Nicolas Buchler, Assistant Professor of Physics and Biology
Office Location: 2353A CIEMAS
Office Phone: (919) 699-8209
Email Address: nicolas.buchler@duke.edu
Web Page: http://buchler.phy.duke.edu
Specialties:
Biological physics
Nonlinear dynamics and complex systems
Chemical Physics
Education:
PhD, University of Michigan, 2001
BS, University of California, San Diego, 1995
Representative Publications (More Publications)
- N. E. Buchler and F. R. Cross, Protein sequestration generates a flexible ultrasensitive response in a genetic network., Mol Syst Biol, vol. 5 (2009), pp. 272 [abs].
- N. E. Buchler and M. Louis, Molecular titration and ultrasensitivity in regulatory networks., J Mol Biol, vol. 384 no. 5 (2008), pp. 1106-19 [abs].
- G. Fritz and N. E. Buchler and T. Hwa and U. Gerland, Designing sequential transcription logic: a simple genetic circuit for conditional memory., Syst Synth Biol, vol. 1 no. 2 (April, 2007), pp. 89-98 [abs].
- N. E. Buchler and U. Gerland and T. Hwa, Nonlinear protein degradation and the function of genetic circuits., Proc Natl Acad Sci U S A, vol. 102 no. 27 (2005), pp. 9559-64 [abs].
- N. E. Buchler and U. Gerland and T. Hwa, On schemes of combinatorial transcription logic., Proc Natl Acad Sci U S A, vol. 100 no. 9 (2003), pp. 5136-41 [abs].
Highlight:
Bistable and oscillatory dynamics in regulatory networks are essential for patterning, cell proliferation, and cell differentiation in biological systems. My lab takes an interdisciplinary approach (theory and experiment; physics and biology; synthetic and systems biology) to understand the diverse molecular and evolutionary mechanisms by which thresholds, combinatorial control, bistability, and oscillation have evolved in biological systems.
- Current Ph.D. Students
- Selcan Tuncay
- David Winski
- Mariana Gomez-Schiavon
- Anthony Burnetti
- Sargis Karapetyan
- Charlie Cooper