Zhen-Ming Pei, Associate Professor  

Zhen-Ming Pei

My laboratory is interested in the early signaling events by which plants sense environmental signals and decode to give the appropriate responses. Upon perception of external signals, cell surface receptors trigger an increase in cytosolic free calcium concentration, which is mediated by ion channels. Our long-term goals are to identify these receptors and ion channels, isolate their interacting components, and assign molecular functions to them. Currently, we are using multidisciplinary approaches of biophysics, biochemistry, cell biology, molecular genetics, and function genomics to dissect the signaling cascades of external calcium as well as nitric oxide in the model plant Arabidopsis.

Education:
Ph.D., Shanghai Institute of Plant Physiology, 1993
M.S., Fudan University (China), 1990
B.S., Lanzhou University (China), 1985

Office Location: 3102 Ffsc, Duke University, Durham, NC 27708-1000
Office Phone: (919) 613-8152
Email Address: zpei@duke.edu

Specialties:
Cell and Molecular Biology
Genetics
Developmental Biology
Biophysics
Genomics

Research Categories: Plant Sensory Signal Transduction

Current projects: External calcium and nitric oxide signaling in Arabidopsis

Research Description: My laboratory is interested in the early signaling events by which plants sense environmental signals and decode to give the appropriate responses. Upon perception of external signals, cell surface receptors trigger an increase in cytosolic free calcium concentration, which is mediated by ion channels. Our long-term goals are to identify these receptors and ion channels, isolate their interacting components, and assign molecular functions to them. Currently, we are using multidisciplinary approaches of biophysics, biochemistry, cell biology, molecular genetics, and function genomics to dissect the signaling cascades of external calcium as well as nitric oxide in the model plant Arabidopsis.

Areas of Interest:
Calcium-mediated sensory process
Nitric oxide signaling
ABA signaling
Guard cell biology
Electrophysiology

Representative Publications   (More Publications)   (search)

  1. RH Tang, S Han, H Zheng, CW Cook, CS Choi, TE Woerner, RB Jackson and ZM Pei, Coupling diurnal cytosolic Ca2+ oscillations to the CAS-IP3 pathway in Arabidopsis., Science, vol. 315 no. 5817 (March, 2007), pp. 1423-1426 [17347443], [doi]  [abs].
  2. ZM Pei and K Kuchitsu, Early ABA signaling events in guard cells, Journal of Plant Growth Regulation, vol. 24 no. 4 (2005), pp. 296-307 [pdf], [doi]  [abs].
  3. Y He, RH Tang, Y Hao, RD Stevens, CW Cook, SM Ahn, L Jing, Z Yang, L Chen, F Guo, F Fiorani, RB Jackson, NM Crawford and ZM Pei, Nitric oxide represses the Arabidopsis floral transition., Science, vol. 305 no. 5692 (September, 2004), pp. 1968-1971 [15448272], [doi]  [abs].
  4. S Han, R Tang, LK Anderson, TE Woerner and ZM Pei, A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells., Nature, vol. 425 no. 6954 (2003), pp. 196-200 [12968184], [doi]  [abs].
  5. ZM PEI, Calcium channels activated by hydrogen peroxide mediate abscisic acid signaling in guard cells, Nature, vol. 406 (2000), pp. 731-734 [pdf], [doi] .
  6. ZM Pei, VM Baizabal-Aguirre, GJ Allen and JI Schroeder, A transient outward-rectifying K+ channel current down-regulated by cytosolic Ca2+ in Arabidopsis thaliana guard cells, Proceedings of the National Academy of Sciences of the United States of America, vol. 95 no. 11 (1998), pp. 6548-6553 [pdf], [doi]  [abs].
  7. ZM Pei, M Ghassemian, CM Kwak, P McCourt and JI Schroeder, Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss, Science, vol. 282 no. 5387 (1998), pp. 287-290 [pdf], [doi]  [abs].
  8. Z-M Pei, K Kuchitsu, JM Ward, M Schwarz and JI Schroeder, Differential abscisic acid regulation of guard cell slow anion channels in arabidopsis wild-type and abi1 and abi2 mutants, Plant Cell, vol. 9 no. 3 (1997), pp. 409-423 [pdf], [doi]  [abs].
  9. ZM Pei, JM Ward, JF Harper and JI Schroeder, A novel chloride channel in Vicia faba guard cell vacuoles activated by the serine/threonine kinase, CDPK, EMBO Journal, vol. 15 no. 23 (1996), pp. 6564-6574 [picrender.fcgi]  [abs].