Publications [#232590] of Michael C. Fitzgerald

Journal Articles

  1. Wu, Z; Ercole, F; FitzGerald, M; Perera, S; Riley, P; Campbell, R; Pham, Y; Rea, P; Sandanayake, S; Mathieu, MN; Bray, AM; Ede, NJ, "Synthesis of tetrahydro-1,4-benzodiazepine-2-ones on hydrophilic polyamide SynPhase lanterns.", Journal of combinatorial chemistryMarch,, 2003, 5(2), 166-171 [doi].
    (last updated on 2024/04/24)

    Abstract:
    Solid-phase synthesis is greatly dependent on the solid support. Here, we report the use of a new hydrophilic grafted surface on SynPhase lanterns in solid-phase organic chemistry. A convenient and facile solid-phase synthesis of disubstituted 1,4-benzodiazepine-2-ones on polyamide SynPhase lanterns is described. The key step of the synthesis involved a reduction-cyclization of a nitroaryl methyl ester with a mixture of tin(II) chloride dihydrate and ammonium acetate in water and ethanol at elevated temperature to give the desired target compounds. A library of 21 disubstituted 1,4-benzodiazepine-2-ones was prepared.