G. Allan Johnson, Charles E. Putman University Professor of Radiology and Professor of Physics and Member of Duke Cancer Institute  

G. Allan Johnson

Office Location: 141D Bryan Neuroscience Bldg, Research Drive, Durham, NC 27710
Office Phone: (919) 684-7754
Email Address: gjohnson@duke.edu
Web Page: http://www.civm.duhs.duke.edu/

Specialties:
Medical Imaging

Education:
Ph.D., Duke University, 1974

Research Categories: Medical Physics

Research Description: Dr. Johnson is the Charles E. Putman University Professor of Radiology, Physics, and Biomedical Engineering and Director of the Duke Center for In Vivo Microscopy (CIVM). The CIVM is an NIH NCRR/NIBIB national Biomedical Technology Resource Center with a mission to develop novel technologies for preclinical imaging (basic sciences) and apply the technologies to critical biomedical questions. Dr. Johnson was one of the first researchers to bring Paul Lauterbur's vision of magnetic resonance (MR) microscopy to practice as described in his paper, "Nuclear magnetic resonance imaging at microscopic resolution" (J Magn Reson 68:129-137, 1986). He is involved in both the engineering physics required to extend the resolution of MR imaging and in a broad range of applications in the basic sciences.

Areas of Interest:
magnetic resonance histology
magnetic resonance imaging
small animal imaging

Representative Publications   (More Publications)

  1. Calabrese, E; Johnson, GA, Diffusion tensor magnetic resonance histology reveals microstructural changes in the developing rat brain., NeuroImage, vol. 79 (October, 2013), pp. 329-339 [23648962], [doi]  [abs].
  2. Calabrese, E; Badea, A; Watson, C; Johnson, GA, A quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability., NeuroImage, vol. 71 (May, 2013), pp. 196-206 [23353030], [doi]  [abs].
  3. Calabrese, E; Johnson, GA; Watson, C, An ontology-based segmentation scheme for tracking postnatal changes in the developing rodent brain with MRI., NeuroImage, vol. 67 (February, 2013), pp. 375-384 [23246176], [doi]  [abs].
  4. Badea, CT; Hedlund, LW; Johnson, GA, A LabVIEW Platform for Preclinical Imaging Using Digital Subtraction Angiography and Micro-CT., Journal of Medical Engineering, vol. 2013 no. 581617 (January, 2013), pp. 581617 [repository], [doi]  [abs].
  5. Perperidis, D; Bucholz, E; Johnson, GA; Constantinides, C, Morphological studies of the murine heart based on probabilistic and statistical atlases., Computerized Medical Imaging and Graphics, vol. 36 no. 2 (March, 2012), pp. 119-129 [21820867], [doi]  [abs].
  6. Liu, C; Li, W; Wu, B; Jiang, Y; Johnson, GA, 3D fiber tractography with susceptibility tensor imaging., NeuroImage, vol. 59 no. 2 (January, 2012), pp. 1290-1298 [21867759], [doi]  [abs].
  7. Badea, A; Johnson, GA, Magnetic resonance microscopy., in Studies in Health Technology and Informatics, Analytical Cellular Pathology, vol. 35 no. 4 (2012), pp. 205-227, IOS Press Ebooks [22142643], [doi]  [abs].
  8. Antonsen, BT; Jiang, Y; Veraart, J; Qu, H; Nguyen, HP; Sijbers, J; Hörsten, SV; Johnson, GA; Leergaard, TB, Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats, Brain Structure and Function, vol. 218 no. 3 (2012), pp. 1-12 [doi]  [abs].
  9. Jiang, Y; Johnson, GA, Microscopic diffusion tensor atlas of the mouse brain., NeuroImage, vol. 56 no. 3 (June, 2011), pp. 1235-1243 [21419226], [doi]  [abs].
  10. Liu, C; Li, W; Johnson, GA; Wu, B, High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility., NeuroImage, vol. 56 no. 3 (June, 2011), pp. 930-938 [21320606], [doi]  [abs].
  11. Bowden, DM; Johnson, GA; Zaborsky, L; Green, WD; Moore, E; Badea, A; Dubach, MF; Bookstein, FL, A symmetrical Waxholm canonical mouse brain for NeuroMaps., Journal of Neuroscience Methods, vol. 195 no. 2 (February, 2011), pp. 170-175 [21163300], [doi]  [abs].
  12. Hawrylycz, M; Baldock, RA; Burger, A; Hashikawa, T; Johnson, GA; Martone, M; Ng, L; Lau, C; Larson, SD; Nissanov, J; Puelles, L; Ruffins, S; Verbeek, F; Zaslavsky, I; Boline, J, Digital atlasing and standardization in the mouse brain., PLoS computational biology, vol. 7 no. 2 (February, 2011), pp. e1001065 [21304938], [doi] .
  13. Pandit, P; Qi, Y; King, KF; Johnson, GA, Reduction of artifacts in T2 -weighted PROPELLER in high-field preclinical imaging., Magnetic Resonance in Medicine, vol. 65 no. 2 (February, 2011), pp. 538-543 [20928875], [doi]  [abs].
  14. Bucholz, E; Ghaghada, K; Qi, Y; Mukundan, S; Rockman, HA; Johnson, GA, Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA., Magnetic Resonance in Medicine, vol. 63 no. 4 (April, 2010), pp. 979-987 [20373399], [doi]  [abs].
  15. Badea, A; Johnson, GA; Jankowsky, JL, Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease., NeuroImage, vol. 50 no. 2 (April, 2010), pp. 416-427 [20035883], [doi]  [abs].
  16. Jiang, Y; Johnson, GA, Microscopic diffusion tensor imaging of the mouse brain., NeuroImage, vol. 50 no. 2 (April, 2010), pp. 465-471 [20034583], [doi]  [abs].
  17. Badea, A; Johnson, GA; Williams, RW, Genetic dissection of the mouse CNS using magnetic resonance microscopy., Current Opinion in Neurology, vol. 22 no. 4 (August, 2009), pp. 379-386 [19542887], [doi]  [abs].
  18. Howles, GP; Nouls, JC; Qi, Y; Johnson, GA, Rapid production of specialized animal handling devices using computer-aided design and solid freeform fabrication., Journal of Magnetic Resonance Imaging, vol. 30 no. 2 (August, 2009), pp. 466-471 [19629999], [doi]  [abs].
  19. Badea, A; Johnson, GA; Williams, RW, Genetic dissection of the mouse brain using high-field magnetic resonance microscopy., NeuroImage, vol. 45 no. 4 (May, 2009), pp. 1067-1079 [19349225], [doi]  [abs].
  20. MacKenzie-Graham, A; Tiwari-Woodruff, SK; Sharma, G; Aguilar, C; Vo, KT; Strickland, LV; Morales, L; Fubara, B; Martin, M; Jacobs, RE; Johnson, GA; Toga, AW; Voskuhl, RR, Purkinje cell loss in experimental autoimmune encephalomyelitis, NeuroImage, vol. 48 no. 4 (2009), pp. 637-651 [doi]  [abs].
  21. Goddeeris, MM; Rho, S; Petiet, A; Davenport, CL; Johnson, GA; Meyers, EN; Klingensmith, J, Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart., Development (Cambridge), vol. 135 no. 10 (May, 2008), pp. 1887-1895 [18441277], [doi]  [abs].
  22. Badea, CT; Johnston, S; Johnson, B; Lin, M; Hedlund, LW; Johnson, GA, A dual micro-CT system for small animal imaging., Proceedings of SPIE - The International Society for Optical Engineering, vol. 6913 (April, 2008), pp. 691342 [22049304], [doi]  [abs].
  23. Nouls, JC; Izenson, MG; Greeley, HP; Johnson, GA, Design of a superconducting volume coil for magnetic resonance microscopy of the mouse brain., Journal of Magnetic Resonance, vol. 191 no. 2 (April, 2008), pp. 231-238 [18221901], [doi]  [abs].
  24. Bucholz, EK; Song, J; Johnson, GA; Hancu, I, Multispectral imaging with three-dimensional rosette trajectories., Magnetic Resonance in Medicine, vol. 59 no. 3 (March, 2008), pp. 581-589 [18306410], [doi]  [abs].
  25. Mistry, NN; Pollaro, J; Song, J; De Lin, M; Johnson, GA, Pulmonary perfusion imaging in the rodent lung using dynamic contrast-enhanced MRI., Magnetic Resonance in Medicine, vol. 59 no. 2 (February, 2008), pp. 289-297 [18228577], [doi]  [abs].
  26. Sharief, AA; Badea, A; Dale, AM; Johnson, GA, Automated segmentation of the actively stained mouse brain using multi-spectral MR microscopy., NeuroImage, vol. 39 no. 1 (January, 2008), pp. 136-145 [17933556], [doi]  [abs].
  27. Driehuys, B; Walker, J; Pollaro, J; Cofer, GP; Mistry, N; Schwartz, D; Johnson, GA, 3He MRI in mouse models of asthma., Magnetic Resonance in Medicine, vol. 58 no. 5 (November, 2007), pp. 893-900 [17969115], [doi]  [abs].
  28. Chen, BT; Johnson, GA, Dynamic lung morphology of methacholine-induced heterogeneous bronchoconstriction., Magnetic Resonance in Medicine, vol. 52 no. 5 (November, 2004), pp. 1080-1086 [15508158], [doi]  [abs].
  29. Morgan, DL; Little, PB; Herr, DW; Moser, VC; Collins, B; Herbert, R; Johnson, GA; Maronpot, RR; Harry, GJ; Sills, RC, Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks., Toxicology and Applied Pharmacology, vol. 200 no. 2 (October, 2004), pp. 131-145 [15476866], [doi]  [abs].
  30. Sills, RC; Morgan, DL; Herr, DW; Little, PB; George, NM; Ton, TV; Love, NE; Maronpot, RR; Johnson, GA, Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats., Toxicologic Pathology (Sage), vol. 32 no. 5 (September, 2004), pp. 501-510 [doi]  [abs].
  31. Brau, AC; Hedlund, LW; Johnson, GA, Cine magnetic resonance microscopy of the rat heart using cardiorespiratory-synchronous projection reconstruction., Journal of Magnetic Resonance Imaging, vol. 20 no. 1 (July, 2004), pp. 31-38 [15221806], [doi]  [abs].
  32. Segars, WP; Tsui, BM; Frey, EC; Johnson, GA; Berr, SS, Development of a 4-D digital mouse phantom for molecular imaging research., Molecular Imaging and Biology, vol. 6 no. 3 (May, 2004), pp. 149-159 [15193249], [doi]  [abs].
  33. G. A. Johnson and G. P. Cofer and S. L. Gewalt and L. W. Hedlund, Morphologic phenotyping with MR microscopy: The visible mouse, Radiology, vol. 222 no. 3 (March, 2002), pp. 789 -- 793 .
  34. Johnson, GA; Cofer, GP; Gewalt, SL; Hedlund, LW, Morphologic phenotyping with MR microscopy: the visible mouse., Radiology, vol. 222 no. 3 (March, 2002), pp. 789-793 [11867802], [doi]  [abs].
  35. A. C. S. Brau and C. T. Wheeler and L. W. Hedlund and G. A. Johnson, Fiber-optic stethoscope: A cardiac monitoring and gating system for magnetic resonance microscopy, Magnetic Resonance In Medicine, vol. 47 no. 2 (February, 2002), pp. 314 -- 321 .
  36. H. E. Moller and L. W. Hedlund and X. J. Chen and M. R. Carey and M. S. Chawla and C. T. Wheeler and G. A. Johnson, Measurements of hyperpolarized gas properties in the lung. Part III: He-3 T-1, Magnetic Resonance In Medicine, vol. 45 no. 3 (March, 2001), pp. 421 -- 430 .
  37. Johnson, GA; Cofer, GP; Hedlund, LW; Maronpot, RR; Suddarth, SA, Registered (1)H and (3)He magnetic resonance microscopy of the lung., Magnetic Resonance in Medicine, vol. 45 no. 3 (March, 2001), pp. 365-370 [11241691], [doi]  [abs].
  38. Johnson, GA; Cofer, GP; Hedlund, LW; Maronpot, RR; Suddarth, SA, Registered 1H and 3He magnetic resonance microscopy of the lung, Magnetic Resonance in Medicine, vol. 45 no. 3 (2001), pp. 365-370 [doi]  [abs].
  39. M. S. Chawla and X. J. Chen and G. P. Cofer and L. W. Hedlund and M. B. Kerby and T. B. Ottoboni and G. A. Johnson, Hyperpolarized He-3 microspheres as a novel vascular signal source for MRI, Magnetic Resonance In Medicine, vol. 43 no. 3 (March, 2000), pp. 440 -- 445 .
  40. Benveniste, H; Einstein, G; Kim, KR; Hulette, C; Johnson, GA, Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy., Proceedings of the National Academy of Sciences of USA, vol. 96 no. 24 (November, 1999), pp. 14079-14084 [10570201]  [abs].
  41. Hurlston, SE; Brey, WW; Suddarth, SA; Johnson, GA, A high-temperature superconducting Helmholtz probe for microscopy at 9.4 T., Magnetic Resonance in Medicine, vol. 41 no. 5 (May, 1999), pp. 1032-1038 [10332887]  [abs].
  42. SE Hurlston, WW Brey, SA Suddarth, GA Johnson, A high-temperature superconducting Helmholtz probe for microscopy at 9.4 T., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, UNITED STATES, vol. 41 no. 5 (May, 1999), pp. 1032-8  [abs].
  43. Möller, HE; Chawla, MS; Chen, XJ; Driehuys, B; Hedlund, LW; Wheeler, CT; Johnson, GA, Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion., Magnetic Resonance in Medicine, vol. 41 no. 5 (May, 1999), pp. 1058-1064 [10332890]  [abs].
  44. M. Delnomdedieu and L. W. Hedlund and R. R. Maronpot and G. A. Johnson, Magnetic resonance microscopy and histopathology: Comparative approach of bromobenzene-induced hepatotoxicity in the rat, Hepatology, vol. 27 no. 2 (February, 1998), pp. 526 -- 532 .
  45. Johnson, GA; Hedlund, L; MacFall, J, A new window into the lung, Physics World, vol. 11 no. 11 (1998), pp. 35-38 .
  46. R.T. Engelhardt, G.A. Johnson, T1r relaxation and its application to MR  histology.  Magnetic Resonance in Medicine 35, 781-786 (1996). .
  47. L.W. Hedlund, M.D. Shattuck, G.A. Johnson.  Three-dimensional MR  microscopy of pulmonary dynamics.  in "Proc., 1996.  New York, NY,  1996," p.327. .
  48. G.A. Johnson, G. Cates, X.J. Chen, G.P. Cofer,  B. Driehuys, W. Happer,  L.W. Hedlund, B. Saam, M. Shattuck, J. Swartz.  Dynamics of  magnetization in hyperpolarized gas MRI of the lung.  Magnetic Resonance  in Medicine submitted (1996). .
  49. Johnson, GA; Maki, JH, In vivo measurement of proton diffusion in the presence of coherent motion., Investigative Radiology, vol. 26 no. 6 (June, 1991), pp. 540-545 [1650333]  [abs].

Highlight:
Dr. Johnson is the Charles E. Putman University Professor of Radiology, Professor of Physics, and Biomedical Engineering, and Director of the Duke Center for In Vivo Microscopy (CIVM). The CIVM is an NIH/NIBIB national Biomedical Technology Resource Center with a mission to develop novel technologies for preclinical imaging (basic sciences) and apply the technologies to critical biomedical questions. Dr. Johnson was one of the first researchers to bring Paul Lauterbur's vision of magnetic resonance (MR) microscopy to practice as described in his paper, "Nuclear magnetic resonance imaging at microscopic resolution" (J Magn Reson 68:129-137, 1986). Dr. Johnson is involved in both the engineering physics required to extend the resolution of MR imaging and in a broad range of applications in the basic sciences.