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Publications [#323855] of David McAdams

Journal Articles

  1. McAdams, D, Resistance diagnosis and the changing epidemiology of antibiotic resistance., Annals of the New York Academy of Sciences, vol. 1388 no. 1 (January, 2017), pp. 5-17 [doi]
    (last updated on 2020/10/19)

    Widespread adoption of point-of-care resistance diagnostics (POCRD) reduces ineffective antibiotic use but could increase overall antibiotic use. Indeed, in the context of a standard susceptible-infected epidemiological model with a single antibiotic, POCRD accelerates the rise of resistance in the disease-causing bacterial population. When multiple antibiotics are available, however, POCRD may slow the rise of resistance even as more patients receive antibiotic treatment, belying the conventional wisdom that antibiotics are "exhaustible resources" whose increased use necessarily promotes the rise of resistance.

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