G. Allan Johnson, Charles E. Putman University Professor of Radiology and Professor of Physics and Member of Duke Cancer Institute  

G. Allan Johnson

Office Location: 141D Bryan Neuroscience Bldg, Research Drive, Durham, NC 27710
Office Phone: (919) 684-7754
Email Address: gjohnson@duke.edu
Web Page: http://www.civm.duhs.duke.edu/

Specialties:
Medical Imaging

Education:
Ph.D., Duke University, 1974

Research Categories: Medical Physics

Research Description: Dr. Johnson is the Charles E. Putman University Professor of Radiology, Physics, and Biomedical Engineering and Director of the Duke Center for In Vivo Microscopy (CIVM). The CIVM is an NIH NCRR/NIBIB national Biomedical Technology Resource Center with a mission to develop novel technologies for preclinical imaging (basic sciences) and apply the technologies to critical biomedical questions. Dr. Johnson was one of the first researchers to bring Paul Lauterbur's vision of magnetic resonance (MR) microscopy to practice as described in his paper, "Nuclear magnetic resonance imaging at microscopic resolution" (J Magn Reson 68:129-137, 1986). He is involved in both the engineering physics required to extend the resolution of MR imaging and in a broad range of applications in the basic sciences.

Areas of Interest:
magnetic resonance histology
magnetic resonance imaging
small animal imaging

Representative Publications   (More Publications)

  1. E Calabrese and GA Johnson, Diffusion tensor magnetic resonance histology reveals microstructural changes in the developing rat brain., Neuroimage, vol. 79 (October, 2013), pp. 329-339 [23648962], [doi]  [abs].
  2. E Calabrese, A Badea, C Watson and GA Johnson, A quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability., Neuroimage, vol. 71 (May, 2013), pp. 196-206 [23353030], [doi]  [abs].
  3. E Calabrese, GA Johnson and C Watson, An ontology-based segmentation scheme for tracking postnatal changes in the developing rodent brain with MRI., Neuroimage, vol. 67 (February, 2013), pp. 375-384 [23246176], [doi]  [abs].
  4. CT Badea, LW Hedlund and GA Johnson, A LabVIEW Platform for Preclinical Imaging Using Digital Subtraction Angiography and Micro-CT., Journal of medical engineering, vol. 2013 no. 581617 (January, 2013), pp. 581617 [repository], [doi]  [abs].
  5. D Perperidis, E Bucholz, GA Johnson and C Constantinides, Morphological studies of the murine heart based on probabilistic and statistical atlases., Comput Med Imaging Graph, vol. 36 no. 2 (March, 2012), pp. 119-129 [21820867], [doi]  [abs].
  6. C Liu, W Li, B Wu, Y Jiang and GA Johnson, 3D fiber tractography with susceptibility tensor imaging., Neuroimage, vol. 59 no. 2 (January, 2012), pp. 1290-1298 [21867759], [doi]  [abs].
  7. A Badea and GA Johnson, Magnetic resonance microscopy., in Studies in Health Technology and Informatics, Anal Cell Pathol (Amst), vol. 35 no. 4 (2012), pp. 205-227, IOS Press Ebooks [22142643], [doi]  [abs].
  8. BT Antonsen, Y Jiang, J Veraart, H Qu, HP Nguyen, J Sijbers, SV Hörsten, GA Johnson and TB Leergaard, Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats, Brain Structure and Function, vol. 218 no. 3 (2012), pp. 1-12 [doi]  [abs].
  9. Y Jiang and GA Johnson, Microscopic diffusion tensor atlas of the mouse brain., Neuroimage, vol. 56 no. 3 (June, 2011), pp. 1235-1243 [21419226], [doi]  [abs].
  10. C Liu, W Li, GA Johnson and B Wu, High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility., Neuroimage, vol. 56 no. 3 (June, 2011), pp. 930-938 [21320606], [doi]  [abs].
  11. DM Bowden, GA Johnson, L Zaborsky, WD Green, E Moore, A Badea, MF Dubach and FL Bookstein, A symmetrical Waxholm canonical mouse brain for NeuroMaps., J Neurosci Methods, vol. 195 no. 2 (February, 2011), pp. 170-175 [21163300], [doi]  [abs].
  12. P Pandit, Y Qi, KF King and GA Johnson, Reduction of artifacts in T2 -weighted PROPELLER in high-field preclinical imaging., Magn Reson Med, vol. 65 no. 2 (February, 2011), pp. 538-543 [20928875], [doi]  [abs].
  13. M Hawrylycz, RA Baldock, A Burger, T Hashikawa, GA Johnson, M Martone, L Ng, C Lau, SD Larson, J Nissanov, L Puelles, S Ruffins, F Verbeek, I Zaslavsky and J Boline, Digital atlasing and standardization in the mouse brain., PLoS Comput Biol, vol. 7 no. 2 (2011), pp. e1001065 [21304938], [doi] .
  14. E Bucholz, K Ghaghada, Y Qi, S Mukundan, HA Rockman and GA Johnson, Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA., Magn Reson Med, vol. 63 no. 4 (April, 2010), pp. 979-987 [20373399], [doi]  [abs].
  15. A Badea, GA Johnson and JL Jankowsky, Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease., Neuroimage, vol. 50 no. 2 (April, 2010), pp. 416-427 [20035883], [doi]  [abs].
  16. Y Jiang and GA Johnson, Microscopic diffusion tensor imaging of the mouse brain., Neuroimage, vol. 50 no. 2 (April, 2010), pp. 465-471 [20034583], [doi]  [abs].
  17. A Badea, GA Johnson and RW Williams, Genetic dissection of the mouse CNS using magnetic resonance microscopy., Curr Opin Neurol, vol. 22 no. 4 (August, 2009), pp. 379-386 [19542887], [doi]  [abs].
  18. GP Howles, JC Nouls, Y Qi and GA Johnson, Rapid production of specialized animal handling devices using computer-aided design and solid freeform fabrication., J Magn Reson Imaging, vol. 30 no. 2 (August, 2009), pp. 466-471 [19629999], [doi]  [abs].
  19. A Badea, GA Johnson and RW Williams, Genetic dissection of the mouse brain using high-field magnetic resonance microscopy., Neuroimage, vol. 45 no. 4 (May, 2009), pp. 1067-1079 [19349225], [doi]  [abs].
  20. A MacKenzie-Graham, SK Tiwari-Woodruff, G Sharma, C Aguilar, KT Vo, LV Strickland, L Morales, B Fubara, M Martin, RE Jacobs, GA Johnson, AW Toga and RR Voskuhl, Purkinje cell loss in experimental autoimmune encephalomyelitis, NeuroImage, vol. 48 no. 4 (2009), pp. 637-651 [doi]  [abs].
  21. MM Goddeeris, S Rho, A Petiet, CL Davenport, GA Johnson, EN Meyers and J Klingensmith, Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart., Development, vol. 135 no. 10 (May, 2008), pp. 1887-1895 [18441277], [doi]  [abs].
  22. CT Badea, S Johnston, B Johnson, M Lin, LW Hedlund and GA Johnson, A dual micro-CT system for small animal imaging., Proc SPIE Int Soc Opt Eng, vol. 6913 (April, 2008), pp. 691342 [22049304], [doi]  [abs].
  23. JC Nouls, MG Izenson, HP Greeley and GA Johnson, Design of a superconducting volume coil for magnetic resonance microscopy of the mouse brain., J Magn Reson, vol. 191 no. 2 (April, 2008), pp. 231-238 [18221901], [doi]  [abs].
  24. EK Bucholz, J Song, GA Johnson and I Hancu, Multispectral imaging with three-dimensional rosette trajectories., Magn Reson Med, vol. 59 no. 3 (March, 2008), pp. 581-589 [18306410], [doi]  [abs].
  25. NN Mistry, J Pollaro, J Song, M De Lin and GA Johnson, Pulmonary perfusion imaging in the rodent lung using dynamic contrast-enhanced MRI., Magn Reson Med, vol. 59 no. 2 (February, 2008), pp. 289-297 [18228577], [doi]  [abs].
  26. AA Sharief, A Badea, AM Dale and GA Johnson, Automated segmentation of the actively stained mouse brain using multi-spectral MR microscopy., Neuroimage, vol. 39 no. 1 (January, 2008), pp. 136-145 [17933556], [doi]  [abs].
  27. B Driehuys, J Walker, J Pollaro, GP Cofer, N Mistry, D Schwartz and GA Johnson, 3He MRI in mouse models of asthma., Magn Reson Med, vol. 58 no. 5 (November, 2007), pp. 893-900 [17969115], [doi]  [abs].
  28. BT Chen and GA Johnson, Dynamic lung morphology of methacholine-induced heterogeneous bronchoconstriction., Magn Reson Med, vol. 52 no. 5 (November, 2004), pp. 1080-1086 [15508158], [doi]  [abs].
  29. DL Morgan, PB Little, DW Herr, VC Moser, B Collins, R Herbert, GA Johnson, RR Maronpot, GJ Harry and RC Sills, Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks., Toxicol Appl Pharmacol, vol. 200 no. 2 (October, 2004), pp. 131-145 [15476866], [doi]  [abs].
  30. AC Brau, LW Hedlund and GA Johnson, Cine magnetic resonance microscopy of the rat heart using cardiorespiratory-synchronous projection reconstruction., J Magn Reson Imaging, vol. 20 no. 1 (July, 2004), pp. 31-38 [15221806], [doi]  [abs].
  31. WP Segars, BM Tsui, EC Frey, GA Johnson and SS Berr, Development of a 4-D digital mouse phantom for molecular imaging research., Mol Imaging Biol, vol. 6 no. 3 (May, 2004), pp. 149-159 [15193249], [doi]  [abs].
  32. RC Sills, DL Morgan, DW Herr, PB Little, NM George, TV Ton, NE Love, RR Maronpot and GA Johnson, Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats, Toxicologic Pathology, vol. 32 no. 5 (2004), pp. 501-510 [doi]  [abs].
  33. G. A. Johnson and G. P. Cofer and S. L. Gewalt and L. W. Hedlund, Morphologic phenotyping with MR microscopy: The visible mouse, Radiology, vol. 222 no. 3 (March, 2002), pp. 789 -- 793 .
  34. GA Johnson, GP Cofer, SL Gewalt and LW Hedlund, Morphologic phenotyping with MR microscopy: the visible mouse., Radiology, vol. 222 no. 3 (March, 2002), pp. 789-793 [11867802], [doi]  [abs].
  35. A. C. S. Brau and C. T. Wheeler and L. W. Hedlund and G. A. Johnson, Fiber-optic stethoscope: A cardiac monitoring and gating system for magnetic resonance microscopy, Magnetic Resonance In Medicine, vol. 47 no. 2 (February, 2002), pp. 314 -- 321 .
  36. H. E. Moller and L. W. Hedlund and X. J. Chen and M. R. Carey and M. S. Chawla and C. T. Wheeler and G. A. Johnson, Measurements of hyperpolarized gas properties in the lung. Part III: He-3 T-1, Magnetic Resonance In Medicine, vol. 45 no. 3 (March, 2001), pp. 421 -- 430 .
  37. G. A. Johnson and G. P. Cofer and L. W. Hedlund and R. R. Maronpot and S. A. Suddarth, Registered H-1 and He-3 magnetic resonance microscopy of the lung, Magnetic Resonance In Medicine, vol. 45 no. 3 (March, 2001), pp. 365 -- 370 .
  38. GA Johnson, GP Cofer, LW Hedlund, RR Maronpot and SA Suddarth, Registered (1)H and (3)He magnetic resonance microscopy of the lung., Magn Reson Med, vol. 45 no. 3 (March, 2001), pp. 365-370 [11241691], [doi]  [abs].
  39. M. S. Chawla and X. J. Chen and G. P. Cofer and L. W. Hedlund and M. B. Kerby and T. B. Ottoboni and G. A. Johnson, Hyperpolarized He-3 microspheres as a novel vascular signal source for MRI, Magnetic Resonance In Medicine, vol. 43 no. 3 (March, 2000), pp. 440 -- 445 .
  40. H Benveniste, G Einstein, KR Kim, C Hulette and GA Johnson, Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy., Proc Natl Acad Sci U S A, vol. 96 no. 24 (November, 1999), pp. 14079-14084 [10570201]  [abs].
  41. SE Hurlston, WW Brey, SA Suddarth and GA Johnson, A high-temperature superconducting Helmholtz probe for microscopy at 9.4 T., Magn Reson Med, vol. 41 no. 5 (May, 1999), pp. 1032-1038 [10332887]  [abs].
  42. SE Hurlston, WW Brey, SA Suddarth, GA Johnson, A high-temperature superconducting Helmholtz probe for microscopy at 9.4 T., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, UNITED STATES, vol. 41 no. 5 (May, 1999), pp. 1032-8  [abs].
  43. HE Möller, MS Chawla, XJ Chen, B Driehuys, LW Hedlund, CT Wheeler and GA Johnson, Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion., Magn Reson Med, vol. 41 no. 5 (May, 1999), pp. 1058-1064 [10332890]  [abs].
  44. M. Delnomdedieu and L. W. Hedlund and R. R. Maronpot and G. A. Johnson, Magnetic resonance microscopy and histopathology: Comparative approach of bromobenzene-induced hepatotoxicity in the rat, Hepatology, vol. 27 no. 2 (February, 1998), pp. 526 -- 532 .
  45. GA Johnson, L Hedlund and J MacFall, A new window into the lung, Physics World, vol. 11 no. 11 (1998), pp. 35-38 .
  46. R.T. Engelhardt, G.A. Johnson, T1r relaxation and its application to MR  histology.  Magnetic Resonance in Medicine 35, 781-786 (1996). .
  47. L.W. Hedlund, M.D. Shattuck, G.A. Johnson.  Three-dimensional MR  microscopy of pulmonary dynamics.  in "Proc., 1996.  New York, NY,  1996," p.327. .
  48. G.A. Johnson, G. Cates, X.J. Chen, G.P. Cofer,  B. Driehuys, W. Happer,  L.W. Hedlund, B. Saam, M. Shattuck, J. Swartz.  Dynamics of  magnetization in hyperpolarized gas MRI of the lung.  Magnetic Resonance  in Medicine submitted (1996). .
  49. GA Johnson and JH Maki, In vivo measurement of proton diffusion in the presence of coherent motion., Invest Radiol, vol. 26 no. 6 (June, 1991), pp. 540-545 [1650333]  [abs].

Highlight:
Dr. Johnson is the Charles E. Putman University Professor of Radiology, Professor of Physics, and Biomedical Engineering, and Director of the Duke Center for In Vivo Microscopy (CIVM). The CIVM is an NIH/NIBIB national Biomedical Technology Resource Center with a mission to develop novel technologies for preclinical imaging (basic sciences) and apply the technologies to critical biomedical questions. Dr. Johnson was one of the first researchers to bring Paul Lauterbur's vision of magnetic resonance (MR) microscopy to practice as described in his paper, "Nuclear magnetic resonance imaging at microscopic resolution" (J Magn Reson 68:129-137, 1986). Dr. Johnson is involved in both the engineering physics required to extend the resolution of MR imaging and in a broad range of applications in the basic sciences.