Bastiaan Driehuys, Professor of Radiology and Associate Research Professor of Physics and Associate Professor of Biomedical Engineering
Office Location: 161-B Bryan Research, 311 Research Drive, Durham, NC 27710
Office Phone: (919) 684-7786
Email Address: email@example.com
Web Page: http://faculty.duhs.duke.edu/faculty/info?pid=12292
Ph.D., Princeton University, 1995
- B Driehuys, S Martinez-Jimenez, ZI Cleveland, GM Metz, DM Beaver, JC Nouls, SS Kaushik, R Firszt, C Willis, KT Kelly, J Wolber, M Kraft and HP McAdams, Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients.,
Radiology, vol. 262 no. 1
pp. 279-289 , [doi] [abs].
- HE Möller, ZI Cleveland and B Driehuys, Relaxation of hyperpolarized 129Xe in a deflating polymer bag.,
J Magn Reson, vol. 212 no. 1
pp. 109-115 , [doi] [abs].
- AC Thomas, JC Nouls, B Driehuys, JW Voltz, B Fubara, J Foley, JA Bradbury and DC Zeldin, Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury.,
Am J Respir Cell Mol Biol, vol. 44 no. 5
pp. 648-654 , [doi] [abs].
- J Nouls, M Fanarjian, L Hedlund and B Driehuys, A Constant-Volume Ventilator and Gas Recapture System for Hyperpolarized Gas MRI of Mouse and Rat Lungs.,
Concepts Magn Reson Part B Magn Reson Eng, vol. 39B no. 2
pp. 78-88 , [doi] .
- W Zheng, ZI Cleveland, HE Möller and B Driehuys, Gradient-induced longitudinal relaxation of hyperpolarized noble gases in the fringe fields of superconducting magnets used for magnetic resonance.,
J Magn Reson, vol. 208 no. 2
pp. 284-290 , [doi] [abs].
- SS Kaushik, ZI Cleveland, GP Cofer, G Metz, D Beaver, J Nouls, M Kraft, W Auffermann, J Wolber, HP McAdams, B Driehuys, Diffusion-weighted hyperpolarized (129)Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease.,
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
(December, 2010) [doi] [abs].
- NN Mistry, A Thomas, SS Kaushik, GA Johnson and B Driehuys, Quantitative analysis of hyperpolarized 3He ventilation changes in mice challenged with methacholine.,
Magn Reson Med, vol. 63 no. 3
pp. 658-666 , [doi] [abs].
- RT Branca, ZI Cleveland, B Fubara, CS Kumar, RR Maronpot, C Leuschner, WS Warren and B Driehuys, Molecular MRI for sensitive and specific detection of lung metastases.,
Proc Natl Acad Sci U S A, vol. 107 no. 8
pp. 3693-3697 , [doi] [abs].
- ZI Cleveland, GP Cofer, G Metz, D Beaver, J Nouls, SS Kaushik, M Kraft, J Wolber, KT Kelly, HP McAdams and B Driehuys, Hyperpolarized Xe MR imaging of alveolar gas uptake in humans.,
PLoS One, vol. 5 no. 8
pp. e12192 , [doi] [abs].
- ZI Cleveland, HE Möller, LW Hedlund and B Driehuys, Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes.,
J Phys Chem B, vol. 113 no. 37
pp. 12489-12499 , [doi] [abs].
- B Driehuys, HE Möller, ZI Cleveland, J Pollaro and LW Hedlund, Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe.,
Radiology, vol. 252 no. 2
pp. 386-393 , [doi] [abs].
- AC Thomas, EN Potts, BT Chen, DM Slipetz, WM Foster and B Driehuys, A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI.,
NMR Biomed, vol. 22 no. 5
pp. 502-515 , [doi] [abs].
- B Driehuys, HE Moeller, ZI Cleveland, J Pollaro and LW Hedlund, Pulmonary Perfusion and Xenon Gas Exchange in Rats: MR Imaging with Intravenous Injection of Hyperpolarized (129)Xe,
RADIOLOGY, vol. 252 no. 2
pp. 386-393 [Gateway.cgi], [doi] [abs].
- RH Brown, CG Irvin, GB Allen, SD Shapiro, WJ Martin, MR Kolb, DM Hyde, GF Nieman, DD Cody, M Ishii, SJ Kadlecek, B Driehuys, RR Rizi, AM Wu, WA Weber, DB Stout and ATS Small Animal Imaging Subcommittee, An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology.,
Proc Am Thorac Soc, vol. 5 no. 5
pp. 591-600 , [doi] .
- B Driehuys, J Pollaro and GP Cofer, In vivo MRI using real-time production of hyperpolarized 129Xe.,
Magn Reson Med, vol. 60 no. 1
pp. 14-20 , [doi] [abs].
- B Driehuys, J Nouls, A Badea, E Bucholz, K Ghaghada, A Petiet and LW Hedlund, Small animal imaging with magnetic resonance microscopy.,
ILAR J, vol. 49 no. 1
pp. 35-53 , [doi] [abs].
- B Driehuys, J Walker, J Pollaro, GP Cofer, N Mistry, D Schwartz and GA Johnson, 3He MRI in mouse models of asthma.,
Magn Reson Med, vol. 58 no. 5
pp. 893-900 , [doi] [abs].
- B Driehuys and LW Hedlund, Imaging techniques for small animal models of pulmonary disease: MR microscopy.,
Toxicol Pathol, vol. 35 no. 1
pp. 49-58 , [doi] [abs].
- B Driehuys, GP Cofer, J Pollaro, JB Mackel, LW Hedlund and GA Johnson, Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI.,
Proc Natl Acad Sci U S A, vol. 103 no. 48
pp. 18278-18283 , [doi] [abs].
- ZZ Spector, K Emami, MC Fischer, J Zhu, M Ishii, V Vahdat, J Yu, S Kadlecek, B Driehuys, DA Lipson, W Gefter, J Shrager and RR Rizi, Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging.,
Magn Reson Med, vol. 53 no. 6
pp. 1341-1346 , [doi] [abs].
- ZZ Spector, K Emami, MC Fischer, J Zhu, M Ishii, J Yu, S Kadlecek, B Driehuys, RA Panettieri, DA Lipson, W Gefter, J Shrager and RR Rizi, A small animal model of regional alveolar ventilation using HP 3He MRI1.,
Acad Radiol, vol. 11 no. 10
pp. 1171-1179 , [doi] [abs].
- S Månsson, J Wolber, B Driehuys, P Wollmer and K Golman, Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe.,
Magn Reson Med, vol. 50 no. 6
pp. 1170-1179 , [doi] [abs].
- E Babcock, I Nelson, S Kadlecek, B Driehuys, LW Anderson, FW Hersman and TG Walker, Hybrid spin-exchange optical pumping of 3He.,
Phys Rev Lett, vol. 91 no. 12
pp. 123003 , [doi] [abs].
- K Ruppert, JR Brookeman, KD Hagspiel, B Driehuys and JP Mugler, NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold.,
NMR Biomed, vol. 13 no. 4
pp. 220-228  [abs].
- XJ Chen, HE Möller, MS Chawla, GP Cofer, B Driehuys, LW Hedlund and GA Johnson, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient.,
Magn Reson Med, vol. 42 no. 4
pp. 721-728  [abs].
- XJ Chen, HE Möller, MS Chawla, GP Cofer, B Driehuys, LW Hedlund, JR MacFall and GA Johnson, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2).,
Magn Reson Med, vol. 42 no. 4
pp. 729-737  [abs].
- A Stith, TK Hitchens, DP Hinton, SS Berr, B Driehuys, JR Brookeman and RG Bryant, Consequences of (129)Xe-(1)H cross relaxation in aqueous solutions.,
J Magn Reson, vol. 139 no. 2
pp. 225-231 , [doi] [abs].
- HE Möller, MS Chawla, XJ Chen, B Driehuys, LW Hedlund, CT Wheeler and GA Johnson, Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion.,
Magn Reson Med, vol. 41 no. 5
pp. 1058-1064  [abs].
- HE Möller, XJ Chen, MS Chawla, GP Cofer, B Driehuys, LW Hedlund, SA Suddarth and GA Johnson, Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases.,
Magn Reson Med, vol. 41 no. 4
pp. 800-808  [abs].
- HE Möller, XJ Chen, MS Chawla, B Driehuys, LW Hedlund and GA Johnson, Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases.,
J Magn Reson, vol. 135 no. 1
pp. 133-143 , [doi] [abs].
- GA Johnson, G Cates, XJ Chen, GP Cofer, B Driehuys, W Happer, LW Hedlund, B Saam, MD Shattuck and J Swartz, Dynamics of magnetization in hyperpolarized gas MRI of the lung.,
Magn Reson Med, vol. 38 no. 1
pp. 66-71  [abs].
- JP Mugler, B Driehuys, JR Brookeman, GD Cates, SS Berr, RG Bryant, TM Daniel, EE de Lange, JH Downs, CJ Erickson, W Happer, DP Hinton, NF Kassel, T Maier, CD Phillips, BT Saam, KL Sauer and ME Wagshul, MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results.,
Magn Reson Med, vol. 37 no. 6
pp. 809-815  [abs].
- JR MacFall, HC Charles, RD Black, H Middleton, JC Swartz, B Saam, B Driehuys, C Erickson, W Happer, GD Cates, GA Johnson and CE Ravin, Human lung air spaces: potential for MR imaging with hyperpolarized He-3.,
Radiology, vol. 200 no. 2
pp. 553-558 , [doi] [abs].
- RD Black, HL Middleton, GD Cates, GP Cofer, B Driehuys, W Happer, LW Hedlund, GA Johnson, MD Shattuck and JC Swartz, In vivo He-3 MR images of guinea pig lungs.,
Radiology, vol. 199 no. 3
pp. 867-870 , [doi] [abs].
- B Driehuys, GD Cates and W Happer, Surface relaxation mechanisms of laser-polarized 129Xe.,
Phys Rev Lett, vol. 74 no. 24
pp. 4943-4946 , [doi] .
- MS Albert, GD Cates, B Driehuys, W Happer, B Saam, CS Springer and A Wishnia, Biological magnetic resonance imaging using laser-polarized 129Xe.,
Nature, vol. 370 no. 6486
pp. 199-201 , [doi] [abs].
- AS Barton, NR Newbury, GD Cates, B Driehuys, H Middleton and B Saam, Self-calibrating measurement of polarization-dependent frequency shifts from Rb-3He collisions.,
Phys Rev A, vol. 49 no. 4
pp. 2766-2770  .
- M Gatzke, GD Cates, B Driehuys, D Fox, W Happer and B Saam, Extraordinarily slow nuclear spin relaxation in frozen laser-polarized 129Xe.,
Phys Rev Lett, vol. 70 no. 5
pp. 690-693 , [doi] .
My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.