotides & nucleic acidsApril,, 2001, 20(4-7), 1325-1328 [11563014], [doi].
(last updated on 2024/04/18)Abstract:
A new type of non-ionic nucleotide analogue with a doubly modified internucleotide linkage, P-boranomethylphosphonate, has been successfully synthesized and characterized. Dithymidine boranomethylphosphonate 5 is the first example of a P-boranomethylphosphonate compound; it is a highly lipophilic phosphodiester analog, which is almost totally resistant to both snake venom phosphodiesterase (SVPDE) and bovine spleen phosphodiesterase (BSPDE). P-boranomethylphosphonates are expected to be promising candidates for mechanistic, diagnostic and therapeutic applications.