G. Allan Johnson, Professor of Radiology and Physics  

G. Allan Johnson

Office Location: 141D Bryan Research Building for Neurobiology
Office Phone: (919) 684-7754
Email Address: gaj@orion.duhs.duke.edu
Web Page: http://www.civm.duhs.duke.edu/

Specialties:
Medical Imaging

Education:
PhD, Duke University, 1974
Ph.D., Duke University, 1974

Research Categories: Medical Physics

Research Description: I have spent the last thirty one years engaged in building and applying advanced imaging technologies ranging from work on the first CT scanner installed at Duke (1974) to installation of the world's first high filed (1.5 T) clinical MRI system (1983). I continue to serve the medical center in commissioning new imaging technologies. Since 1983 my research has focused on extending the resolution of magnetic resonance imaging from the clinical domain, typically with voxels of 1 x 1 x 1 mm to the microscopic domain required for basic research in small animal models with voxels 125,000X smaller. The Center for In Vivo Microscopy was founded in 1985 and continues today with generous support from the National Center for Research Resources (P41 RR005959). The Center currently supports 6 state-of-the-art imaging systems for small animal imaging: 3 MRI systems (2, 7, and 9.4 T), a micro x-ray system, a micro- CT system, and a microPET system. The Center has embarked on an aggressive program to expand these modalities into molecular imaging with support from NCI (R24 CA092656)

Areas of Interest:
magnetic resonance histology
magnetic resonance imaging
small animal imaging

Representative Publications   (More Publications)

  1. AA Ali, AM Dale, A Badea, GA Johnson, Automated segmentation of neuroanatomical structures in multispectral MR microscopy of the mouse brain., NeuroImage, United States, vol. 27 no. 2 (August, 2005), pp. 425-35  [abs].
  2. Hurlston SE, Brey WW, Suddarth SA, Yap M, Johson GA. A high temperature superconducting Helmholtz probe for microscopy at 9.4 T Magn Res Med. In press 1998 .
  3. W Maï, CT Badea, CT Wheeler, LW Hedlund, GA Johnson, Effects of breathing and cardiac motion on spatial resolution in the microscopic imaging of rodents., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 53 no. 4 (April, 2005), pp. 858-65  [abs].
  4. Johnson GA, Hedlund LW, MacFall JR. A new window into the lung. Physics in Medicine 35-38 1998 .
  5. M Cyr, MG Caron, GA Johnson, A Laakso, Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction., NeuroImage, United States, vol. 26 no. 1 (May, 2005), pp. 83-90  [abs].
  6. Miller JR, Hurlston SE, Face DW, Kountz DJ, MacFall JR, Hedlund LW, Ma QY, Johnson GA. Performance of a high-temperature superconducting probe for in vivo microsopy at 2.0 T Magn Reson Med. In press 1998 .
  7. BT Chen, AT Yordanov, GA Johnson, Ventilation-synchronous magnetic resonance microscopy of pulmonary structure and ventilation in mice., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 53 no. 1 (January, 2005), pp. 69-75  [abs].
  8. Viallon M, Cofer GP, Suddarth SA, Msller H, Chen XJ, Chawla MS, Hedlund LW, Cr Millieux Y, Johson GA. Functional MR microscopy of the lung with hyperpolarized 3He. Mag Reson Med. In press 1998 .
  9. AC Brau, LW Hedlund, GA Johnson, Cine magnetic resonance microscopy of the rat heart using cardiorespiratory-synchronous projection reconstruction., Journal of magnetic resonance imaging : JMRI, United States, vol. 20 no. 1 (July, 2004), pp. 31-8  [abs].
  10. A. LeFurgey, S. Gewalt, N. Wallace, D. Kopf, G.A. Johnson, P. Ingram.   Magnetic Resonance Microscoopy of the Adult Barnacle.  in "Proc.,  MicroCosmopolitan (14th Australian Conference on Electron Microscopy,  1st Meeting, International Union of Microbeam Analysis Societies, 9th  Symposium of the Microscopical Society of Australia).  Syndey, Australia,  1996," p. 105. .
  11. BT Chen, GA Johnson, Dynamic lung morphology of methacholine-induced heterogeneous bronchoconstriction., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 52 no. 5 (November, 2004), pp. 1080-6  [abs].
  12. C. Zimmer,  S.C.J. Wright, R.T. Engelhardt, G.A. Johnson, X.O. Breakefield,  R. Weissleder.  Tumor cell endocytosi (TCE) imaging facilitates delineation  of the glioma-brain interface. (1996). .
  13. X Zhang, M Tengowski, L Fasulo, S Botts, SA Suddarth, GA Johnson, Measurement of fat/water ratios in rat liver using 3D three-point dixon MRI., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 51 no. 4 (April, 2004), pp. 697-702  [abs].
  14. G.A. Johnson, G. Cates, X.J. Chen, G.P. Cofer,  B. Driehuys, W. Happer,  L.W. Hedlund, B. Saam, M. Shattuck, J. Swartz.  Dynamics of  magnetization in hyperpolarized gas MRI of the lung.  Magnetic Resonance  in Medicine submitted (1996). .
  15. C Badea, LW Hedlund, GA Johnson, Micro-CT with respiratory and cardiac gating., Medical physics, United States, vol. 31 no. 12 (December, 2004), pp. 3324-9  [abs].
  16. G.A. Johnson, H. Beneveniste, R.T. Engelhardt, H. Qiu, L. W. Hedlund,  Magnetic resonance microscopy in basic studies of brain structure and  function.  New York Academy of Sciences.  In press (1996). .
  17. TM Yelbuz, X Zhang, MA Choma, HA Stadt, M Zdanowicz, GA Johnson, ML Kirby, Images in cardiovascular medicine. Approaching cardiac development in three dimensions by magnetic resonance microscopy., Circulation, United States, vol. 108 no. 22 (December, 2003), pp. e154-5 .
  18. G.A. Johnson, L.W. Hedlund.  Functional imaging of the lung.  Nature  Medicine 2, 1192 (1996). .
  19. X Zhang, TM Yelbuz, GP Cofer, MA Choma, ML Kirby, GA Johnson, Improved preparation of chick embryonic samples for magnetic resonance microscopy., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 49 no. 6 (June, 2003), pp. 1192-5  [abs].
  20. G.A. Johnson, R.D. Black, G.D. Cates, X.J. Chen, B. Driehuys, W. Happer,  L.W. Hedlund, H. Middleton, M.D. Shattuck, J. Swartz.  Polarization  dynamics of hyperpolarized 3He in lung imaging.  in "Proc., SMR 4th Annual  Scientific Meeting.  New York, NY, 1996," p. 19. .
  21. BT Chen, AC Brau, GA Johnson, Measurement of regional lung function in rats using hyperpolarized 3helium dynamic MRI., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 49 no. 1 (January, 2003), pp. 78-88  [abs].
  22. H. Qiu, L.W. Hedlund, H. Benveniste, S.L. Gewalt, G.A. Johnson.   Evaluation of a glycine antagonist in rat focal cerebral ischemia by  diffusion-weighted MR microscopy.  in "Proc., SMR 4th Annual Scientific  Meeting.  New York, NY, 1996," p. 505. .
  23. AC Brau, CT Wheeler, LW Hedlund, GA Johnson, Fiber-optic stethoscope: a cardiac monitoring and gating system for magnetic resonance microscopy., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 47 no. 2 (February, 2002), pp. 314-21  [abs].
  24. J.R. MacFall, H.C.Charles, R.D. Black, H. Middleton, J.Swartz, B. Saam,   B. Dreihuys, C. Erickson, W. Happer, G. Cates, G.A. Johnson, C.E. Ravin.   Human lung air spaces: potential for MR imaging with hyperpolarized He-3.   Radiology 200, 553-558. (1996). .
  25. GA Johnson, GP Cofer, B Fubara, SL Gewalt, LW Hedlund, RR Maronpot, Magnetic resonance histology for morphologic phenotyping., Journal of magnetic resonance imaging : JMRI, United States, vol. 16 no. 4 (October, 2002), pp. 423-9  [abs].
  26. J.R. MacFall, H.C.Charles, R.D. Black, H. Middleton, J.Swartz, B. Saam,   W. Happer, G. Cates, G.A. Johnson, C.E. Ravin. MR imaging of lung air  spaces with hyperpolarized 3He.  in "Proc., SMR 4th Annual Scientific  Meeting.  New York, NY, 1996," p. 21. .
  27. LW Hedlund, GA Johnson, Mechanical ventilation for imaging the small animal lung., ILAR journal / National Research Council, Institute of Laboratory Animal Resources, United States, vol. 43 no. 3 (2002), pp. 159-74  [abs].
  28. J.S. MacFall, G.A. Johnson, in "Encyclopedia of Nuclear Magnetic  Resonance" (D.M. Grant, R.K. Harris, Ed.), p. 3633-3640, John Wiley &  Sons, London, 1996. .
  29. GA Johnson, GP Cofer, SL Gewalt, LW Hedlund, Morphologic phenotyping with MR microscopy: the visible mouse., Radiology, United States, vol. 222 no. 3 (March, 2002), pp. 789-93  [abs].
  30. L.W. Hedlund, M.D. Shattuck, G.A. Johnson.  Three-dimensional MR  microscopy of pulmonary dynamics.  in "Proc., 1996.  New York, NY,  1996," p.327. .
  31. HE Möller, LW Hedlund, XJ Chen, MR Carey, MS Chawla, CT Wheeler, GA Johnson, Measurements of hyperpolarized gas properties in the lung. Part III: (3)He T(1)., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 45 no. 3 (March, 2001), pp. 421-30  [abs].
  32. L.W. Hedlund, S.L. Gewalt, G.P. Cofer, G.A. Johnson, in "Application of  Magnetic Resonance to the Study of the Lung" (A. Cutillo, Ed.), p. 401-415,  Futura Press, Mt. Kisko, NY, 1996. .
  33. GA Johnson, GP Cofer, LW Hedlund, RR Maronpot, SA Suddarth, Registered (1)H and (3)He magnetic resonance microscopy of the lung., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 45 no. 3 (March, 2001), pp. 365-70  [abs].
  34. M. Delnomdedieu, L. W. Hedlund, R.R. Maronpot, G.A. Johnson. MR  microscopy to follow bromobenzene-induced hepatoxicity in the rat. in  "Proc., SMR 4th Annual Scientific Meeting.  New York, NY, 1996," p.325. .
  35. H Benveniste, K Kim, L Zhang, GA Johnson, Magnetic resonance microscopy of the C57BL mouse brain., NeuroImage, UNITED STATES, vol. 11 no. 6 Pt 1 (June, 2000), pp. 601-11  [abs].
  36. M. Delnomdedieu, L.W. Hedlund, G.A. Johnson, R.R. Maronpot, Magnetic  Resonance Microscopy-A New Tool for the Toxicologic Pathologist.   Toxicologic Pathology 24, 36-44 (1996). .
  37. SE Hurlston, WW Brey, SA Suddarth, GA Johnson, A high-temperature superconducting Helmholtz probe for microscopy at 9.4 T., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, UNITED STATES, vol. 41 no. 5 (May, 1999), pp. 1032-8  [abs].
  38. M.D. Shattuck, G.P. Cofer, G.H. Glover, L.W. Hedlund, G.A. Johnson.    Three-dimensional projection microscopy of the lung. in "Proc., SMR 4th  Scientific Meeting.  New York, NY, 1996," p. 18. .
  39. H Benveniste, G Einstein, KR Kim, C Hulette, GA Johnson, Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy., Proceedings of the National Academy of Sciences of the United States of America, UNITED STATES, vol. 96 no. 24 (November, 1999), pp. 14079-84  [abs].
  40. R.D. Black, H. Middleton, G.D. Cates, G.P. Cofer, B. Driehuys, W. Happer,   L. W. Hedlund, G.A. Johnson, M.D. Shattuck, J. Swartz, In vivo He-3 MR   Images of guinea pig lungs.  Radiology 199, 867-870 (1996). .
  41. M Viallon, GP Cofer, SA Suddarth, HE Möller, XJ Chen, MS Chawla, LW Hedlund, Y Crémillieux, GA Johnson, Functional MR microscopy of the lung using hyperpolarized 3He., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, UNITED STATES, vol. 41 no. 4 (April, 1999), pp. 787-92  [abs].
  42. R.T. Engelhardt, G.A. Johnson, T1r relaxation and its application to MR  histology.  Magnetic Resonance in Medicine 35, 781-786 (1996). .
  43. XJ Chen, HE Möller, MS Chawla, GP Cofer, B Driehuys, LW Hedlund, GA Johnson, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, UNITED STATES, vol. 42 no. 4 (October, 1999), pp. 721-8  [abs].
  44. S. Hurlston, R.D. Black, W. Brey, X.J. Chen, L.W. Hedlund, R. Withers,  M.Yap, G.A. Johnson.  A superconducting surface coil for in vivo MR  microscopy. in "Proc., SMR 4th Annual Scientific Meeting.  New York, NY,  1996," p.129. .
  45. XJ Chen, HE Möller, MS Chawla, GP Cofer, B Driehuys, LW Hedlund, JR MacFall, GA Johnson, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2)., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, UNITED STATES, vol. 42 no. 4 (October, 1999), pp. 729-37  [abs].
  46. W. L. Hall, H. Benveniste, L.W. Hedlund, G.A. Johnson, A new in vivo  method for quantitative analysis of stroke lesions using MR microscopy.   NeuroImage 3, 158-166 (1996). .
  47. Delnomdedieu M, Hedlund LW, maronpot RR, Johson GA, MR microscopy and histopathology: Comparative approach to bromobenzene-induced hepatoxicity in the rat. hepatology 27; 526-532 1998 .
  48. 1. C.F. Beaulieu, X. Zhou, G.P. Cofer, G.A. Johnson. Diffusion-Weighted MR Microscopy with Fast Spin-Echo. Magnetic Resonance in Medicine 30, 201-206 (1993). .
  49. 1. Cho ZH, Ro YM. Multipoint K-Space Mapping Technique. Reviewed for Magn Reson. in Med. .
  50. RR Maronpot, RC Sills, GA Johnson, Applications of magnetic resonance microscopy., Toxicologic pathology, United States, vol. 32 Suppl 2 , pp. 42-8  [abs].
  51. 2. H. Benveniste, G. Johnson, in "Microcirculatory Stasis in the Brain" (M. Tomita, Mchedlishvili, W. Roseblum, W.D. Heiss, Y. Fukuuchi, Ed.), p. 369-376, Excerpta Medica, Amsterdam, 1993. .
  52. RC Sills, DL Morgan, DW Herr, PB Little, NM George, TV Ton, NE Love, RR Maronpot, GA Johnson, Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats., Toxicologic pathology, United States, vol. 32 no. 5 , pp. 501-10  [abs].
  53. 2. Hafner S, Kuhn W. NMR Imaging of Water Contentin Chips. Reviewed for Magn. Reson. Imaging. .
  54. H Benveniste, H Qui, LW Hedlund, F D'Ercole, GA Johnson, Spinal cord neural anatomy in rats examined by in vivo magnetic resonance microscopy., Regional anesthesia and pain medicine, UNITED STATES, vol. 23 no. 6 , pp. 589-99  [abs].
  55. 3. J.C.M. Hsu, G.A. Johnson, W.M. Smith K.A. Reimer, R.E. Ideker. Magnetic Resonance Imaging of Chronic Myocardial Infarcts in Formalin Fixed Human Autopsy Specimens. Circulation 89:2133-2140 (1993). .
  56. 4. X. Zhou, G.P. Cofer S. A. Suddarth, G. A. Johnson. High Field MR Microscopy Using Fast Spin Echoes. Magn Reson Med 30:60-67 (1993). .
  57. 5. X. Zhou, Z. P. Liang, G.P. Cofer, C.F. Beaulieu, S.A. Suddarth, G.A. Johnson. Reduction of Ringing and Blurring Artifacts in Fast Spin-Echo Images. J Magn Reson Imag 3:803-807 (1993). .
  58. 6. M.M. Henson, O.W. Henson, S.L. Gewalt, J.L. Wilson, G. A. Johnson. Imaging the Cochlea by MRM. Hearing Research 75:75-80 (1994). .
  59. 7. J. MacFall, P. Spaine, R. Doudrick, G. Johnson. Alterations in Growth and Water Transport Processes in Fusiform Rust Galls of Pine as Determined by Magnetic Resonance Microsopy. Phytopathology 84:288-293 (1994). .
  60. 8. B.R. Smith, G.A. Johnson, E.V. Groman, E.A. Linney. Magnetic Resonance Microscopy of Mouse Embryos. Proc. Nat. Acad. Sci. USA 91:3530-3533 (1994). .