Publications [#253790] of David C. Rubin

Journal Articles

1. Rubin, DC, Frontal-striatal circuits in cognitive aging: Evidence for caudate involvement, vol. 6 no. 4 (December, 1999), pp. 241-259, Informa UK Limited [repository], [doi]
   (last updated on 2024/04/18)

   Abstract:
   Changes in cognition with aging have been claimed to be due in large part to a decline in frontal lobe function. However, at our present state of knowledge, the emphasis on the frontal lobes to the exclusion of the rest of the frontal-striatal circuits of which they are a part is unwarranted. To argue this point, I consider another anatomical candidate within these circuits, the caudate. Evidence is presented that the caudate decreases in size with age as much as the frontal lobes and that damage to either the frontal lobes or the caudate is accompanied by declines in inhibitory processes, executive control, and cognitive speed similar to those seen in normal aging. Separating the unique contributions of the frontal lobes and the caudate to these circuits is difficult but should be the focus of future studies of the biological basis of cognitive aging.