Publications of Steven Malcolmson

Journal Articles

  1. Ma, X; Malcolmson, SJ, "Palladium-Catalyzed Regiodivergent Three-Component Alkenylamination of 1,3-Dienes with Alkyl and Aryl Amines.", Journal of the American Chemical SocietyDecember,, 2023, 145(50), 27680-27689 [doi] [abs].

  2. Zhou, P; Shao, X; Malcolmson, SJ, "A Diastereodivergent and Enantioselective Approach to syn- and anti-Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines That Furnish Allylic Amines.", Journal of the American Chemical SocietySeptember,, 2021, 143(34), 13999-14008 [doi] [abs].

  3. Zhou, P; Shao, X; Malcolmson, S, "A Diastereodivergent and Enantioselective Approach to syn- and anti-Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines that Furnish Allylic Amines"July,, 2021 [doi] [abs].

  4. Malcolmson, SJ, "Racing against unwanted isomerization.", Science (New York, N.Y.)January,, 2021, 371(6527), 345-346 [doi].

  5. Zhou, P; Shao, X; Malcolmson, S, "A Diastereodivergent and Enantioselective Approach to syn- and anti-Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines that Furnish Allylic Amines", 2021 [doi] [abs].

  6. Onyeagusi, CI; Malcolmson, SJ, "Strategies for the Catalytic Enantioselective Synthesis of α-Trifluoromethyl Amines.", ACS catalysisNovember,, 2020, 10(21), 12507-12536, American Chemical Society (ACS) [doi] [abs].

  7. Colell, JFP; Logan, AWJ; Zhou, Z; Lindale, JR; Laasner, R; Shchepin, RV; Chekmenev, EY; Blum, V; Warren, WS; Malcolmson, SJ; Theis, T, "Rational ligand choice extends the SABRE substrate scope.", Chemical communications (Cambridge, England)August,, 2020, 56(65), 9336-9339 [doi] [abs].

  8. Adamson, NJ; Park, S; Zhou, P; Nguyen, AL; Malcolmson, SJ, "Enantioselective Construction of Quaternary Stereogenic Centers by the Addition of an Acyl Anion Equivalent to 1,3-Dienes.", Organic lettersMarch,, 2020, 22(5), 2032-2037 [doi] [abs].

  9. Onyeagusi, CI; Shao, X; Malcolmson, SJ, "Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes.", Organic lettersFebruary,, 2020, 22(4), 1681-1685 [doi] [abs].

  10. Adamson, NJ; Malcolmson, SJ, "Catalytic Enantio- And Regioselective Addition of Nucleophiles in the Intermolecular Hydrofunctionalization of 1,3-Dienes", ACS CatalysisJanuary,, 2020, 10(2), 1060-1076 [doi] [abs].

  11. Onyeagusi, C; Shao, X; Malcolmson, S, "Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes", 2020 [doi] [abs].

  12. Shao, X; Malcolmson, SJ, "Catalytic Enantio- and Diastereoselective Cyclopropanation of 2-Azadienes for the Synthesis of Aminocyclopropanes Bearing Quaternary Carbon Stereogenic Centers.", Organic lettersSeptember,, 2019, 21(18), 7380-7385 [doi] [abs].

  13. Malcolmson, SJ; Li, K; Shao, X, "2-Azadienes as Enamine Umpolung Synthons for the Preparation of Chiral Amines.", Synlett : accounts and rapid communications in synthetic organic chemistryJuly,, 2019, 30(11), 1253-1268 [doi] [abs].

  14. Adamson, NJ; Jeddi, H; Malcolmson, SJ, "Preparation of Chiral Allenes through Pd-Catalyzed Intermolecular Hydroamination of Conjugated Enynes: Enantioselective Synthesis Enabled by Catalyst Design.", Journal of the American Chemical SocietyMay,, 2019, 141(21), 8574-8583 [doi] [abs].

  15. Park, S; Adamson, NJ; Malcolmson, SJ, "Brønsted acid and Pd-PHOX dual-catalysed enantioselective addition of activated C-pronucleophiles to internal dienes.", Chemical scienceMay,, 2019, 10(19), 5176-5182 [doi] [abs].

  16. Daniel, PE; Onyeagusi, CI; Ribeiro, AA; Li, K; Malcolmson, SJ, "Palladium-Catalyzed Synthesis of α-Trifluoromethyl Benzylic Amines via Fluoroarylation of gem-Difluoro-2-azadienes Enabled by Phosphine-Catalyzed Formation of an Azaallyl-Silver Intermediate.", ACS catalysisJanuary,, 2019, 9(1), 205-210, American Chemical Society (ACS) [doi] [abs].

  17. Park, S; Malcolmson, SJ, "Development and Mechanistic Investigations of Enantioselective Pd-Catalyzed Intermolecular Hydroaminations of Internal Dienes", ACS CatalysisSeptember,, 2018, 8(9), 8468-8476, American Chemical Society (ACS) [doi] [abs].

  18. Shao, X; Li, K; Malcolmson, SJ, "Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines.", Journal of the American Chemical SocietyJune,, 2018, 140(23), 7083-7087 [doi] [abs].

  19. Adamson, NJ; Wilbur, KCE; Malcolmson, SJ, "Enantioselective Intermolecular Pd-Catalyzed Hydroalkylation of Acyclic 1,3-Dienes with Activated Pronucleophiles.", Journal of the American Chemical SocietyFebruary,, 2018, 140(8), 2761-2764 [doi] [abs].

  20. Li, K; Shao, X; Tseng, L; Malcolmson, SJ, "2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones.", Journal of the American Chemical SocietyJanuary,, 2018, 140(2), 598-601 [doi] [abs].

  21. Shen, K; Logan, AWJ; Colell, JFP; Bae, J; Ortiz, GX; Theis, T; Warren, WS; Malcolmson, SJ; Wang, Q, "Cover Picture: Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization (Angew. Chem. Int. Ed. 40/2017)", Angewandte Chemie International EditionSeptember,, 2017, 56(40), 12015-12015, Wiley [doi].

  22. Shen, K; Logan, AWJ; Colell, JFP; Bae, J; Ortiz, GX; Theis, T; Warren, WS; Malcolmson, SJ; Wang, Q, "Titelbild: Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization (Angew. Chem. 40/2017)", Angewandte ChemieSeptember,, 2017, 129(40), 12179-12179, Wiley [doi].

  23. Shen, K; Logan, AWJ; Colell, JFP; Bae, J; Ortiz, GX; Theis, T; Warren, WS; Malcolmson, SJ; Wang, Q, "Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization.", Angewandte Chemie (International ed. in English)September,, 2017, 56(40), 12112-12116, Wiley [doi] [abs].

  24. Li, K; Weber, AE; Tseng, L; Malcolmson, SJ, "Diastereoselective and Enantiospecific Synthesis of 1,3-Diamines via 2-Azaallyl Anion Benzylic Ring-Opening of Aziridines.", Organic lettersAugust,, 2017, 19(16), 4239-4242 [doi] [abs].

  25. Daniel, PE; Weber, AE; Malcolmson, SJ, "Umpolung Synthesis of 1,3-Amino Alcohols: Stereoselective Addition of 2-Azaallyl Anions to Epoxides.", Organic lettersJuly,, 2017, 19(13), 3490-3493 [doi] [abs].

  26. Colell, JFP; Emondts, M; Logan, AWJ; Shen, K; Bae, J; Shchepin, RV; Ortiz, GX; Spannring, P; Wang, Q; Malcolmson, SJ; Chekmenev, EY; Feiters, MC; Rutjes, FPJT; Blümich, B; Theis, T; Warren, WS, "Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange.", Journal of the American Chemical SocietyJune,, 2017, 139(23), 7761-7767 [doi] [abs].

  27. Adamson, NJ; Hull, E; Malcolmson, SJ, "Enantioselective Intermolecular Addition of Aliphatic Amines to Acyclic Dienes with a Pd-PHOX Catalyst.", Journal of the American Chemical SocietyMay,, 2017, 139(21), 7180-7183 [doi] [abs].

  28. Colell, JFP; Logan, AWJ; Zhou, Z; Shchepin, RV; Barskiy, DA; Ortiz, GX; Wang, Q; Malcolmson, SJ; Chekmenev, EY; Warren, WS; Theis, T, "Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange.", The journal of physical chemistry. C, Nanomaterials and interfacesMarch,, 2017, 121(12), 6626-6634 [doi] [abs].

  29. Logan, AWJ; Theis, T; Colell, JFP; Warren, WS; Malcolmson, SJ, "Hyperpolarization of Nitrogen-15 Schiff Bases by Reversible Exchange Catalysis with para-Hydrogen.", Chemistry (Weinheim an der Bergstrasse, Germany)July,, 2016, 22(31), 10777-10781 [doi] [abs].

  30. Theis, T; Ortiz, GX; Logan, AWJ; Claytor, KE; Feng, Y; Huhn, WP; Blum, V; Malcolmson, SJ; Chekmenev, EY; Wang, Q; Warren, WS, "Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal 15N2-diazirine molecular tags", Science AdvancesMarch,, 2016, 2(3), e1501438 [doi] [abs].

  31. Malcolmson, SJ; Young, TS; Ruby, JG; Skewes-Cox, P; Walsh, CT, "The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds.", Proceedings of the National Academy of Sciences of the United States of AmericaMay,, 2013, 110(21), 8483-8488 [23650400], [doi] [abs].

  32. Lichtscheidl, AG; Ng, VWL; Müller, P; Takase, MK; Schrock, RR; Malcolmson, SJ; Meek, SJ; Li, B; Kiesewetter, ET; Hoveyda, AH, "Bipyridine Adducts of Molybdenum Imido Alkylidene and Imido Alkylidyne Complexes.", OrganometallicsJune,, 2012, 31(12), 4558-4564 [22899875], [doi] [abs].

  33. Walsh, CT; Malcolmson, SJ; Young, TS, "Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks.", ACS chemical biologyMarch,, 2012, 7(3), 429-442 [22206579], [doi] [abs].

  34. Crawford, JM; Mahlstedt, SA; Malcolmson, SJ; Clardy, J; Walsh, CT, "Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis.", Chemistry & biologySeptember,, 2011, 18(9), 1102-1112 [21944749], [doi] [abs].

  35. Zhang, W; Ntai, I; Bolla, ML; Malcolmson, SJ; Kahne, D; Kelleher, NL; Walsh, CT, "Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics.", Journal of the American Chemical SocietyApril,, 2011, 133(14), 5240-5243 [21417270], [doi] [abs].

  36. Hoveyda, AH; Malcolmson, SJ; Meek, SJ; Zhugralin, AR, "Catalytic Enantioselective Olefin Metathesis and Natural Product Synthesis"June,, 2010, 343-348, Wiley-VCH Verlag GmbH & Co. KGaA [doi].

  37. Ji, JX; Chan, ASC; Helmchen, G; Kazmaier, U; Förster, S; Ojima, I; Kaloko, JJ; Chaterpaul, SJ; Teng, YHG; Lin, CF; Mikami, K; Aikawa, K; Hoveyda, AH; Malcolmson, SJ; Meek, SJ; Zhugralin, AR, "Asymmetric Carbon-Carbon Bond-Forming Reactions"March,, 2010, 437-770, JOHN WILEY & SONS INC [doi].

  38. Hoveyda, AH; Malcolmson, SJ; Meek, SJ; Zhugralin, AR, "Catalytic enantioselective olefin metathesis in natural product synthesis. Chiral metal-based complexes that deliver high enantioselectivity and more.", Angewandte Chemie (International ed. in English)January,, 2010, 49(1), 34-44 [19967680], [doi] [abs].

  39. Meek, SJ; Malcolmson, SJ; Li, B; Schrock, RR; Hoveyda, AH, "The significance of degenerate processes to enantioselective olefin metathesis reactions promoted by stereogenic-at-Mo complexes.", Journal of the American Chemical SocietyNovember,, 2009, 131(45), 16407-16409 [19842640], [doi] [abs].

  40. Harvey, JS; Malcolmson, SJ; Dunne, KS; Meek, SJ; Thompson, AL; Schrock, RR; Hoveyda, AH; Gouverneur, V, "Enantioselective synthesis of P-stereogenic phosphinates and phosphine oxides by molybdenum-catalyzed asymmetric ring-closing metathesis.", Angewandte Chemie (International ed. in English)January,, 2009, 48(4), 762-766 [19101976], [doi].

  41. Sattely, ES; Meek, SJ; Malcolmson, SJ; Schrock, RR; Hoveyda, AH, "Design and stereoselective preparation of a new class of chiral olefin metathesis catalysts and application to enantioselective synthesis of quebrachamine: catalyst development inspired by natural product synthesis.", Journal of the American Chemical SocietyJanuary,, 2009, 131(3), 943-953 [19113867], [doi] [abs].

  42. Malcolmson, SJ; Meek, SJ; Sattely, ES; Schrock, RR; Hoveyda, AH, "Highly efficient molybdenum-based catalysts for enantioselective alkene metathesis.", NatureDecember,, 2008, 456(7224), 933-937 [19011612], [doi] [abs].

  43. Lee, A-L; Malcolmson, SJ; Puglisi, A; Schrock, RR; Hoveyda, AH, "Enantioselective synthesis of cyclic enol ethers and all-carbon quaternary stereogenic centers through catalytic asymmetric ring-closing metathesis.", Journal of the American Chemical SocietyApril,, 2006, 128(15), 5153-5157 [16608351], [doi] [abs].

Chapter in Book

  1. Hoveyda, AH; Khan, RKM; Torker, S; Malcolmson, SJ, "Catalyst-Controlled Stereoselective Olefin Metathesis", in Handbook of Metathesis: Second EditionJanuary,, 2015, 2-3, 503-562, Wiley-VCH Verlag GmbH & Co. KGaA [doi] [abs].