Bastiaan Driehuys, Associate Research Professor of Radiology and Physics  

Bastiaan Driehuys

Office Location: 161-B Bryan Research, 311 Research Drive, Durham, NC 27710
Office Phone: (919) 684-7786
Email Address: bastiaan.driehuys@duke.edu
Web Page: http://faculty.duhs.duke.edu/faculty/info?pid=12292

Education:
Ph.D., Princeton University, 1995

Representative Publications   (More Publications)

  1. Driehuys, B; Martinez-Jimenez, S; Cleveland, ZI; Metz, GM; Beaver, DM; Nouls, JC; Kaushik, SS; Firszt, R; Willis, C; Kelly, KT; Wolber, J; Kraft, M; McAdams, HP, Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients., Radiology, vol. 262 no. 1 (January, 2012), pp. 279-289 [22056683], [doi]  [abs].
  2. Möller, HE; Cleveland, ZI; Driehuys, B, Relaxation of hyperpolarized 129Xe in a deflating polymer bag., Journal of Magnetic Resonance, vol. 212 no. 1 (September, 2011), pp. 109-115 [21752680], [doi]  [abs].
  3. Thomas, AC; Nouls, JC; Driehuys, B; Voltz, JW; Fubara, B; Foley, J; Bradbury, JA; Zeldin, DC, Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury., American journal of respiratory cell and molecular biology, vol. 44 no. 5 (May, 2011), pp. 648-654 [20595465], [doi]  [abs].
  4. Nouls, J; Fanarjian, M; Hedlund, L; Driehuys, B, A Constant-Volume Ventilator and Gas Recapture System for Hyperpolarized Gas MRI of Mouse and Rat Lungs., Concepts in Magnetic Resonance Part B, vol. 39B no. 2 (April, 2011), pp. 78-88 [21625347], [doi] .
  5. Kaushik, SS; Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kraft, M; Auffermann, W; Wolber, J; McAdams, HP; Driehuys, B, Diffusion-weighted hyperpolarized (129)Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease., Magnetic Resonance in Medicine, vol. 65 no. 4 (December, 2010), pp. 1154-65 [21166014], [doi]  [abs].
  6. Zheng, W; Cleveland, ZI; Möller, HE; Driehuys, B, Gradient-induced longitudinal relaxation of hyperpolarized noble gases in the fringe fields of superconducting magnets used for magnetic resonance., Journal of Magnetic Resonance, vol. 208 no. 2 (February, 2011), pp. 284-290 [21134771], [doi]  [abs].
  7. SS Kaushik, ZI Cleveland, GP Cofer, G Metz, D Beaver, J Nouls, M Kraft, W Auffermann, J Wolber, HP McAdams, B Driehuys, Diffusion-weighted hyperpolarized (129)Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (December, 2010) [doi]  [abs].
  8. Mistry, NN; Thomas, A; Kaushik, SS; Johnson, GA; Driehuys, B, Quantitative analysis of hyperpolarized 3He ventilation changes in mice challenged with methacholine., Magnetic Resonance in Medicine, vol. 63 no. 3 (March, 2010), pp. 658-666 [20187176], [doi]  [abs].
  9. Branca, RT; Cleveland, ZI; Fubara, B; Kumar, CS; Maronpot, RR; Leuschner, C; Warren, WS; Driehuys, B, Molecular MRI for sensitive and specific detection of lung metastases., Proceedings of the National Academy of Sciences of USA, vol. 107 no. 8 (February, 2010), pp. 3693-3697 [20142483], [doi]  [abs].
  10. Cleveland, ZI; Cofer, GP; Metz, G; Beaver, D; Nouls, J; Kaushik, SS; Kraft, M; Wolber, J; Kelly, KT; McAdams, HP; Driehuys, B, Hyperpolarized Xe MR imaging of alveolar gas uptake in humans., PloS one, vol. 5 no. 8 (August, 2010), pp. e12192 [20808950], [doi]  [abs].
  11. Cleveland, ZI; Möller, HE; Hedlund, LW; Driehuys, B, Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes., The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces and Biophysical, vol. 113 no. 37 (September, 2009), pp. 12489-12499 [19702286], [doi]  [abs].
  12. Driehuys, B; Möller, HE; Cleveland, ZI; Pollaro, J; Hedlund, LW, Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe., Radiology, vol. 252 no. 2 (August, 2009), pp. 386-393 [19703880], [doi]  [abs].
  13. Thomas, AC; Potts, EN; Chen, BT; Slipetz, DM; Foster, WM; Driehuys, B, A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI., Nmr in Biomedicine, vol. 22 no. 5 (June, 2009), pp. 502-515 [19204996], [doi]  [abs].
  14. Driehuys, B; Moeller, HE; Cleveland, ZI; Pollaro, J; Hedlund, LW, Pulmonary Perfusion and Xenon Gas Exchange in Rats: MR Imaging with Intravenous Injection of Hyperpolarized (129)Xe, Radiology, vol. 252 no. 2 (August, 2009), pp. 386-393 [Gateway.cgi], [doi]  [abs].
  15. Brown, RH; Irvin, CG; Allen, GB; Shapiro, SD; Martin, WJ; Kolb, MR; Hyde, DM; Nieman, GF; Cody, DD; Ishii, M; Kadlecek, SJ; Driehuys, B; Rizi, RR; Wu, AM; Weber, WA; Stout, DB; ATS Small Animal Imaging Subcommittee, , An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology., Proceedings of the American Thoracic Society, vol. 5 no. 5 (July, 2008), pp. 591-600 [18625751], [doi] .
  16. Driehuys, B; Pollaro, J; Cofer, GP, In vivo MRI using real-time production of hyperpolarized 129Xe., Magnetic Resonance in Medicine, vol. 60 no. 1 (July, 2008), pp. 14-20 [18581406], [doi]  [abs].
  17. Driehuys, B; Nouls, J; Badea, A; Bucholz, E; Ghaghada, K; Petiet, A; Hedlund, LW, Small animal imaging with magnetic resonance microscopy., ILAR Journal, vol. 49 no. 1 (2008), pp. 35-53 [18172332], [doi]  [abs].
  18. Driehuys, B; Walker, J; Pollaro, J; Cofer, GP; Mistry, N; Schwartz, D; Johnson, GA, 3He MRI in mouse models of asthma., Magnetic Resonance in Medicine, vol. 58 no. 5 (November, 2007), pp. 893-900 [17969115], [doi]  [abs].
  19. Driehuys, B; Hedlund, LW, Imaging techniques for small animal models of pulmonary disease: MR microscopy., Toxicologic Pathology (Sage), vol. 35 no. 1 (January, 2007), pp. 49-58 [17325972], [doi]  [abs].
  20. Driehuys, B; Cofer, GP; Pollaro, J; Mackel, JB; Hedlund, LW; Johnson, GA, Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI., Proceedings of the National Academy of Sciences of USA, vol. 103 no. 48 (November, 2006), pp. 18278-18283 [17101964], [doi]  [abs].
  21. Driehuys, B, Chemistry: Toward molecular imaging with xenon MRI, Science, vol. 314 no. 5798 (October, 2006), pp. 432-433 [17053138], [doi] .
  22. Spector, ZZ; Emami, K; Fischer, MC; Zhu, J; Ishii, M; Vahdat, V; Yu, J; Kadlecek, S; Driehuys, B; Lipson, DA; Gefter, W; Shrager, J; Rizi, RR, Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging., Magnetic Resonance in Medicine, vol. 53 no. 6 (June, 2005), pp. 1341-1346 [15906306], [doi]  [abs].
  23. Spector, ZZ; Emami, K; Fischer, MC; Zhu, J; Ishii, M; Yu, J; Kadlecek, S; Driehuys, B; Panettieri, RA; Lipson, DA; Gefter, W; Shrager, J; Rizi, RR, A small animal model of regional alveolar ventilation using HP 3He MRI1., Academic Radiology, vol. 11 no. 10 (October, 2004), pp. 1171-1179 [15530811], [doi]  [abs].
  24. Månsson, S; Wolber, J; Driehuys, B; Wollmer, P; Golman, K, Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe., Magnetic Resonance in Medicine, vol. 50 no. 6 (December, 2003), pp. 1170-1179 [14648564], [doi]  [abs].
  25. Babcock, E; Nelson, I; Kadlecek, S; Driehuys, B; Anderson, LW; Hersman, FW; Walker, TG, Hybrid spin-exchange optical pumping of 3He., Physical Review Letters, vol. 91 no. 12 (September, 2003), pp. 123003 [14525358], [doi]  [abs].
  26. Ruppert, K; Brookeman, JR; Hagspiel, KD; Driehuys, B; Mugler, JP, NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold., Nmr in Biomedicine, vol. 13 no. 4 (June, 2000), pp. 220-228 [10867700]  [abs].
  27. Chen, XJ; Möller, HE; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; Johnson, GA, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient., Magnetic Resonance in Medicine, vol. 42 no. 4 (October, 1999), pp. 721-728 [10502761]  [abs].
  28. Chen, XJ; Möller, HE; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; MacFall, JR; Johnson, GA, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2)., Magnetic Resonance in Medicine, vol. 42 no. 4 (October, 1999), pp. 729-737 [10502762]  [abs].
  29. Stith, A; Hitchens, TK; Hinton, DP; Berr, SS; Driehuys, B; Brookeman, JR; Bryant, RG, Consequences of (129)Xe-(1)H cross relaxation in aqueous solutions., Journal of Magnetic Resonance, vol. 139 no. 2 (August, 1999), pp. 225-231 [10423359], [doi]  [abs].
  30. Möller, HE; Chawla, MS; Chen, XJ; Driehuys, B; Hedlund, LW; Wheeler, CT; Johnson, GA, Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion., Magnetic Resonance in Medicine, vol. 41 no. 5 (May, 1999), pp. 1058-1064 [10332890]  [abs].
  31. Möller, HE; Chen, XJ; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; Suddarth, SA; Johnson, GA, Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases., Magnetic Resonance in Medicine, vol. 41 no. 4 (April, 1999), pp. 800-808 [10332857]  [abs].
  32. Möller, HE; Chen, XJ; Chawla, MS; Driehuys, B; Hedlund, LW; Johnson, GA, Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases., Journal of Magnetic Resonance, vol. 135 no. 1 (November, 1998), pp. 133-143 [9799687], [doi]  [abs].
  33. Johnson, GA; Cates, G; Chen, XJ; Cofer, GP; Driehuys, B; Happer, W; Hedlund, LW; Saam, B; Shattuck, MD; Swartz, J, Dynamics of magnetization in hyperpolarized gas MRI of the lung., Magnetic Resonance in Medicine, vol. 38 no. 1 (July, 1997), pp. 66-71 [9211381]  [abs].
  34. Mugler, JP; Driehuys, B; Brookeman, JR; Cates, GD; Berr, SS; Bryant, RG; Daniel, TM; de Lange, EE; Downs, JH; Erickson, CJ; Happer, W; Hinton, DP; Kassel, NF; Maier, T; Phillips, CD; Saam, BT; Sauer, KL; Wagshul, ME, MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results., Magnetic Resonance in Medicine, vol. 37 no. 6 (June, 1997), pp. 809-815 [9178229]  [abs].
  35. MacFall, JR; Charles, HC; Black, RD; Middleton, H; Swartz, JC; Saam, B; Driehuys, B; Erickson, C; Happer, W; Cates, GD; Johnson, GA; Ravin, CE, Human lung air spaces: potential for MR imaging with hyperpolarized He-3., Radiology, vol. 200 no. 2 (August, 1996), pp. 553-558 [8685356], [doi]  [abs].
  36. Black, RD; Middleton, HL; Cates, GD; Cofer, GP; Driehuys, B; Happer, W; Hedlund, LW; Johnson, GA; Shattuck, MD; Swartz, JC, In vivo He-3 MR images of guinea pig lungs., Radiology, vol. 199 no. 3 (June, 1996), pp. 867-870 [8638019], [doi]  [abs].
  37. Driehuys, B; Cates, GD; Happer, W, Surface relaxation mechanisms of laser-polarized 129Xe., Physical Review Letters, vol. 74 no. 24 (June, 1995), pp. 4943-4946 [10058638], [doi] .
  38. Albert, MS; Cates, GD; Driehuys, B; Happer, W; Saam, B; Springer, CS; Wishnia, A, Biological magnetic resonance imaging using laser-polarized 129Xe., Nature, vol. 370 no. 6486 (July, 1994), pp. 199-201 [8028666], [doi]  [abs].
  39. Barton, AS; Newbury, NR; Cates, GD; Driehuys, B; Middleton, H; Saam, B, Self-calibrating measurement of polarization-dependent frequency shifts from Rb-3He collisions., Physical Review A - Atomic, Molecular, and Optical Physics, vol. 49 no. 4 (April, 1994), pp. 2766-2770 [9910557] .
  40. Gatzke, M; Cates, GD; Driehuys, B; Fox, D; Happer, W; Saam, B, Extraordinarily slow nuclear spin relaxation in frozen laser-polarized 129Xe., Physical Review Letters, vol. 70 no. 5 (February, 1993), pp. 690-693 [10054178], [doi] .

Highlight:
My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.