Martin Fischer, Associate Research Professor of Chemistry and Physics and Faculty Network Member of Duke Institute for Brain Sciences  

Martin Fischer

Office Location: 2216 Physics
Office Phone: (919) 660-1523
Email Address: martin.fischer@duke.edu

Education:
PhD Physics, The University of Texas at Austin, 2001
Ph.D., University of Texas at Austin, 2001
M.A. in Physics, The University of Texas at Austin, 1993
M.A., University of Texas at Austin, 1993
‘Vordiplom’, The University of Freiburg, Germany, 1991

Research Description: Dr. Fischer’s research focuses on exploring novel nonlinear optical contrast mechanisms for molecular imaging. Nonlinear optical microscopes can provide non-invasive, high-resolution, 3-dimensional images even in highly scattering environments such as biological tissue. Established contrast mechanisms, such as two-photon fluorescence or harmonic generation, can image a range of targets (such as autofluorescent markers or some connective tissue structure), but many of the most molecularly specific nonlinear interactions are harder to measure with power levels one might be willing to put on tissue. In order to use these previously inaccessible interactions as structural and molecular image contrasts we are developing ultrafast laser pulse shaping and pulse shape detection methods that dramatically enhance measurement sensitivity. Applications of these microscopy methods range from imaging biological tissue (mapping structure, endogenous tissue markers, or exogenous contrast agents) to characterization of nanomaterials (such as graphene and gold nanoparticles). The molecular contrast mechanisms we originally developed for biomedical imaging also provide pigment-specific signatures for paints used in historic artwork. Recently we have demonstrated that we can noninvasively image paint layers in historic paintings and we are currently developing microscopy techniques for use in art conservation and conservation science.

Recent Publications   (More Publications)

  1. Wilson, JW; Robles, FE; Deb, S; Warren, WS; Fischer, MC, Comparison of pump-probe and hyperspectral imaging in unstained histology sections of pigmented lesions., Biomedical Optics Express, vol. 8 no. 8 (August, 2017), pp. 3882-3890 [doi]  [abs].
  2. Robles, FE; Deb, S; Fischer, MC; Warren, WS; Selim, MA, Label-Free Imaging of Female Genital Tract Melanocytic Lesions With Pump-Probe Microscopy: A Promising Diagnostic Tool., Journal of Lower Genital Tract Disease, vol. 21 no. 2 (April, 2017), pp. 137-144 [doi]  [abs].
  3. Robles, FE; Zhou, KC; Fischer, MC; Warren, WS, Stimulated Raman scattering spectroscopic optical coherence tomography, Optica, vol. 4 no. 2 (February, 2017), pp. 243-243 [doi]  [abs].
  4. Villafana, TE; Delaney, JK; Warren, WS; Fischer, MC, High-resolution, three-dimensional imaging of pigments and support in paper and textiles, Journal of Cultural Heritage, vol. 20 (July, 2016), pp. 583-588 [doi] .
  5. Warren, WS; Robles, F; Fischer, M; Wilson, J; Deb, S; Ju, K; Degan, S; Warren, WS; Robles, F; Fischer, M; Wilson, J; Deb, S; Ju, K; Degan, S, Melanin-targeted nonlinear microscopy for label-free molecular diagnosis and stagingMelanin-targeted nonlinear microscopy for label-free molecular diagnosis and staging, Optics InfoBase Conference Papers, vol. Part F19-Translational 2016 (April, Preprint, 2016) [doi]  [abs].

Highlight:
Dr. Fischer’s research focuses on exploring novel nonlinear optical contrast mechanisms for molecular imaging. Nonlinear optical microscopes can provide non-invasive, high-resolution, 3-dimensional images even in highly scattering environments such as biological tissue. Established contrast mechanisms, such as two-photon fluorescence or harmonic generation, can image a range of targets (such as autofluorescent markers or some connective tissue structure), but many of the most molecularly specific nonlinear interactions are harder to measure with power levels one might be willing to put on tissue. In order to use these previously inaccessible interactions as structural and molecular image contrasts we are developing ultrafast laser pulse shaping and pulse shape detection methods that dramatically enhance measurement sensitivity. Applications of these microscopy methods range from imaging biological tissue (mapping structure, endogenous tissue markers, or exogenous contrast agents) to characterization of nanomaterials (such as graphene and gold nanoparticles). The molecular contrast mechanisms we originally developed for biomedical imaging also provide pigment-specific signatures for paints used in historic artwork. Recently we have demonstrated that we can noninvasively image paint layers in historic paintings and we are currently developing microscopy techniques for use in art conservation and conservation science.