Publications [#228186] of Nicolas Buchler

Papers Published
  1. Archambault, V; Buchler, NE; Wilmes, GM; Jacobson, MD; Cross, FR, Two-faced cyclins with eyes on the targets, Cell Cycle, vol. 4 no. 1 (2005), pp. 125-130 .

    We recently reported that the 'hydrophobic patch' (HP) of the Saccharomyces cerevisiae S-phase cyclin Clb5 facilitates its interaction with Orco (via its Cy or RXL motif), providing a mechanism that helps prevent rereplication from individual origins. This is the first finding of a biological function for an interaction between a cyclin and a cyclin-binding motif (Cy or RXL motif) in a target protein in Saccharomyces cerevisiae. It is also the first such example involving a B-type cyclin in any organism. Yet, some of our observations as well as work from other groups suggest that HP-RXL interactions are functionally important for cyclin-Cdk signaling to other targets. The evolutionary conservation of the HP motif suggests that it allows cyclins to carry out important and specialized functions. ©2005 Landes Bioscience.