Publications of Emily R. Derbyshire

Journal Articles

  1. Lee, H; Sylvester, K; Derbyshire, ER; Hong, J, "Synthesis and Analysis of Natural-Product-Like Macrocycles by Tandem Oxidation/Oxa-Conjugate Addition Reactions.", Chemistry (Weinheim an Der Bergstrasse, Germany)May,, 2019, 25(26), 6500-6504 [doi[abs].

  2. Raphemot, R; Eubanks, AL; Toro-Moreno, M; Geiger, RA; Hughes, PF; Lu, K-Y; Haystead, TAJ; Derbyshire, ER, "Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites.", Cell Chemical BiologyMarch,, 2019, 26(3), 411-419.e7 [doi[abs].

  3. Eubanks, AL; Perkins, MM; Sylvester, K; Ganley, JG; Posfai, D; Sanschargrin, PC; Hong, J; Sliz, P; Derbyshire, ER, "In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors.", ChemmedchemDecember,, 2018, 13(23), 2479-2483 [doi[abs].

  4. Ganley, JG; Carr, G; Ioerger, TR; Sacchettini, JC; Clardy, J; Derbyshire, ER, "Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes.", Chembiochem : a European Journal of Chemical BiologyAugust,, 2018, 19(15), 1590-1594 [doi[abs].

  5. Posfai, D; Sylvester, K; Reddy, A; Ganley, JG; Wirth, J; Cullen, QE; Dave, T; Kato, N; Dave, SS; Derbyshire, ER, "Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection.", Plos PathogensMay,, 2018, 14(5), e1007057 [doi[abs].

  6. Posfai, D; Sylvester, K; Reddy, A; Ganley, JG; Wirth, J; Cullen, QE; Dave, T; Kato, N; Dave, SS; Derbyshire, ER, "Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection", Plos PathogensMay,, 2018, 14(5), 26 pages, PUBLIC LIBRARY SCIENCE [doi].

  7. Posfai, D; Eubanks, AL; Keim, AI; Lu, K-Y; Wang, GZ; Hughes, PF; Kato, N; Haystead, TA; Derbyshire, ER, "Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity.", Antimicrobial Agents and ChemotherapyApril,, 2018, 62(4) [doi[abs].

  8. Ganley, JG; Toro-Moreno, M; Derbyshire, ER, "Exploring the Untapped Biosynthetic Potential of Apicomplexan Parasites.", BiochemistryJanuary,, 2018, 57(4), 365-375 [doi[abs].

  9. Totzke, J; Gurbani, D; Raphemot, R; Hughes, PF; Bodoor, K; Carlson, DA; Loiselle, DR; Bera, AK; Eibschutz, LS; Perkins, MM; Eubanks, AL; Campbell, PL; Fox, DA; Westover, KD; Haystead, TAJ; Derbyshire, ER, "Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease.", Cell Chemical BiologyAugust,, 2017, 24(8), 1029-1039.e7 [doi[abs].

  10. Kato, N; Comer, E; Sakata-Kato, T; Sharma, A; Sharma, M; Maetani, M; Bastien, J; Brancucci, NM; Bittker, JA; Corey, V; Clarke, D; Derbyshire, ER; Dornan, GL; Duffy, S; Eckley, S; Itoe, MA; Koolen, KMJ; Lewis, TA; Lui, PS; Lukens, AK; Lund, E; March, S; Meibalan, E; Meier, BC; McPhail, JA; Mitasev, B; Moss, EL; Sayes, M; Van Gessel, Y; Wawer, MJ; Yoshinaga, T; Zeeman, A-M; Avery, VM; Bhatia, SN; Burke, JE; Catteruccia, F; Clardy, JC; Clemons, PA; Dechering, KJ; Duvall, JR; Foley, MA; Gusovsky, F; Kocken, CHM; Marti, M; Morningstar, ML; Munoz, B; Neafsey, DE; Sharma, A; Winzeler, EA; Wirth, DF; Scherer, CA; Schreiber, SL, "Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.", NatureOctober,, 2016, 538(7625), 344-349 [doi[abs].

  11. Raphemot, R; Posfai, D; Derbyshire, ER, "Current therapies and future possibilities for drug development against liver-stage malaria.", The Journal of Clinical InvestigationJune,, 2016, 126(6), 2013-2020 [doi[abs].

  12. Raphemot, R; Lafuente-Monasterio, MJ; Gamo-Benito, FJ; Clardy, J; Derbyshire, ER, "Discovery of Dual-Stage Malaria Inhibitors with New Targets.", Antimicrobial Agents and ChemotherapyDecember,, 2015, 60(3), 1430-1437 [doi[abs].

  13. Herman, JD; Pepper, LR; Cortese, JF; Estiu, G; Galinsky, K; Zuzarte-Luis, V; Derbyshire, ER; Ribacke, U; Lukens, AK; Santos, SA; Patel, V; Clish, CB; Sullivan, WJ; Zhou, H; Bopp, SE; Schimmel, P; Lindquist, S; Clardy, J; Mota, MM; Keller, TL; Whitman, M; Wiest, O; Wirth, DF; Mazitschek, R, "The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.", Science Translational MedicineMay,, 2015, 7(288), 288ra77 [doi[abs].

  14. Derbyshire, ER; Zuzarte-Luís, V; Magalhães, AD; Kato, N; Sanschagrin, PC; Wang, J; Zhou, W; Miduturu, CV; Mazitschek, R; Sliz, P; Mota, MM; Gray, NS; Clardy, J, "Chemical interrogation of the malaria kinome.", Chembiochem : a European Journal of Chemical BiologySeptember,, 2014, 15(13), 1920-1930 [doi[abs].

  15. Derbyshire, ER; Min, J; Guiguemde, WA; Clark, JA; Connelly, MC; Magalhães, AD; Guy, RK; Clardy, J, "Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites.", Antimicrobial Agents and ChemotherapyJanuary,, 2014, 58(3), 1516-1522 [24366746], [doi[abs].

  16. Derbyshire, ER; Clardy, J, "Closing in on a new treatment for sleeping sickness.", ElifeJanuary,, 2013, 2, e01042 [23853715], [doi[abs].

  17. Fernhoff, NB; Derbyshire, ER; Underbakke, ES; Marletta, MA, "Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide.", The Journal of Biological ChemistryDecember,, 2012, 287(51), 43053-43062 [23093402], [doi[abs].

  18. Gunn, A; Derbyshire, ER; Marletta, MA; Britt, RD, "Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR).", BiochemistryOctober,, 2012, 51(42), 8384-8390 [22985445], [doi[abs].

  19. Carr, G; Derbyshire, ER; Caldera, E; Currie, CR; Clardy, J, "Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.", Journal of Natural ProductsOctober,, 2012, 75(10), 1806-1809 [23025282], [doi[abs].

  20. Derbyshire, ER; Prudêncio, M; Mota, MM; Clardy, J, "Liver-stage malaria parasites vulnerable to diverse chemical scaffolds.", Proc Natl Acad Sci U S AMay,, 2012, 109(22), 8511-8516 [22586124], [doi[abs].

  21. Derbyshire, ER; Mazitschek, R; Clardy, J, "Characterization of Plasmodium liver stage inhibition by halofuginone.", ChemmedchemMay,, 2012, 7(5), 844-849 [22438279], [doi[abs].

  22. Derbyshire, ER; Marletta, MA, "Structure and regulation of soluble guanylate cyclase.", Annual Review of BiochemistryJanuary,, 2012, 81, 533-559 [22404633], [doi[abs].

  23. Dong, CK; Urgaonkar, S; Cortese, JF; Gamo, F-J; Garcia-Bustos, JF; Lafuente, MJ; Patel, V; Ross, L; Coleman, BI; Derbyshire, ER; Clish, CB; Serrano, AE; Cromwell, M; Barker, RH; Dvorin, JD; Duraisingh, MT; Wirth, DF; Clardy, J; Mazitschek, R, "Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.", Chemistry & BiologyDecember,, 2011, 18(12), 1602-1610 [22195562], [doi[abs].

  24. Derbyshire, ER; Mota, MM; Clardy, J, "The next opportunity in anti-malaria drug discovery: the liver stage.", Plos PathogensSeptember,, 2011, 7(9), e1002178 [21966266], [doi].

  25. Derbyshire, ER; Winter, MB; Ibrahim, M; Deng, S; Spiro, TG; Marletta, MA, "Probing domain interactions in soluble guanylate cyclase.", BiochemistryMay,, 2011, 50(20), 4281-4290 [21491957], [doi[abs].

  26. Ibrahim, M; Derbyshire, ER; Soldatova, AV; Marletta, MA; Spiro, TG, "Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence.", BiochemistryJune,, 2010, 49(23), 4864-4871 [20459051], [doi[abs].

  27. Derbyshire, ER; Deng, S; Marletta, MA, "Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding.", The Journal of Biological ChemistryJune,, 2010, 285(23), 17471-17478 [20231286], [doi[abs].

  28. Ibrahim, M; Derbyshire, ER; Marletta, MA; Spiro, TG, "Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy.", BiochemistryMay,, 2010, 49(18), 3815-3823 [20353168], [doi[abs].

  29. Fernhoff, NB; Derbyshire, ER; Marletta, MA, "A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase.", Proc Natl Acad Sci U S ADecember,, 2009, 106(51), 21602-21607 [20007374], [doi[abs].

  30. Derbyshire, ER; Fernhoff, NB; Deng, S; Marletta, MA, "Nucleotide regulation of soluble guanylate cyclase substrate specificity.", BiochemistryAugust,, 2009, 48(31), 7519-7524 [19527054], [doi[abs].

  31. Ibrahim, M; Derbyshire, ER; Marletta, MA; Spiro, TG, "Interaction of allosteric effectors with soluble guanylate cyclase heme domains: Role of heme distortion and propionate hydrogen bonding on synergistic activation", Abstracts of Papers of the American Chemical SocietyMarch,, 2009, 237 [Gateway.cgi].

  32. Derbyshire, ER; Marletta, MA, "Biochemistry of soluble guanylate cyclase.", Handbook of Experimental Pharmacology, 2009(191), 17-31 [19089323], [doi[abs].

  33. Winger, JA; Derbyshire, ER; Lamers, MH; Marletta, MA; Kuriyan, J, "The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase.", Bmc Structural BiologyOctober,, 2008, 8, 42 [18842118], [doi[abs].

  34. Derbyshire, ER; Gunn, A; Ibrahim, M; Spiro, TG; Britt, RD; Marletta, MA, "Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes.", BiochemistryMarch,, 2008, 47(12), 3892-3899 [18302323], [doi[abs].

  35. Derbyshire, ER; Marletta, MA, "Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide.", The Journal of Biological ChemistryDecember,, 2007, 282(49), 35741-35748 [17916555], [doi[abs].

  36. Martin, NI; Derbyshire, ER; Marletta, MA, "Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.", Bioorganic & Medicinal Chemistry LettersSeptember,, 2007, 17(17), 4938-4941 [17587571], [doi[abs].

  37. Winger, JA; Derbyshire, ER; Marletta, MA, "Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs.", The Journal of Biological ChemistryJanuary,, 2007, 282(2), 897-907 [17098738], [doi[abs].

  38. Cary, SPL; Winger, JA; Derbyshire, ER; Marletta, MA, "Nitric oxide signaling: no longer simply on or off.", Trends in Biochemical SciencesApril,, 2006, 31(4), 231-239 [16530415], [doi[abs].

  39. Derbyshire, ER; Tran, R; Mathies, RA; Marletta, MA, "Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase.", BiochemistryDecember,, 2005, 44(49), 16257-16265 [16331986], [doi[abs].