Publications [#235003] of Weitao Yang

Journal Articles
  1. Kasper, AC; Moon, EJ; Hu, X; Park, Y; Wooten, CM; Kim, H; Yang, W; Dewhirst, MW; Hong, J, Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations., Bioorganic & Medicinal Chemistry Letters, vol. 19 no. 14 (July, 2009), pp. 3783-3786 [19423348], [doi] .

    We have shown that manassantin A downregulated the HIF-1alpha expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.