Publications of Michael C. Fitzgerald

Papers Submitted

  1. Tran, D.T., Adhikari J., and Fitzgerald, M.C., "Proteome-Wide Assay for Thermodynamic Analysis of Protein-Ligand Binding Interactions", Molecular and Cellular Proteomics, 2013.

Journal Articles

  1. Cabrera, A; Randall, TA; Ogburn, RN; Mebrahtu, B; Johnson, JHR; Foo, ACY; Fitzgerald, MC; Mueller, GA, "Are allergens more abundant and/or more stable than other proteins in pollens and dust?", AllergyMay,, 2020, 75(5), 1267-1269 [doi].

  2. Lu, K-Y; Quan, B; Sylvester, K; Srivastava, T; Fitzgerald, MC; Derbyshire, ER, "Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy.", Proceedings of the National Academy of Sciences of the United States of AmericaMarch,, 2020, 117(11), 5810-5817 [doi[abs].

  3. Cabrera, A; Wiebelhaus, N; Quan, B; Ma, R; Meng, H; Fitzgerald, MC, "Comparative Analysis of Mass-Spectrometry-Based Proteomic Methods for Protein Target Discovery Using a One-Pot Approach.", Journal of the American Society for Mass SpectrometryFebruary,, 2020, 31(2), 217-226 [doi[abs].

  4. Ma, R; Meng, H; Wiebelhaus, N; Fitzgerald, MC, "Chemo-Selection Strategy for Limited Proteolysis Experiments on the Proteomic Scale.", Analytical ChemistryDecember,, 2018, 90(23), 14039-14047 [doi[abs].

  5. Kaur, U; Meng, H; Lui, F; Ma, R; Ogburn, RN; Johnson, JHR; Fitzgerald, MC; Jones, LM, "Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale.", Journal of Proteome ResearchNovember,, 2018, 17(11), 3614-3627 [doi[abs].

  6. Meng, H; Ma, R; Fitzgerald, MC, "Chemical Denaturation and Protein Precipitation Approach for Discovery and Quantitation of Protein-Drug Interactions.", Analytical ChemistryAugust,, 2018, 90(15), 9249-9255 [doi[abs].

  7. Meng, H; Fitzgerald, MC, "Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer.", Journal of Proteome ResearchMarch,, 2018, 17(3), 1129-1137 [doi[abs].

  8. Ogburn, RN; Jin, L; Meng, H; Fitzgerald, MC, "Discovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets in MCF-7 Cells Using Large-Scale Protein Folding and Stability Measurements.", Journal of Proteome ResearchNovember,, 2017, 16(11), 4073-4085 [doi[abs].

  9. Liu, F; Meng, H; Fitzgerald, MC, "Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using SILAC-SPROX.", Journal of Proteome ResearchSeptember,, 2017, 16(9), 3277-3286 [doi[abs].

  10. Lim, KH; Dasari, AKR; Ma, R; Hung, I; Gan, Z; Kelly, JW; Fitzgerald, MC, "Pathogenic Mutations Induce Partial Structural Changes in the Native β-Sheet Structure of Transthyretin and Accelerate Aggregation.", BiochemistrySeptember,, 2017, 56(36), 4808-4818 [doi[abs].

  11. Randall, TA; London, RE; Fitzgerald, MC; Mueller, GA, "Proteases of Dermatophagoides pteronyssinus.", International Journal of Molecular SciencesJune,, 2017, 18(6) [doi[abs].

  12. Ogburn, RN; Randall, TA; Xu, Y; Roberts, JH; Mebrahtu, B; Karnuta, JM; Rider, SD; Kissling, GE; London, RE; Pomés, A; Arlian, L; Fitzgerald, MC; Mueller, GA, "Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?", The Journal of Allergy and Clinical ImmunologyMarch,, 2017, 139(3), 1030-1032.e1 [doi].

  13. Roberts, JH; Liu, F; Karnuta, JM; Fitzgerald, MC, "Discovery of Age-Related Protein Folding Stability Differences in the Mouse Brain Proteome.", Journal of Proteome ResearchDecember,, 2016, 15(12), 4731-4741 [doi[abs].

  14. Liu, F; Fitzgerald, MC, "Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis.", Journal of Proteome ResearchDecember,, 2016, 15(12), 4666-4674 [doi[abs].

  15. Jin, L; Wang, D; Gooden, DM; Ball, CH; Fitzgerald, MC, "Targeted Mass Spectrometry-Based Approach for Protein-Ligand Binding Analyses in Complex Biological Mixtures Using a Phenacyl Bromide Modification Strategy.", Analytical ChemistryNovember,, 2016, 88(22), 10987-10993 [doi[abs].

  16. Xu, Y; Wallace, MAG; Fitzgerald, MC, "Thermodynamic Analysis of the Geldanamycin-Hsp90 Interaction in a Whole Cell Lysate Using a Mass Spectrometry-Based Proteomics Approach.", Journal of the American Society for Mass SpectrometryOctober,, 2016, 27(10), 1670-1676 [doi[abs].

  17. Geer Wallace, MA; Kwon, D-Y; Weitzel, DH; Lee, C-T; Stephenson, TN; Chi, J-T; Mook, RA; Dewhirst, MW; Hong, J; Fitzgerald, MC, "Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements.", J Proteome ResAugust,, 2016, 15(8), 2688-2696 [doi[abs].

  18. Geer, MA; Fitzgerald, MC, "Characterization of the Saccharomyces cerevisiae ATP-Interactome using the iTRAQ-SPROX Technique.", Journal of the American Society for Mass SpectrometryFebruary,, 2016, 27(2), 233-243 [doi[abs].

  19. Kwon, D-Y; Lee, HE; Weitzel, DH; Park, K; Lee, SH; Lee, C-T; Stephenson, TN; Park, H; Fitzgerald, MC; Chi, J-T; Mook, RA; Dewhirst, MW; Lee, YM; Hong, J, "Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition.", Journal of Medicinal ChemistryOctober,, 2015, 58(19), 7659-7671 [doi[abs].

  20. Adhikari, J; West, GM; Fitzgerald, MC, "Global analysis of protein folding thermodynamics for disease state characterization.", Journal of Proteome ResearchMay,, 2015, 14(5), 2287-2297 [doi[abs].

  21. Adhikari, J; Fitzgerald, MC, "SILAC-pulse proteolysis: A mass spectrometry-based method for discovery and cross-validation in proteome-wide studies of ligand binding.", Journal of the American Society for Mass SpectrometryDecember,, 2014, 25(12), 2073-2083 [doi[abs].

  22. Xu, Y; Strickland, EC; Fitzgerald, MC, "Thermodynamic analysis of protein folding and stability using a tryptophan modification protocol.", Analytical ChemistryJuly,, 2014, 86(14), 7041-7048 [doi[abs].

  23. Tran, DT; Adhikari, J; Fitzgerald, MC, "StableIsotope Labeling with Amino Acids in Cell Culture (SILAC)-based strategy for proteome-wide thermodynamic analysis of protein-ligand binding interactions.", Molecular and Cellular ProteomicsJuly,, 2014, 13(7), 1800-1813 [doi[abs].

  24. Geer, MA; Fitzgerald, MC, "Energetics-based methods for protein folding and stability measurements.", Annual Review of Analytical Chemistry (Palo Alto, Calif.)January,, 2014, 7(7), 209-228 [doi[abs].

  25. Strickland, EC; Geer, MA; Hong, J; Fitzgerald, MC, "False-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform.", Journal of the American Society for Mass SpectrometryJanuary,, 2014, 25(1), 132-140 [24114261], [doi[abs].

  26. Strickland, EC; Geer, MA; Tran, DT; Adhikari, J; West, GM; DeArmond, PD; Xu, Y; Fitzgerald, MC, "Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation.", Nature ProtocolsJanuary,, 2013, 8(1), 148-161 [23257983], [doi[abs].

  27. Strickland, E.C., Geer, M.A., Hong, J., and Fitzgerald, M.C., "False-Positive Rate Determination of Protein Target Discovery using a Covalent Modification- and Mass", Journal of the American Society for Mass Spectrometry, 2013 [doi].

  28. Banerjee, S; Siburt, CJP; Mistry, S; Noto, JM; DeArmond, P; Fitzgerald, MC; Lambert, LA; Cornelissen, CN; Crumbliss, AL, "Evidence of Fe3+ interaction with the plug domain of the outer membrane transferrin receptor protein of Neisseria gonorrhoeae: implications for Fe transport.", Metallomics : Integrated Biometal ScienceApril,, 2012, 4(4), 361-372 [22399131], [doi[abs].

  29. Reichmann, D; Xu, Y; Cremers, CM; Ilbert, M; Mittelman, R; Fitzgerald, MC; Jakob, U, "Order out of disorder: working cycle of an intrinsically unfolded chaperone.", CellMarch,, 2012, 148(5), 947-957 [doi[abs].

  30. Tran, DT; Banerjee, S; Alayash, AI; Crumbliss, AL; Fitzgerald, MC, "Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry.", Analytical ChemistryFebruary,, 2012, 84(3), 1653-1660 [22185579], [doi[abs].

  31. Dearmond, PD; Xu, Y; Strickland, EC; Daniels, KG; Fitzgerald, MC, "Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach.", Journal of Proteome ResearchNovember,, 2011, 10(11), 4948-4958 [21905665], [doi[abs].

  32. Xu, Y; Falk, IN; Hallen, MA; Fitzgerald, MC, "Mass spectrometry- and lysine amidination-based protocol for thermodynamic analysis of protein folding and ligand binding interactions.", Analytical ChemistryMay,, 2011, 83(9), 3555-3562 [21456597], [doi[abs].

  33. DeArmond, PD; West, GM; Huang, H-T; Fitzgerald, MC, "Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures.", Journal of the American Society for Mass SpectrometryMarch,, 2011, 22(3), 418-430 [21472561], [doi[abs].

  34. Xu, Y; Falk, IN; Hallen, MA; Fitzgerald, MC, "Xu, Y., Falk, I.N., Hallen, M.A., and Fitzgerald, M.C.", Analytical Chemistry, 2011(83), 3555-3562.

  35. Dearmond, PD; West, GM; Anbalagan, V; Campa, MJ; Patz, EF; Fitzgerald, MC, "Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy.", J Biomol ScreenOctober,, 2010, 15(9), 1051-1062 [20855564], [doi[abs].

  36. Kim, H; Baker, JB; Park, Y; Park, H-B; DeArmond, PD; Kim, SH; Fitzgerald, MC; Lee, D-S; Hong, J, "Total synthesis, assignment of the absolute stereochemistry, and structure-activity relationship studies of subglutinols A and B.", Chemistry, an Asian JournalAugust,, 2010, 5(8), 1902-1910 [20564278], [doi[abs].

  37. West, GM; Thompson, JW; Soderblom, EJ; Dubois, LG; Dearmond, PD; Moseley, MA; Fitzgerald, MC, "Mass spectrometry-based thermal shift assay for protein-ligand binding analysis.", Anal ChemJuly,, 2010, 82(13), 5573-5581 [20527820], [doi[abs].

  38. West, GM; Tucker, CL; Xu, T; Park, SK; Han, X; Yates, JR; Fitzgerald, MC, "Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements.", Proceedings of the National Academy of Sciences of the United States of AmericaMay,, 2010, 107(20), 9078-9082 [20439767], [doi[abs].

  39. Xu, Y; Schmitt, S; Tang, L; Jakob, U; Fitzgerald, MC, "Thermodynamic analysis of a molecular chaperone binding to unfolded protein substrates.", BiochemistryFebruary,, 2010, 49(6), 1346-1353 [20073505], [doi[abs].

  40. DeArmond, PD; West, GM; Anbalagan, V; Fitzgerald, MC, "Discovery of Novel Cyclophilin A Ligands Using an H/D Exchange- and Mass Spectrometry-Based Strategy. Journal of Biomolecular Screening.", Journal of Biomolecular Screening, 2010, 15(9), 1051-1062 [20855564], [doi[abs].

  41. Hopper, ED; Pittman, AMC; Tucker, CL; Campa, MJ; Patz, EF; Fitzgerald, MC, "Hydrogen/deuterium exchange- and protease digestion-based screening assay for protein-ligand binding detection.", Anal ChemAugust,, 2009, 81(16), 6860-6867 [20337380], [doi[abs].

  42. Fitzgerald, MC; West, GM, "Painting proteins with covalent labels: what's in the picture?", Journal of the American Society for Mass SpectrometryJune,, 2009, 20(6), 1193-1206 (Cover Article.) [19269190], [doi[abs].

  43. Siburt, CJP; Roulhac, PL; Weaver, KD; Noto, JM; Mietzner, TA; Cornelissen, CN; Fitzgerald, MC; Crumbliss, AL, "Hijacking transferrin bound iron: protein-receptor interactions involved in iron transport in N. gonorrhoeae.", Metallomics : Integrated Biometal ScienceJanuary,, 2009, 1(3), 249-255 (Cover Article.) [20161024], [doi[abs].

  44. Fitzgerald, MC; Tang, L; Hopper, ED, "Chapter 6 Thermodynamic Analysis of Protein Folding and Ligand Binding by SUPREX", Comprehensive Analytical ChemistryDecember,, 2008, 52, 127-149, Elsevier [doi].

  45. Hopper, ED; Pittman, AMC; Fitzgerald, MC; Tucker, CL, "In vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase.", The Journal of Biological ChemistryNovember,, 2008, 283(45), 30493-30502 [18782763], [doi[abs].

  46. Hopper, ED; Roulhac, PL; Campa, MJ; Patz, EF; Fitzgerald, MC, "Throughput and efficiency of a mass spectrometry-based screening assay for protein-ligand binding detection.", Journal of the American Society for Mass SpectrometrySeptember,, 2008, 19(9), 1303-1311 [18653356], [doi[abs].

  47. Weaver, KD; Heymann, JJ; Mehta, A; Roulhac, PL; Anderson, DS; Nowalk, AJ; Adhikari, P; Mietzner, TA; Fitzgerald, MC; Crumbliss, AL, "Ga3+ as a mechanistic probe in Fe3+ transport: characterization of Ga3+ interaction with FbpA.", Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic ChemistryAugust,, 2008, 13(6), 887-898 [18461372], [doi[abs].

  48. West, GM; Tang, L; Fitzgerald, MC, "Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy.", Analytical ChemistryJune,, 2008, 80(11), 4175-4185 [18457414], [doi[abs].

  49. Roulhac, PL; Weaver, KD; Adhikari, P; Anderson, DS; DeArmond, PD; Mietzner, TA; Crumbliss, AL; Fitzgerald, MC, "Ex vivo analysis of synergistic anion binding to FbpA in Gram-negative bacteria.", BiochemistryApril,, 2008, 47(14), 4298-4305 [18338854], [doi[abs].

  50. Weaver, K.D., Heymann, J.J., Mehta, A., Roulhac, P.L., Anderson, D.S., Nowalk, A.J., Adhikari, P., Mietzner, T.A., Fitzgerald, M.C., and Crumbliss, A.L., "Ga+3 as a Mechanistic Probe of Fe+3 Transport: Characterization of Ga+3 Interaction with FbpA", Journal of Biological Inorganic Chemistry, 2008(13), 887-898.

  51. Tang, L; Roulhac, PL; Fitzgerald, MC, "H/D exchange and mass spectrometry-based method for biophysical analysis of multidomain proteins at the domain level.", Analytical ChemistryNovember,, 2007, 79(22), 8728-8739 [17948968], [doi[abs].

  52. Tang, L; Hopper, ED; Tong, Y; Sadowsky, JD; Peterson, KJ; Gellman, SH; Fitzgerald, MC, "H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding.", Analytical ChemistryAugust,, 2007, 79(15), 5869-5877 [17580981], [doi[abs].

  53. Williams, JC; Roulhac, PL; Roy, AG; Vallee, RB; Fitzgerald, MC; Hendrickson, WA, "Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex.", Proceedings of the National Academy of Sciences of the United States of AmericaJune,, 2007, 104(24), 10028-10033 [doi[abs].

  54. Frankel, BA; Tong, Y; Bentley, ML; Fitzgerald, MC; McCafferty, DG, "Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA.", BiochemistryJune,, 2007, 46(24), 7269-7278 [doi[abs].

  55. Frankel, BA; Tong, Y; Bentley, ML; Fitzgerald, MC; McCafferty, DG, "Analysis of Active Site Residues in the Staphylococcus aureus Transpeptidase SrtA Mutational", Biochemistry, 2007(46), 7269-7278.

  56. Dai, SY; Fitzgerald, MC, "Accuracy of SUPREX (stability of unpurified proteins from rates of H/D exchange) and MALDI mass spectrometry-derived protein unfolding free energies determined under non-EX2 exchange conditions.", Journal of the American Society for Mass SpectrometryNovember,, 2006, 17(11), 1535-1542 [16872837], [doi[abs].

  57. Yang, X; Wang, M; Fitzgerald, MC, "Direct analysis of backbone-backbone hydrogen bond formation in protein folding transition states.", Journal of Molecular BiologyOctober,, 2006, 363(2), 506-519 [16963082], [doi[abs].

  58. Dai, SY; Fitzgerald, MC, "A mass spectrometry-based probe of equilibrium intermediates in protein-folding reactions.", BiochemistryOctober,, 2006, 45(42), 12890-12897 [17042507], [doi[abs].

  59. Yang, X; Fitzgerald, MC, "Total chemical synthesis of the B1 domain of protein L from Peptostreptococcus magnus.", Bioorganic ChemistryJune,, 2006, 34(3), 131-141 [16690101], [doi[abs].

  60. Wang, M; Wales, TE; Fitzgerald, MC, "Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold.", Proceedings of the National Academy of Sciences of the United States of AmericaFebruary,, 2006, 103(8), 2600-2604 [16473949], [doi[abs].

  61. Cisneros, GA; Wang, M; Silinski, P; Fitzgerald, MC; Yang, W, "Theoretical and experimental determination on two substrates turned over by 4-oxalocrotonate tautomerase.", The Journal of Physical Chemistry AJanuary,, 2006, 110(2), 700-708 [16405343], [doi[abs].

  62. Tong, Y; Wuebbens, MM; Rajagopalan, KV; Fitzgerald, MC, "Thermodynamic analysis of subunit interactions in Escherichia coli molybdopterin synthase.", BiochemistryFebruary,, 2005, 44(7), 2595-2601 [15709772], [doi[abs].

  63. Dai, SY; Gardner, MW; Fitzgerald, MC, "Protocol for the thermodynamic analysis of some proteins using an H/D exchange- and mass spectrometry-based technique.", Analytical ChemistryJanuary,, 2005, 77(2), 693-697 [15649073], [doi[abs].

  64. Wang, M; Wales, TE; Fitzgerald, MC, "The Thermodynamics of Backbone-Backbone Hydrogen Bonds are Conserved ina Protein Fold", Proceedings of the National Academy of Sciences, Usa, 2005 (In Press.).

  65. Lin, SM; Haney, RP; Campa, MJ; Fitzgerald, MC; Patz, EF, "Characterising phase variations in MALDI-TOF data and correcting them by peak alignment.", Cancer Informatics, 2005, 1(1), 32-40 [19305630[abs].

  66. Dai, SY; Gardner, MW; Fitzgerald, MC, "An Improved Protocol for the SUPREX (Stability of Unpurified Proteins from Rates of H/D Exchange) Analysis of Some Proteins", Analytical Chemistry, 2005, 77(2), 693-697 [15649073], [doi[abs].

  67. Dai, SY; Gardner, MW; Fitzgerald, MC, "SUPREX (Stability of Unpurified Proteins from Rates of H/D Exchange) Analysis of Some Proteins", Analytical ChemistryDecember,, 2004 (Published on the Web.).

  68. Roulhac, PL; Powell, KD; Dhungana, S; Weaver, KD; Mietzner, TA; Crumbliss, AL; Fitzgerald, MC, "SUPREX (Stability of Unpurified Proteins from Rates of H/D Exchange) analysis of the thermodynamics of synergistic anion binding by ferric-binding protein (FbpA), a bacterial transferrin.", BiochemistryDecember,, 2004, 43(50), 15767-15774 [15595832], [doi[abs].

  69. Howard, BA; Zheng, Z; Campa, MJ; Wang, MZ; Sharma, A; Haura, E; Herndon, JE; Fitzgerald, MC; Bepler, G; Patz, EF, "Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer.", Lung Cancer (Amsterdam, Netherlands)December,, 2004, 46(3), 313-323 [15541816], [doi[abs].

  70. Yang, X; Wang, M; Fitzgerald, MC, "Analysis of protein folding and function using backbone modified proteins.", Bioorganic ChemistryOctober,, 2004, 32(5), 438-449 [15381405], [doi[abs].

  71. Wang, MZ; Shetty, JT; Howard, BA; Campa, MJ; Patz, EF; Fitzgerald, MC, "Thermodynamic analysis of cyclosporin a binding to cyclophilin a in a lung tumor tissue lysate.", Analytical ChemistryAugust,, 2004, 76(15), 4343-4348 [15283571], [doi[abs].

  72. Wales, TE; Richardson, JS; Fitzgerald, MC, "Facile chemical synthesis and equilibrium unfolding properties of CopG.", Protein Science : a Publication of the Protein SocietyJuly,, 2004, 13(7), 1918-1926 [15169951], [doi[abs].

  73. Cisneros, GA; Wang, M; Silinski, P; Fitzgerald, MC; Yang, W, "The protein backbone makes important contributions to 4-oxalocrotonate tautomerase enzyme catalysis: understanding from theory and experiment.", BiochemistryJune,, 2004, 43(22), 6885-6892 [15170325], [doi[abs].

  74. Powell, KD; Fitzgerald, MC, "High-throughput screening assay for the tunable selection of protein ligands.", Journal of Combinatorial ChemistryMarch,, 2004, 6(2), 262-269 [15002975], [doi[abs].

  75. Ma, L; Fitzgerald, MC, "A new H/D exchange- and mass spectrometry-based method for thermodynamic analysis of protein-DNA interactions.", Chemistry & BiologyDecember,, 2003, 10(12), 1205-1213 [14700628], [doi[abs].

  76. Ma, L; Fitzgerald, MC, "Thermodynamic Analysis of Protein-DNA Interactions using a New H/D Exchange- and Mass Spectrometry-Based Method", Chemistry & BiologyDecember,, 2003, 10.

  77. Powell, KD; Wang, MZ; Silinski, P; Ma, L; Wales, TE; Dai, SY; Warner, AH; Yang, X; Fitzgerald, MC, "The accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic stability of proteins", Analytica Chimica ActaOctober,, 2003, 496(1-2), 225-232, Elsevier BV (Invited Contribution for Young North American Faculty Special Issue.) [doi[abs].

  78. Campa, MJ; Fitzgerald, MC; Patz, EF, "Erratum: Exploring the proteome with MALDI-TOF (Editorial) (Proteomics 3: 9 (1659-1660))", ProteomicsOctober,, 2003, 3(10), 2067, WILEY [doi].

  79. Campa, MJ; Fitzgerald, MC; Patz, EF, "Exploring the proteome with MALDI-TOF", ProteomicsSeptember,, 2003, 3(9), 1659-1660.

  80. Howard, BA; Wang, MZ; Campa, MJ; Corro, C; Fitzgerald, MC; Patz, EF, "Identification and validation of a potential lung cancer serum biomarker detected by matrix-assisted laser desorption/ionization-time of flight spectra analysis.", ProteomicsSeptember,, 2003, 3(9), 1720-1724 [12973732], [doi[abs].

  81. Wang, MZ; Howard, B; Campa, MJ; Patz, EF; Fitzgerald, MC, "Analysis of human serum proteins by liquid phase isoelectric focusing and matrix-assisted laser desorption/ionization-mass spectrometry.", ProteomicsSeptember,, 2003, 3(9), 1661-1666 [12973721], [doi[abs].

  82. Ercole, F; FitzGerald, M; Perera, S; Ede, N; Riley, P; Campbell, R, "A combinatorial approach in designing hydrophilic surfaces for solid-phase peptide synthesis", Journal of Applied Polymer ScienceJuly,, 2003, 89(12), 3371-3378, WILEY [doi[abs].

  83. Silinski, P; Fitzgerald, MC, "Comparative analysis of two different amide-to-ester bond mutations in the beta-sheet of 4-oxalocrotonate tautomerase.", BiochemistryJune,, 2003, 42(21), 6620-6630 [12767246], [doi[abs].

  84. Powell, KD; Fitzgerald, MC, "Accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic properties of protein-peptide complexes.", BiochemistryMay,, 2003, 42(17), 4962-4970 [12718538], [doi[abs].

  85. Campa, MJ; Wang, MZ; Howard, B; Fitzgerald, MC; Patz, EF, "Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer.", Cancer ResearchApril,, 2003, 63(7), 1652-1656 [12670919[abs].

  86. Wu, Z; Ercole, F; FitzGerald, M; Perera, S; Riley, P; Campbell, R; Pham, Y; Rea, P; Sandanayake, S; Mathieu, MN; Bray, AM; Ede, NJ, "Synthesis of tetrahydro-1,4-benzodiazepine-2-ones on hydrophilic polyamide SynPhase lanterns.", Journal of Combinatorial ChemistryMarch,, 2003, 5(2), 166-171 [doi[abs].

  87. Campa, MJ; Wang, MZ; Howard, B; Fitzgerald, MC; Patz, EF, "Protein Expression Profiling Identifies MIF and Cyclophilin A as Potential Molecular Targets in Non-Small Cell Lung Cancer", Cancer Research, 2003, 63(7), 1652-1656 [12670919[abs].

  88. Fitzgerald, MC; Powell, KD; Wang, MZ; Ma, L; Ghaemmaghami, S; Oas, TG, "A general mass spectrometry-based method for the quantitation of protein-ligand binding interactions in solution", Proceedings 50th Asms Conference on Mass Spectrometry and Allied TopicsDecember,, 2002, 395-396 [abs].

  89. Powell, KD; Fitzgerald, MC, "Quantitative determination of protein-peptide binding constants using a new, MALDI- and H/D-exchange based technique", Proceedings 50th Asms Conference on Mass Spectrometry and Allied TopicsDecember,, 2002, 445-446 [abs].

  90. Ghaemmaghami, S; Fitzgerald, MC; Oas, TG, "Quantitative protein stability measurement in living bacteria", Proceedings 50th Asms Conference on Mass Spectrometry and Allied TopicsDecember,, 2002, 109-110 [abs].

  91. Ma, L; Powell, KD; Fitzgerald, MC, "A new H/D exchange- and MALDI-based assay for the quantitative analysis of protein-DNA interactions in solution", Proceedings 50th Asms Conference on Mass Spectrometry and Allied TopicsDecember,, 2002, 471-472 [abs].

  92. Wang, MZ; Campa, M; Howard, BA; Patz, EF; Fitzgerald, MC, "A fractionation protocol to reduce signal suppression effects in the MALDI analysis of blood proteins", Proceedings 50th Asms Conference on Mass Spectrometry and Allied TopicsDecember,, 2002, 587-588 [abs].

  93. Powell, KD; Ghaemmaghami, S; Wang, MZ; Ma, L; Oas, TG; Fitzgerald, MC, "A general mass spectrometry-based assay for the quantitation of protein-ligand binding interactions in solution.", Journal of the American Chemical SocietySeptember,, 2002, 124(35), 10256-10257 [12197709], [doi[abs].

  94. Silinski, P; Fitzgerald, MC, "A stable dimer in the pH-induced equilibrium unfolding of the homo-hexameric enzyme 4-oxalocrotonate tautomerase (4-OT).", BiochemistryApril,, 2002, 41(13), 4480-4491 [11914096], [doi[abs].

  95. Powell, KD; Wales, TE; Fitzgerald, MC, "Thermodynamic stability measurements on multimeric proteins using a new H/D exchange- and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry-based method.", Protein Science : a Publication of the Protein SocietyApril,, 2002, 11(4), 841-851 [11910027], [doi[abs].

  96. Wales, TE; Fitzgerald, MC, "The energetic contribution of backbone--backbone hydrogen bonds to the thermodynamic stability of a hyperstable P22 Arc repressor mutant.", Journal of the American Chemical SocietyAugust,, 2001, 123(31), 7709-7710 [11480998], [doi].

  97. Powell, KD; Fitzgerald, MC, "Measurements of protein stability by H/D exchange and matrix-assisted laser desorption/ionization mass spectrometry using picomoles of material.", Analytical ChemistryJuly,, 2001, 73(14), 3300-3304 [11476229], [doi[abs].

  98. Silinski, P; Allingham, MJ; Fitzgerald, MC, "Guanidine-induced equilibrium unfolding of a homo-hexameric enzyme 4-oxalocrotonate tautomerase (4-OT).", BiochemistryApril,, 2001, 40(14), 4493-4502 [11284706], [doi[abs].

  99. Moss, JA; Silinski, P; Fitzgerald, MC, "Mapping tertiary interactions in protein folding reactions: a novel mass spectrometry- and chemical synthesis-based approach.", Fresenius' Journal of Analytical ChemistryFebruary,, 2001, 369(3-4), 252-257 (Invited Contribution for Special North American Authors Issue.) [11293701], [doi[abs].

  100. Wang, MZ; Fitzgerald, MC, "A solid sample preparation method that reduces signal suppression effects in the MALDI analysis of peptides.", Analytical ChemistryFebruary,, 2001, 73(3), 625-631 [11217772], [doi[abs].

  101. Whales, T.E. and Fitzgerald, M.C., "The Energetic Contribution of Backbone-Backbone Hydrogen Bonds to the Thermodynamic Stability of a Hyperstable P22 Arc Repressor Mutant", Journal of the American Chemical Society, 2001, 123, 7709-7710.

  102. Powell, KD; Fitzgerald, MC, "High Sensitivity Measurements of Protein Stability by H/D Exchange and Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass spectrometry.", Analytical Chemistry, 2001, 73(14), 3300-3304 [11476229[abs].

  103. Ghaemmaghami, S; Fitzgerald, MC; Oas, TG, "A quantitative, high-throughput screen for protein stability.", Proceedings of the National Academy of Sciences of the United States of AmericaJuly,, 2000, 97(15), 8296-8301 [10890887], [doi[abs].

  104. Nakhle, BM; Silinski, P; Fitzgerald, MC, "Identification of an essential backbone amide bond in the folding and stability of a multimeric enzyme", Journal of the American Chemical Society, 2000, 122(34), X, American Chemical Society (ACS) [doi[abs].

  105. Winston, RL; Fitzgerald, MC, "Concentration and desalting of protein samples for mass spectrometry analysis.", Analytical BiochemistryAugust,, 1998, 262(1), 83-85 [doi].

  106. Stamps, SL; Fitzgerald, MC; Whitman, CP, "Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor.", BiochemistryJuly,, 1998, 37(28), 10195-10202 [doi[abs].

  107. Beeston, RF; Aldridge, WS; Treadway, JA; Fitzgerald, MC; DeGraff, BA; Stitzel, SE, "Synthesis, Characterization, and Photochemical/Photophysical Properties of Ruthenium(II) Complexes with Hexadentate Bipyridine and Phenanthroline Ligands", Inorganic ChemistryJanuary,, 1998, 37(17), 4368-4379, American Chemical Society (ACS) [doi[abs].

  108. Johnson, WH; Czerwinski, RM; Fitzgerald, MC; Whitman, CP, "Inactivation of 4-oxalocrotonate tautomerase by 2-oxo-3-pentynoate.", BiochemistryDecember,, 1997, 36(50), 15724-15732 [doi[abs].

  109. Fitzgerald, MC; Laco, GS; Elder, JH; Kent, SB, "A continuous fluorometric assay for the feline immunodeficiency virus protease.", Analytical BiochemistryDecember,, 1997, 254(2), 226-230 [doi[abs].

  110. Carrasco, MR; Fitzgerald, MC; Oda, Y; Kent, SBH, "Direct monitoring of organic reactions on polymeric supports", Tetrahedron LettersSeptember,, 1997, 38(36), 6331-6334, Elsevier BV [doi[abs].

  111. Dawson, PE; Fitzgerald, MC; Muir, TW; Kent, SBH, "Methods for the chemical synthesis and readout of self-encoded arrays of polypeptide analogues", Journal of the American Chemical SocietyAugust,, 1997, 119(34), 7917-7927, American Chemical Society (ACS) [doi[abs].

  112. Winston, RL; Fitzgerald, MC, "Mass spectrometry as a readout of protein structure and function.", Mass Spectrometry ReviewsJuly,, 1997, 16(4), 165-179 [doi[abs].

  113. Laco, GS; Fitzgerald, MC; Morris, GM; Olson, AJ; Kent, SB; Elder, JH, "Molecular analysis of the feline immunodeficiency virus protease: generation of a novel form of the protease by autoproteolysis and construction of cleavage-resistant proteases.", Journal of VirologyJuly,, 1997, 71(7), 5505-5511 [doi[abs].

  114. Muir, TW; Dawson, PE; Fitzgerald, MC; Kent, SB, "Protein signature analysis: a practical new approach for studying structure-activity relationships in peptides and proteins.", Methods in EnzymologyJanuary,, 1997, 289, 545-564 [doi].

  115. Fitzgerald, MC; Laco, GS; Elder, JH; Kent, SBH, "A Continuous Fluorometric Assay for the FIV Protease", Analytical Biochemistry, 1997, 254(2), 226-230 [doi[abs].

  116. Qian, X; Morís-Varas, F; Fitzgerald, MC; Wong, CH, "C2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases.", Bioorganic & Medicinal ChemistryDecember,, 1996, 4(12), 2055-2069 [doi[abs].

  117. Muir, TW; Dawson, PE; Fitzgerald, MC; Kent, SB, "Probing the chemical basis of binding activity in an SH3 domain by protein signature analysis.", Chemistry & BiologyOctober,, 1996, 3(10), 817-825 [doi[abs].

  118. Fitzgerald, MC; Siuzdak, G, "Biochemical mass spectrometry: worth the weight?", Chemistry & BiologySeptember,, 1996, 3(9), 707-715 [doi[abs].

  119. Fitzgerald, MC; Chernushevich, I; Standing, KG; Whitman, CP; Kent, SB, "Probing the oligomeric structure of an enzyme by electrospray ionization time-of-flight mass spectrometry.", Proceedings of the National Academy of Sciences of the United States of AmericaJuly,, 1996, 93(14), 6851-6856 [doi[abs].

  120. Fitzgerald, MC; Harris, K; Shevlin, CG; Siuzdak, G, "Direct characterization of solid phase resin-bound molecules by mass spectrometry", Bioorganic & Medicinal Chemistry LettersApril,, 1996, 6(8), 979-982, Elsevier BV [doi[abs].

  121. Qian, X; Moris Varas, F; Fitzgerald, MC; Wong, CH, "C2-Symmetrical Tetrahydroxyazepenes as Inhibitors of Glyosidases and HIV/FIV Proteases", Bioorganic & Medicinal Chemistry, 1996, 4(12), 2055-2069.

  122. Fitzgerald, MC; Smith, LM, "Mass spectrometry of nucleic acids: the promise of matrix-assisted laser desorption-ionization (MALDI) mass spectrometry.", Annual Review of Biophysics and Biomolecular StructureJanuary,, 1995, 24, 117-140 [doi[abs].

  123. Fitzgerald, MC; Kent, SBH; Chernushevich, I; Standing, KG; Whitman, CP, "Total Chemical Synthesis and Catalytic Properties of the Enzyme Enantiomers L- and D-4-Oxalocrotonate Tautomerase", Journal of the American Chemical SocietyJanuary,, 1995, 117(45), 11075-11080, American Chemical Society (ACS) [doi[abs].

  124. Zhu, L; Parr, GR; Fitzgerald, MC; Nelson, CM; Smith, LM, "Oligodeoxynucleotide Fragmentation in MALDI/TOF Mass Spectrometry Using 355-nm Radiation", Journal of the American Chemical SocietyJanuary,, 1995, 117(22), 6048-6056, American Chemical Society (ACS) [doi[abs].

  125. Shen, CL; Fitzgerald, MC; Murphy, RM, "Effect of acid predissolution on fibril size and fibril flexibility of synthetic beta-amyloid peptide.", Biophysical JournalSeptember,, 1994, 67(3), 1238-1246 [doi[abs].

  126. Fitzgerald, MC; Parr, GR; Smith, LM, "Basic matrices for the matrix-assisted laser desorption/ionization mass spectrometry of proteins and oligonucleotides.", Analytical ChemistryNovember,, 1993, 65(22), 3204-3211 [doi[abs].

  127. Fitzgerald, MC; Zhu, L; Smith, LM, "The analysis of mock DNA sequencing reactions using matrix‐assisted laser desorption/ionization mass spectrometry", Rapid Communications in Mass Spectrometry : RcmJanuary,, 1993, 7(10), 895-897, WILEY [doi[abs].

  128. Fitzgerald, MC; Skowron, P; Van Etten, JL; Smith, LM; Mead, DA, "Rapid shotgun cloning utilizing the two base recognition endonuclease CviJI.", Nucleic Acids ResJuly,, 1992, 20(14), 3753-3762 [doi[abs].

  129. Parr, GR; Fitzgerald, MC; Smith, LM, "Matrix‐assisted laser desorption/ionization mass spectrometry of synthetic oligodeoxyribonucleotides", Rapid Communications in Mass Spectrometry : RcmJanuary,, 1992, 6(6), 369-372, WILEY [doi[abs].

  130. Beeston, RF; Larson, SL; Fitzgerald, MC, "Ground- and Excited-State Properties of a Photostable Hemicage Ruthenium(II) Polypyridine Complex", Inorganic ChemistryNovember,, 1989, 28(23), 4187-4189, American Chemical Society (ACS) [doi].

Chapter in Book

  1. Fitzgerald, M.C., Tang, L., and Hopper, E.D, "Thermodynamic Analysis of Protein Folding and Ligand Binding by SUPREX", in Comprehensive Analytical Chemistry; Protein Mass Spectrometry, Julian P. Whitelegge, edited by D. Barcelo , 2008, 52, 127-149, Elsevier BV: Elsivier (Will be released in 2009.).

  2. Fitzgerald, M.C., Dai, S., and Tong, Y., "SUPREX Analysis of Protein Folding and Function.", in Encyclopedia of Mass Spectrometry, edited by M.L. Gross and R.M. Caprioli , 2007, 6, 794-802.

  3. Fitzgerald, M.C., Tang, L., and Hopper, E.D., "Thermodynamic Analysis of Protein Folding and Ligand Binding by SUPREX", in Protein Mass Spectrometry, edited by J. Whitelegge , 2007, Elsevier, Inc. (In Press.).

  4. Winston, R.L. and Fitzgerald, M.C., "Combinatorial Chemistry and the Structure-Function Analysis of Proteins", in Peptide and Protein Drug Analysis, edited by Reid, R.E. , 2000, 101, 207-235, Marcel Dekker, Inc., New York.

  5. Fitzgerald, M.C. and Kent, S.B.H., "A General Approach to Deciphering How Proteins Work Using Synthetic Chemistry and Mass Spectrometry", in NATO ASI Series: New Methods for the Study of Molecular Aggregates, edited by Standing, K.G. and Ens, W. , 1998, Kluwer Academic Publishers, The Netherlands.

  6. Fitzgerald, M.C. and Kent, S.B.H., "Total Chemical Synthesis of Proteins", in Bioorganic Chemistry: Peptides and Proteins, edited by Hecht, S.M. , 1998, 65-99, Oxford University Press, New York.

  7. Muir, T.M., Dawson, P.E., Fitzgerald, M.C., and Kent, S.B.H., "Protein Signature Analysis: A Practical New Approach for Studying Structure-Activity Relationships in Peptide and Proteins", in Methods in Enzymology: Solid-Phase Peptide Synthesis, edited by Fields, G.B. , 1997, 289, 545-564, Academic Press, New York.

Other

  1. PATENT: Oas, T.G., Ghaemmaghami, S., Powell, K.D., and Fitzgerald, M.C., "Quantitative, High-Throughput Screening Method for Protein Stability; U.S. Patent Divisional Application Serial No. 11/634,019, based on U.S. Patent No. 6,734,023. Issued August, 2008", 2008.