Nicolas Buchler, Assistant Professor of Biology and Physics  

Nicolas Buchler

Office Location: 2353A CIEMAS
Office Phone: (919) 699-8209
Email Address:
Web Page:

Biological physics
Nonlinear dynamics and complex systems
Chemical Physics

PhD, University of Michigan, 2001
BS, University of California, San Diego, 1995

Teaching (Fall 2015):

  • Physics 414.01, Introduction to biophysics Synopsis
    Physics 154, MW 11:45 AM-01:00 PM

Representative Publications   (More Publications)

  1. M Zhou, W Wang, S Karapetyan, M Mwimba, J Marqués, NE Buchler, X Dong, Redox rhythm reinforces the circadian clock to gate immune response, Nature, vol. 523 (June, 2015), pp. 472-476 [doi]  [abs].
  2. Y Tanouchi, A Pai, H Park, S Huang, R Stamatov, NE Buchler, L You, A noisy linear map underlies oscillations in cell size and gene expression in bacteria., Nature, vol. 523 (June, 2015), pp. 357-360 [html], [doi]  [abs].
  3. A Mazo-Vargas, H Park, M Aydin, NE Buchler, Measuring fast gene dynamics in single cells with time-lapse luminescence microscopy, Molecular Biology of the Cell, vol. 25 no. 22 (November, 2014), pp. 3699-708 [long], [doi]  [abs].
  4. FR Cross, NE Buchler, JM Skotheim, Evolution of networks and sequences in eukaryotic cell cycle control., Philosophical Transactions of the Royal Society of London. Series B, Biological sciences, vol. 366 no. 1584 (December, 2011), pp. 3532-44 [doi]  [abs].
  5. NE Buchler, FR Cross, Protein sequestration generates a flexible ultrasensitive response in a genetic network., Molecular Systems Biology, vol. 5 (2009), pp. 272 [doi]  [abs].
  6. NE Buchler, M Louis, Molecular titration and ultrasensitivity in regulatory networks., Journal of Molecular Biology, vol. 384 no. 5 (December, 2008), pp. 1106-19 [doi]  [abs].

Bistable and oscillatory dynamics in regulatory networks are essential for patterning, cell proliferation, and cell differentiation in biological systems. My lab takes an interdisciplinary approach (theory and experiment; physics and biology; synthetic and systems biology) to understand the diverse molecular and evolutionary mechanisms by which thresholds, combinatorial control, bistability, and oscillation have evolved in biological systems.

Current Ph.D. Students  

  • Edgar Medina-Tovar  
  • Selcan Tuncay  
  • David Winski  
  • Mariana Gomez-Schiavon  
  • Anthony Burnetti  
  • Sargis Karapetyan  
Postdocs Mentored

  • Anne M. Augustus (August 01, 2013 - present)  
  • Heungwon Park (September 01, 2010 - present)