Alvin L. Crumbliss, University Distinguished Service Professor Emeritus of Chemistry and Arts & Sciences and Bass Fellow of Chemistry
 - Contact Info:
Office Location: | 2104 French Family Science Center, Box 90346, Durham, NC 27708-0354 | Office Phone: | (919) 660-1540 | Email Address: |  |
Web Page: | http://sites.duke.edu/crumbliss/ |
- Education:
- Ph.D. Northwestern University 1968
- B.A. Knox College 1964
- A.B. with College Honors Knox College 1964
- Specialties:
-
Inorganic
Biomolecular Structure and Function
- Research Interests:
Dr. Crumbliss is a coordination chemist who
studies the function, reactivity and mobility of
transition metals in biological systems. A
major emphasis in his lab currently is
investigations related to the biochemistry of
iron. Through application of kinetic,
spectroscopic and electrochemical
techniques the Crumbliss group is
investigating low molecular weight iron
carriers (siderophores and synthetic
siderophore mimics) and high molecular
weight iron carriers (mammalian and
bacterial transferrin proteins) with respect to
their ability to mobilize and deposit iron at
specific sites in a biological system. The
structure/function role of iron in heme
proteins, such as the hemoglobins and
myoglobins, is under investigation. Synthetic
materials for metal-specific chelation
designed using principles learned from
biology are under investigation.
- Curriculum Vitae
- Recent Publications
(More Publications)
- Strader, MB; Bangle, R; Parker Siburt, CJ; Varnado, CL; Soman, J; Benitez Cardenas, AS; Samuel, PP; Singleton, EW; Crumbliss, AL; Olson, JS; Alayash, AI, Engineering oxidative stability in human hemoglobin based on the Hb providence (βK82D) mutation and genetic cross-linking.,
The Biochemical journal, vol. 474 no. 24
(December, 2017),
pp. 4171-4192 [doi] [abs].
- Gupta, A; Pratt, RD; Crumbliss, AL, Ferrous iron content of intravenous iron formulations.,
BioMetals, vol. 29 no. 3
(June, 2016),
pp. 411-415 [doi] [abs].
- Crumbliss, AL; Franz, KJ; Thiele, DJ, Preface,
BioMetals, vol. 28 no. 3
(June, 2015),
pp. 431-431 [doi].
- Banerjee, S; Weerasinghe, AJ; Parker Siburt, CJ; Kreulen, RT; Armstrong, SK; Brickman, TJ; Lambert, LA; Crumbliss, AL, Bordetella pertussis FbpA binds both unchelated iron and iron siderophore complexes.,
Biochemistry, vol. 53 no. 24
(June, 2014),
pp. 3952-3960 [doi] [abs].
- Mollan, TL; Jia, Y; Banerjee, S; Wu, G; Kreulen, RT; Tsai, A-L; Olson, JS; Crumbliss, AL; Alayash, AI, Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin.,
Free Radical Biology & Medicine, vol. 69
(April, Accepted, 2014),
pp. 265-277 [doi] [abs].
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