Publications [#232097] of Patrick Charbonneau

Papers Published
  1. Charbonneau, P; Jean-Claude, B; Whitehead, MA, Synthesis of a prodrug: A semi-empirical PM3 study, Journal of Molecular Structure: Theochem, vol. 574 (2001), pp. 85-91 [doi] .

    The semi-empirical PM3 method is used to investigate the synthesis of a prodrug of type I which can regenerate the short-lived anti-tumoral tetrazepinone. The reaction pathway examined involves four consecutive steps: the ring opening of benzo-tetrazepinone (1 → 2), the diazonium coupling (2 → 3), the double-proton transfer (4 → 6) and the dissociation (7 → 8). Geometry PM3 optimisation of all starting material, reaction intermediates and products lead to a qualitative study of this solvent-dependent synthesis. Energetics and substituent effects are analysed using a simple electron-withdrawing, electron-donating argument based on calculated Hammett constants. © 2001 Published by Elsevier Science B.V.