Publications [#174116] of G. Allan Johnson

Papers Published
  1. RE TenBrink, DT Pals, DW Harris, GA Johnson, Renin inhibitors containing psi[CH2O] pseudopeptide inserts., Journal of medicinal chemistry, vol. 31 no. 3 (March, 1988), pp. 671-7 .

    Renin inhibitors 2-4 with the D-Lys renin inhibitory peptide (RIP) sequence, but containing Leu psi[CH2O]Ala (2), Leu psi[CH2O]Val (3), and Leu psi[CH2O]Leu (4) at the P1-P1' site, were of a comparable potency to RIP. N-Terminal Boc-protected inhibitors containing Pro psi[CH2O]Phe in positions P4-P3 were potent inhibitors of renin, with Boc-Phe-Pro psi[CH2O]Phe-His-Leu psi[CH(OH)CH2]Val-Ile-(2-aminomethyl) pyridine (17) having an IC50 of 1.6 X 10(-9) M.