Publications [#234286] of Warren S. Warren

Journal Articles
  1. Theis, T; Truong, ML; Coffey, AM; Shchepin, RV; Waddell, KW; Shi, F; Goodson, BM; Warren, WS; Chekmenev, EY, Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization., Journal of the American Chemical Society, vol. 137 no. 4 (February, 2015), pp. 1404-1407 [doi] .

    Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to nitrogen-15 in pyridine and nicotinamide (vitamin B(3) amide) by conducting "signal amplification by reversible exchange" (SABRE) at microtesla fields within a magnetic shield. Following transfer of the sample from the magnetic shield chamber to a conventional NMR spectrometer, the (15)N NMR signals for these molecules are enhanced by ∼30,000- and ∼20,000-fold at 9.4 T, corresponding to ∼10% and ∼7% nuclear spin polarization, respectively. This method, dubbed "SABRE in shield enables alignment transfer to heteronuclei" or "SABRE-SHEATH", promises to be a simple, cost-effective way to hyperpolarize heteronuclei. It may be particularly useful for in vivo applications because of longer hyperpolarization lifetimes, lack of background signal, and facile chemical-shift discrimination of different species.