G. Allan Johnson, Professor of Radiology and Physics  

G. Allan Johnson

Office Location: 141D Bryan Research Building for Neurobiology
Office Phone: (919) 684-7754, (919) 684-7755
Email Address: gjohnson@duke.edu
Web Page: http://www.civm.duhs.duke.edu/

Specialties:
Medical Imaging

Education:
Ph.D., Duke University, 1974

Research Categories: Medical Physics

Research Description: Dr. Johnson is the Charles E. Putman University Professor of Radiology, Physics, and Biomedical Engineering and Director of the Duke Center for In Vivo Microscopy (CIVM). The CIVM is an NIH NCRR/NIBIB national Biomedical Technology Resource Center with a mission to develop novel technologies for preclinical imaging (basic sciences) and apply the technologies to critical biomedical questions. Dr. Johnson was one of the first researchers to bring Paul Lauterbur's vision of magnetic resonance (MR) microscopy to practice as described in his paper, "Nuclear magnetic resonance imaging at microscopic resolution" (J Magn Reson 68:129-137, 1986). He is involved in both the engineering physics required to extend the resolution of MR imaging and in a broad range of applications in the basic sciences.

Areas of Interest:
magnetic resonance histology
magnetic resonance imaging
small animal imaging

Representative Publications   (More Publications)

  1. A. Badea, G.A. Johnson, Magnetic resonance microscopy, in Studies in Health Technology and Informatics, vol. 185 (2013), pp. 153-184, IOS Press Ebooks .
  2. B.T. Antonsen, Y. Jiang, J. Veraart, H. Qu, H.P. Nguyen, J. Sijbers, S. von Hörsten, G.A Johnson, T.B. Leergaard., Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats, Brain Structure and Function, vol. 218 no. 3 (2013), pp. 767-778  [abs].
  3. C. Badea, L. Hedlund, G.A. Johnson, A LabVIEW platform for preclinical imaging using digital subtraction angiography and micro-CT, Journal of Medical Engineering, vol. 2013 no. 581617 (2013), pp. 1-13 [available here] .
  4. E. Calabrese, G.A. Johnson, C. Watson, An ontology-based segmentation scheme for tracking postnatal changes in the developing rodent brain with MRI, Neuroimage, vol. 67 (2013), pp. 375-384 [available here] .
  5. E. Calabrese, A. Badea, C. Watson, G.A. Johnson, A quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability, Neuroimage, vol. 71 (2013), pp. 196-206 [available here] .
  6. E. Calabrese, G.A. Johnson, Diffusion tensor magnetic resonance histology reveals microstructural changes in the developing rat brain, Neuroimage, vol. 79 (2013), pp. 329-339 [available here] .
  7. D Perperidis, E Bucholz, GA Johnson, C Constantinides, Morphological studies of the murine heart based on probabilistic and statistical atlases., Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society, vol. 36 no. 2 (March, 2012), pp. 119-29 [doi]  [abs].
  8. C Liu, W Li, B Wu, Y Jiang, GA Johnson, 3D fiber tractography with susceptibility tensor imaging., NeuroImage, vol. 59 no. 2 (January, 2012), pp. 1290-8 [doi]  [abs].
  9. C Liu, W Li, GA Johnson, B Wu, High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility., NeuroImage, vol. 56 no. 3 (June, 2011), pp. 930-8 [doi]  [abs].
  10. Y Jiang, GA Johnson, Microscopic diffusion tensor atlas of the mouse brain., NeuroImage, vol. 56 no. 3 (June, 2011), pp. 1235-43 [doi]  [abs].
  11. DM Bowden, GA Johnson, L Zaborsky, WD Green, E Moore, A Badea, MF Dubach, FL Bookstein, A symmetrical Waxholm canonical mouse brain for NeuroMaps., Journal of neuroscience methods, vol. 195 no. 2 (February, 2011), pp. 170-5 [doi]  [abs].
  12. P Pandit, Y Qi, KF King, GA Johnson, Reduction of artifacts in T2 -weighted PROPELLER in high-field preclinical imaging., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, vol. 65 no. 2 (February, 2011), pp. 538-43 [doi]  [abs].
  13. M Hawrylycz, RA Baldock, A Burger, T Hashikawa, GA Johnson, M Martone, L Ng, C Lau, SD Larson, SD Larsen, J Nissanov, L Puelles, S Ruffins, F Verbeek, I Zaslavsky, J Boline, Digital atlasing and standardization in the mouse brain., PLoS computational biology, vol. 7 no. 2 (2011), pp. e1001065 [doi] .
  14. Y Jiang, GA Johnson, Microscopic diffusion tensor imaging of the mouse brain., NeuroImage, vol. 50 no. 2 (April, 2010), pp. 465-71 [doi]  [abs].
  15. A Badea, GA Johnson, JL Jankowsky, Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease., NeuroImage, vol. 50 no. 2 (April, 2010), pp. 416-27 [doi]  [abs].
  16. E Bucholz, K Ghaghada, Y Qi, S Mukundan, HA Rockman, GA Johnson, Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, vol. 63 no. 4 (April, 2010), pp. 979-87 [doi]  [abs].
  17. GP Howles, JC Nouls, Y Qi, GA Johnson, Rapid production of specialized animal handling devices using computer-aided design and solid freeform fabrication., Journal of magnetic resonance imaging : JMRI, United States, vol. 30 no. 2 (August, 2009), pp. 466-71  [abs].
  18. A Badea, GA Johnson, RW Williams, Genetic dissection of the mouse CNS using magnetic resonance microscopy., Current opinion in neurology, England, vol. 22 no. 4 (August, 2009), pp. 379-86  [abs].
  19. A Mackenzie-Graham, SK Tiwari-Woodruff, G Sharma, C Aguilar, KT Vo, LV Strickland, L Morales, B Fubara, M Martin, RE Jacobs, GA Johnson, AW Toga, RR Voskuhl, Purkinje cell loss in experimental autoimmune encephalomyelitis., NeuroImage (July, 2009)  [abs].
  20. A Badea, GA Johnson, RW Williams, Genetic dissection of the mouse brain using high-field magnetic resonance microscopy., NeuroImage, United States, vol. 45 no. 4 (May, 2009), pp. 1067-79  [abs].
  21. MM Goddeeris, S Rho, A Petiet, CL Davenport, GA Johnson, EN Meyers, J Klingensmith, Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart., Development (Cambridge, England), England, vol. 135 no. 10 (May, 2008), pp. 1887-95  [abs].
  22. CT Badea, S Johnston, B Johnson, M Lin, LW Hedlund, GA Johnson, A dual micro-CT system for small animal imaging., Proceedings of SPIE, vol. 6913 (April, 2008), pp. 691342 [doi]  [abs].
  23. JC Nouls, MG Izenson, HP Greeley, GA Johnson, Design of a superconducting volume coil for magnetic resonance microscopy of the mouse brain., Journal of magnetic resonance (San Diego, Calif. : 1997), United States, vol. 191 no. 2 (April, 2008), pp. 231-8  [abs].
  24. EK Bucholz, J Song, GA Johnson, I Hancu, Multispectral imaging with three-dimensional rosette trajectories., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 59 no. 3 (March, 2008), pp. 581-9  [abs].
  25. NN Mistry, J Pollaro, J Song, M De Lin, GA Johnson, Pulmonary perfusion imaging in the rodent lung using dynamic contrast-enhanced MRI., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 59 no. 2 (February, 2008), pp. 289-97  [abs].
  26. AA Sharief, A Badea, AM Dale, GA Johnson, Automated segmentation of the actively stained mouse brain using multi-spectral MR microscopy., NeuroImage, United States, vol. 39 no. 1 (January, 2008), pp. 136-45  [abs].
  27. B Driehuys, J Walker, J Pollaro, GP Cofer, N Mistry, D Schwartz, GA Johnson, 3He MRI in mouse models of asthma., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 58 no. 5 (November, 2007), pp. 893-900  [abs].
  28. B. T. Chen and G. A. Johnson, Dynamic lung morphology of methacholine-induced heterogeneous bronchoconstriction, Magnetic Resonance In Medicine, vol. 52 no. 5 (November, 2004), pp. 1080 -- 1086 .
  29. D. L. Morgan and P. B. Little and D. W. Herr and V. C. Moser and B. Collins and R. Herbert and G. A. Johnson and R. R. Maronpot and G. J. Harry and R. C. Sills, Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks, Toxicology And Applied Pharmacology, vol. 200 no. 2 (October, 2004), pp. 131 -- 145 .
  30. A. C. S. Brau and L. W. Hedlund and G. A. Johnson, Cine magnetic resonance microscopy of the rat heart using cardiorespiratory-synchronous projection reconstruction, Journal Of Magnetic Resonance Imaging, vol. 20 no. 1 (July, 2004), pp. 31 -- 38 .
  31. W. P. Segars and B. M. W. Tsui and E. C. Frey and G. A. Johnson and S. S. Berr, Development of a 4-D digital mouse phantom for molecular imaging research, Molecular Imaging And Biology, vol. 6 no. 3 (2004), pp. 149 -- 159 .
  32. R. C. Sills and D. L. Morgan and D. W. Herr and P. B. Little and N. M. George and T. V. Ton and N. E. Love and R. R. Maronpot and G. A. Johnson, Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats, Toxicologic Pathology, vol. 32 no. 5 (2004), pp. 501 -- 510 .
  33. G. A. Johnson and G. P. Cofer and S. L. Gewalt and L. W. Hedlund, Morphologic phenotyping with MR microscopy: The visible mouse, Radiology, vol. 222 no. 3 (March, 2002), pp. 789 -- 793 .
  34. GA Johnson, GP Cofer, SL Gewalt, LW Hedlund, Morphologic phenotyping with MR microscopy: the visible mouse., Radiology, United States, vol. 222 no. 3 (March, 2002), pp. 789-93  [abs].
  35. A. C. S. Brau and C. T. Wheeler and L. W. Hedlund and G. A. Johnson, Fiber-optic stethoscope: A cardiac monitoring and gating system for magnetic resonance microscopy, Magnetic Resonance In Medicine, vol. 47 no. 2 (February, 2002), pp. 314 -- 321 .
  36. H. E. Moller and L. W. Hedlund and X. J. Chen and M. R. Carey and M. S. Chawla and C. T. Wheeler and G. A. Johnson, Measurements of hyperpolarized gas properties in the lung. Part III: He-3 T-1, Magnetic Resonance In Medicine, vol. 45 no. 3 (March, 2001), pp. 421 -- 430 .
  37. G. A. Johnson and G. P. Cofer and L. W. Hedlund and R. R. Maronpot and S. A. Suddarth, Registered H-1 and He-3 magnetic resonance microscopy of the lung, Magnetic Resonance In Medicine, vol. 45 no. 3 (March, 2001), pp. 365 -- 370 .
  38. GA Johnson, GP Cofer, LW Hedlund, RR Maronpot, SA Suddarth, Registered (1)H and (3)He magnetic resonance microscopy of the lung., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 45 no. 3 (March, 2001), pp. 365-70  [abs].
  39. M. S. Chawla and X. J. Chen and G. P. Cofer and L. W. Hedlund and M. B. Kerby and T. B. Ottoboni and G. A. Johnson, Hyperpolarized He-3 microspheres as a novel vascular signal source for MRI, Magnetic Resonance In Medicine, vol. 43 no. 3 (March, 2000), pp. 440 -- 445 .
  40. H Benveniste, G Einstein, KR Kim, C Hulette, GA Johnson, Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy., Proceedings of the National Academy of Sciences of the United States of America, UNITED STATES, vol. 96 no. 24 (November, 1999), pp. 14079-84  [abs].
  41. S. E. Hurlston and W. W. Brey and S. A. Suddarth and G. A. Johnson, A high-temperature superconducting Helmholtz probe for microscopy at 9.4 T, Magnetic Resonance In Medicine, vol. 41 no. 5 (May, 1999), pp. 1032 -- 1038 .
  42. SE Hurlston, WW Brey, SA Suddarth, GA Johnson, A high-temperature superconducting Helmholtz probe for microscopy at 9.4 T., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, UNITED STATES, vol. 41 no. 5 (May, 1999), pp. 1032-8  [abs].
  43. HE Möller, MS Chawla, XJ Chen, B Driehuys, LW Hedlund, CT Wheeler, GA Johnson, Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, UNITED STATES, vol. 41 no. 5 (May, 1999), pp. 1058-64  [abs].
  44. G. A. Johnson and L. Hedlund and J. Macfall, A new window into the lung, Physics World, vol. 11 no. 11 (November, 1998), pp. 35 -- 38 .
  45. M. Delnomdedieu and L. W. Hedlund and R. R. Maronpot and G. A. Johnson, Magnetic resonance microscopy and histopathology: Comparative approach of bromobenzene-induced hepatotoxicity in the rat, Hepatology, vol. 27 no. 2 (February, 1998), pp. 526 -- 532 .
  46. R.T. Engelhardt, G.A. Johnson, T1r relaxation and its application to MR  histology.  Magnetic Resonance in Medicine 35, 781-786 (1996). .
  47. L.W. Hedlund, M.D. Shattuck, G.A. Johnson.  Three-dimensional MR  microscopy of pulmonary dynamics.  in "Proc., 1996.  New York, NY,  1996," p.327. .
  48. G.A. Johnson, G. Cates, X.J. Chen, G.P. Cofer,  B. Driehuys, W. Happer,  L.W. Hedlund, B. Saam, M. Shattuck, J. Swartz.  Dynamics of  magnetization in hyperpolarized gas MRI of the lung.  Magnetic Resonance  in Medicine submitted (1996). .
  49. G. A. Johnson and J. H. Maki, Invivo measurement of proton diffusion in the presence of coherent motion, Investigative Radiology, vol. 26 no. 6 (June, 1991), pp. 540 -- 545 .