Nicolas Buchler, Assistant Professor of Biology and Physics  

Nicolas Buchler

Office Location: 2353A CIEMAS
Office Phone: (919) 699-8209
Email Address:
Web Page:

Biological physics
Nonlinear dynamics and complex systems
Chemical Physics

PhD, University of Michigan, 2001
BS, University of California, San Diego, 1995

Representative Publications   (More Publications)

  1. N. E. Buchler and F. R. Cross, Protein sequestration generates a flexible ultrasensitive response in a genetic network., Mol Syst Biol, vol. 5 (2009), pp. 272  [abs].
  2. N. E. Buchler and M. Louis, Molecular titration and ultrasensitivity in regulatory networks., J Mol Biol, vol. 384 no. 5 (2008), pp. 1106-19  [abs].
  3. G. Fritz and N. E. Buchler and T. Hwa and U. Gerland, Designing sequential transcription logic: a simple genetic circuit for conditional memory., Syst Synth Biol, vol. 1 no. 2 (April, 2007), pp. 89-98  [abs].
  4. N. E. Buchler and U. Gerland and T. Hwa, Nonlinear protein degradation and the function of genetic circuits., Proc Natl Acad Sci U S A, vol. 102 no. 27 (2005), pp. 9559-64  [abs].
  5. N. E. Buchler and U. Gerland and T. Hwa, On schemes of combinatorial transcription logic., Proc Natl Acad Sci U S A, vol. 100 no. 9 (2003), pp. 5136-41  [abs].

Bistable and oscillatory dynamics in regulatory networks are essential for patterning, cell proliferation, and cell differentiation in biological systems. My lab takes an interdisciplinary approach (theory and experiment; physics and biology; synthetic and systems biology) to understand the diverse molecular and evolutionary mechanisms by which thresholds, combinatorial control, bistability, and oscillation have evolved in biological systems.

Current Ph.D. Students  

  • Edgar Medina-Tovar  
  • Selcan Tuncay  
  • David Winski  
  • Mariana Gomez-Schiavon  
  • Anthony Burnetti  
  • Sargis Karapetyan  
  • Charlie Cooper  
Postdocs Mentored

  • Anne M. Augustus (August 01, 2013 - present)