Publications [#268847] of G. Allan Johnson

Papers Published
  1. Shofer, S; Badea, C; Auerbach, S; Schwartz, DA; Johnson, GA, A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice., Experimental Lung Research, vol. 33 no. 3-4 (April, 2007), pp. 169-183 [17558678], [doi] .

    Micro-computed tomography (microCT) is being increasingly used to examine small animal models of pulmonary injury. The authors have developed a microCT technique suitable for the determination of pulmonary compliance in injured mice. Lung volumes in normal mice were radiographically determined at end-inspiration and end-expiration and pulmonary compliance was calculated at 2 time points 2 weeks apart, whereas a second group of mice were given bleomycin and imaged 3 weeks following drug administration. Compliance measurements were validated using a commercially available ventilator system. MicroCT pulmonary compliance measurements are suitable for longitudinal measurements, and correlate with physiologic measurements of pulmonary compliance.