Publications [#304571] of Daniel J Gauthier

Papers Published
  1. Hall, GM; Bahar, S; Gauthier, DJ, Prevalence of rate-dependent behaviors in cardiac muscle, Physical Review Letters, vol. 82 no. 14 (1999), pp. 2995-2998 .

    We explore the rate-dependent dynamic response of periodically paced bullfrog (Rana catesbeiana) cardiac muscle. Alternans (2:2 behavior) occur in 35% of animals and 2:1 ↔ 1:1 bistability in 74% of animals. In addition, we observe 2:2 ↔ 2:1 bistablility. We discuss the implications of these results for two map-based models of cardiac dynamics. The high prevalence of bistability suggests that this dynamical behavior must be accounted for in the design of closed-loop feedback protocols to stabilize cardiac dynamics. © 1999 The American Physical Society.