Bastiaan Driehuys, Professor of Radiology and Associate Research Professor of Physics and Associate Professor of Biomedical Engineering  

Bastiaan Driehuys

Office Location: 161-B Bryan Research, 311 Research Drive, Durham, NC 27710
Office Phone: (919) 684-7786
Email Address: bastiaan.driehuys@duke.edu
Web Page: http://faculty.duhs.duke.edu/faculty/info?pid=12292

Education:
Ph.D., Princeton University, 1995

Representative Publications   (More Publications)

  1. B Driehuys, S Martinez-Jimenez, ZI Cleveland, GM Metz, DM Beaver, JC Nouls, SS Kaushik, R Firszt, C Willis, KT Kelly, J Wolber, M Kraft and HP McAdams, Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients., Radiology, vol. 262 no. 1 (January, 2012), pp. 279-289 [22056683], [doi]  [abs].
  2. HE Möller, ZI Cleveland and B Driehuys, Relaxation of hyperpolarized 129Xe in a deflating polymer bag., J Magn Reson, vol. 212 no. 1 (September, 2011), pp. 109-115 [21752680], [doi]  [abs].
  3. AC Thomas, JC Nouls, B Driehuys, JW Voltz, B Fubara, J Foley, JA Bradbury and DC Zeldin, Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury., Am J Respir Cell Mol Biol, vol. 44 no. 5 (May, 2011), pp. 648-654 [20595465], [doi]  [abs].
  4. J Nouls, M Fanarjian, L Hedlund and B Driehuys, A Constant-Volume Ventilator and Gas Recapture System for Hyperpolarized Gas MRI of Mouse and Rat Lungs., Concepts Magn Reson Part B Magn Reson Eng, vol. 39B no. 2 (April, 2011), pp. 78-88 [21625347], [doi] .
  5. W Zheng, ZI Cleveland, HE Möller and B Driehuys, Gradient-induced longitudinal relaxation of hyperpolarized noble gases in the fringe fields of superconducting magnets used for magnetic resonance., J Magn Reson, vol. 208 no. 2 (February, 2011), pp. 284-290 [21134771], [doi]  [abs].
  6. SS Kaushik, ZI Cleveland, GP Cofer, G Metz, D Beaver, J Nouls, M Kraft, W Auffermann, J Wolber, HP McAdams, B Driehuys, Diffusion-weighted hyperpolarized (129)Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine (December, 2010) [doi]  [abs].
  7. NN Mistry, A Thomas, SS Kaushik, GA Johnson and B Driehuys, Quantitative analysis of hyperpolarized 3He ventilation changes in mice challenged with methacholine., Magn Reson Med, vol. 63 no. 3 (March, 2010), pp. 658-666 [20187176], [doi]  [abs].
  8. RT Branca, ZI Cleveland, B Fubara, CS Kumar, RR Maronpot, C Leuschner, WS Warren and B Driehuys, Molecular MRI for sensitive and specific detection of lung metastases., Proc Natl Acad Sci U S A, vol. 107 no. 8 (February, 2010), pp. 3693-3697 [20142483], [doi]  [abs].
  9. ZI Cleveland, GP Cofer, G Metz, D Beaver, J Nouls, SS Kaushik, M Kraft, J Wolber, KT Kelly, HP McAdams and B Driehuys, Hyperpolarized Xe MR imaging of alveolar gas uptake in humans., PLoS One, vol. 5 no. 8 (2010), pp. e12192 [20808950], [doi]  [abs].
  10. ZI Cleveland, HE Möller, LW Hedlund and B Driehuys, Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes., J Phys Chem B, vol. 113 no. 37 (September, 2009), pp. 12489-12499 [19702286], [doi]  [abs].
  11. B Driehuys, HE Möller, ZI Cleveland, J Pollaro and LW Hedlund, Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe., Radiology, vol. 252 no. 2 (August, 2009), pp. 386-393 [19703880], [doi]  [abs].
  12. AC Thomas, EN Potts, BT Chen, DM Slipetz, WM Foster and B Driehuys, A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI., NMR Biomed, vol. 22 no. 5 (June, 2009), pp. 502-515 [19204996], [doi]  [abs].
  13. B Driehuys, HE Moeller, ZI Cleveland, J Pollaro and LW Hedlund, Pulmonary Perfusion and Xenon Gas Exchange in Rats: MR Imaging with Intravenous Injection of Hyperpolarized (129)Xe, RADIOLOGY, vol. 252 no. 2 (August, 2009), pp. 386-393 [Gateway.cgi], [doi]  [abs].
  14. RH Brown, CG Irvin, GB Allen, SD Shapiro, WJ Martin, MR Kolb, DM Hyde, GF Nieman, DD Cody, M Ishii, SJ Kadlecek, B Driehuys, RR Rizi, AM Wu, WA Weber, DB Stout and ATS Small Animal Imaging Subcommittee, An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology., Proc Am Thorac Soc, vol. 5 no. 5 (July, 2008), pp. 591-600 [18625751], [doi] .
  15. B Driehuys, J Pollaro and GP Cofer, In vivo MRI using real-time production of hyperpolarized 129Xe., Magn Reson Med, vol. 60 no. 1 (July, 2008), pp. 14-20 [18581406], [doi]  [abs].
  16. B Driehuys, J Nouls, A Badea, E Bucholz, K Ghaghada, A Petiet and LW Hedlund, Small animal imaging with magnetic resonance microscopy., ILAR J, vol. 49 no. 1 (2008), pp. 35-53 [18172332], [doi]  [abs].
  17. B Driehuys, J Walker, J Pollaro, GP Cofer, N Mistry, D Schwartz and GA Johnson, 3He MRI in mouse models of asthma., Magn Reson Med, vol. 58 no. 5 (November, 2007), pp. 893-900 [17969115], [doi]  [abs].
  18. B Driehuys and LW Hedlund, Imaging techniques for small animal models of pulmonary disease: MR microscopy., Toxicol Pathol, vol. 35 no. 1 (January, 2007), pp. 49-58 [17325972], [doi]  [abs].
  19. B Driehuys, GP Cofer, J Pollaro, JB Mackel, LW Hedlund and GA Johnson, Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI., Proc Natl Acad Sci U S A, vol. 103 no. 48 (November, 2006), pp. 18278-18283 [17101964], [doi]  [abs].
  20. ZZ Spector, K Emami, MC Fischer, J Zhu, M Ishii, V Vahdat, J Yu, S Kadlecek, B Driehuys, DA Lipson, W Gefter, J Shrager and RR Rizi, Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging., Magn Reson Med, vol. 53 no. 6 (June, 2005), pp. 1341-1346 [15906306], [doi]  [abs].
  21. ZZ Spector, K Emami, MC Fischer, J Zhu, M Ishii, J Yu, S Kadlecek, B Driehuys, RA Panettieri, DA Lipson, W Gefter, J Shrager and RR Rizi, A small animal model of regional alveolar ventilation using HP 3He MRI1., Acad Radiol, vol. 11 no. 10 (October, 2004), pp. 1171-1179 [15530811], [doi]  [abs].
  22. S Månsson, J Wolber, B Driehuys, P Wollmer and K Golman, Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe., Magn Reson Med, vol. 50 no. 6 (December, 2003), pp. 1170-1179 [14648564], [doi]  [abs].
  23. E Babcock, I Nelson, S Kadlecek, B Driehuys, LW Anderson, FW Hersman and TG Walker, Hybrid spin-exchange optical pumping of 3He., Phys Rev Lett, vol. 91 no. 12 (September, 2003), pp. 123003 [14525358], [doi]  [abs].
  24. K Ruppert, JR Brookeman, KD Hagspiel, B Driehuys and JP Mugler, NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold., NMR Biomed, vol. 13 no. 4 (June, 2000), pp. 220-228 [10867700]  [abs].
  25. XJ Chen, HE Möller, MS Chawla, GP Cofer, B Driehuys, LW Hedlund and GA Johnson, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient., Magn Reson Med, vol. 42 no. 4 (October, 1999), pp. 721-728 [10502761]  [abs].
  26. XJ Chen, HE Möller, MS Chawla, GP Cofer, B Driehuys, LW Hedlund, JR MacFall and GA Johnson, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2)., Magn Reson Med, vol. 42 no. 4 (October, 1999), pp. 729-737 [10502762]  [abs].
  27. A Stith, TK Hitchens, DP Hinton, SS Berr, B Driehuys, JR Brookeman and RG Bryant, Consequences of (129)Xe-(1)H cross relaxation in aqueous solutions., J Magn Reson, vol. 139 no. 2 (August, 1999), pp. 225-231 [10423359], [doi]  [abs].
  28. HE Möller, MS Chawla, XJ Chen, B Driehuys, LW Hedlund, CT Wheeler and GA Johnson, Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion., Magn Reson Med, vol. 41 no. 5 (May, 1999), pp. 1058-1064 [10332890]  [abs].
  29. HE Möller, XJ Chen, MS Chawla, GP Cofer, B Driehuys, LW Hedlund, SA Suddarth and GA Johnson, Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases., Magn Reson Med, vol. 41 no. 4 (April, 1999), pp. 800-808 [10332857]  [abs].
  30. HE Möller, XJ Chen, MS Chawla, B Driehuys, LW Hedlund and GA Johnson, Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases., J Magn Reson, vol. 135 no. 1 (November, 1998), pp. 133-143 [9799687], [doi]  [abs].
  31. GA Johnson, G Cates, XJ Chen, GP Cofer, B Driehuys, W Happer, LW Hedlund, B Saam, MD Shattuck and J Swartz, Dynamics of magnetization in hyperpolarized gas MRI of the lung., Magn Reson Med, vol. 38 no. 1 (July, 1997), pp. 66-71 [9211381]  [abs].
  32. JP Mugler, B Driehuys, JR Brookeman, GD Cates, SS Berr, RG Bryant, TM Daniel, EE de Lange, JH Downs, CJ Erickson, W Happer, DP Hinton, NF Kassel, T Maier, CD Phillips, BT Saam, KL Sauer and ME Wagshul, MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results., Magn Reson Med, vol. 37 no. 6 (June, 1997), pp. 809-815 [9178229]  [abs].
  33. JR MacFall, HC Charles, RD Black, H Middleton, JC Swartz, B Saam, B Driehuys, C Erickson, W Happer, GD Cates, GA Johnson and CE Ravin, Human lung air spaces: potential for MR imaging with hyperpolarized He-3., Radiology, vol. 200 no. 2 (August, 1996), pp. 553-558 [8685356], [doi]  [abs].
  34. RD Black, HL Middleton, GD Cates, GP Cofer, B Driehuys, W Happer, LW Hedlund, GA Johnson, MD Shattuck and JC Swartz, In vivo He-3 MR images of guinea pig lungs., Radiology, vol. 199 no. 3 (June, 1996), pp. 867-870 [8638019], [doi]  [abs].
  35. B Driehuys, GD Cates and W Happer, Surface relaxation mechanisms of laser-polarized 129Xe., Phys Rev Lett, vol. 74 no. 24 (June, 1995), pp. 4943-4946 [10058638], [doi] .
  36. MS Albert, GD Cates, B Driehuys, W Happer, B Saam, CS Springer and A Wishnia, Biological magnetic resonance imaging using laser-polarized 129Xe., Nature, vol. 370 no. 6486 (July, 1994), pp. 199-201 [8028666], [doi]  [abs].
  37. AS Barton, NR Newbury, GD Cates, B Driehuys, H Middleton and B Saam, Self-calibrating measurement of polarization-dependent frequency shifts from Rb-3He collisions., Phys Rev A, vol. 49 no. 4 (April, 1994), pp. 2766-2770 [9910557] .
  38. M Gatzke, GD Cates, B Driehuys, D Fox, W Happer and B Saam, Extraordinarily slow nuclear spin relaxation in frozen laser-polarized 129Xe., Phys Rev Lett, vol. 70 no. 5 (February, 1993), pp. 690-693 [10054178], [doi] .

Highlight:
My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.