Publications [#234695] of Ross A. Widenhoefer

Journal Articles

  1. Zhang, Z; Bender, CF; Widenhoefer, RA, "Gold(I)-catalyzed enantioselective hydroamination of N-allenyl carbamates.", Organic lettersJuly,, 2007, 9(15), 2887-2889 [17595096], [doi].
    (last updated on 2024/04/24)

    Abstract:
    Treatment of the N-4,5-hexadienyl carbamate 2a with a catalytic 1:2 mixture of [(S)-1]Au2Cl2 [(S)-1 = (S)-3,5-t-Bu-4-MeO-MeOBIPHEP] and AgClO4 in m-xylene at -40 degrees C for 24 h led to isolation of 2-vinylpyrrolidine 3a in 97% yield with 81% ee. Gold(I)-catalyzed enantioselective hydroamination was effective for a number of carbamate groups and tolerated terminal disubstitutution of the allenyl moiety.