Faculty Database System- Arts & Sciences and Trinity College

Alvin L. Crumbliss, University Distinguished Service Professor Emeritus of Chemistry and Arts & Sciences and Bass Fellow of Chemistry

Office Location:	2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Office Phone:	(919) 660-1540
Email Address:
Web Page:	http://sites.duke.edu/crumbliss/

Education:: Ph.D. Northwestern University 1968; B.A. Knox College 1964; A.B. with College Honors Knox College 1964

Research Interests:: Dr. Crumbliss is a coordination chemist who studies the function, reactivity and mobility of transition metals in biological systems. A major emphasis in his lab currently is investigations related to the biochemistry of iron. Through application of kinetic, spectroscopic and electrochemical techniques the Crumbliss group is investigating low molecular weight iron carriers (siderophores and synthetic siderophore mimics) and high molecular weight iron carriers (mammalian and bacterial transferrin proteins) with respect to their ability to mobilize and deposit iron at specific sites in a biological system. The structure/function role of iron in heme proteins, such as the hemoglobins and myoglobins, is under investigation. Synthetic materials for metal-specific chelation designed using principles learned from biology are under investigation.

Recent Publications (More Publications)

Harrington, JM; Mysore, MM; Crumbliss, AL, The kinetics of dimethylhydroxypyridinone interactions with iron(iii) and the catalysis of iron(iii) ligand exchange reactions: implications for bacterial iron transport and combination chelation therapies., Dalton Transactions (Cambridge, England : 2003), vol. 47 no. 20 (May, 2018), pp. 6954-6964 [doi] [abs].
Strader, MB; Bangle, R; Parker Siburt, CJ; Varnado, CL; Soman, J; Benitez Cardenas, AS; Samuel, PP; Singleton, EW; Crumbliss, AL; Olson, JS; Alayash, AI, Engineering oxidative stability in human hemoglobin based on the Hb providence (βK82D) mutation and genetic cross-linking., The Biochemical Journal, vol. 474 no. 24 (December, 2017), pp. 4171-4192 [doi] [abs].
Crumbliss, AL, Aqueous solution equilibrium and kinetic studies of iron siderophore and model siderophore complexes, in Handbook of Microbial Iron Chelates (1991) (January, 2017), pp. 177-234 [doi] [abs].
Gupta, A; Pratt, RD; Crumbliss, AL, Ferrous iron content of intravenous iron formulations., Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, vol. 29 no. 3 (June, 2016), pp. 411-415 [doi] [abs].
Crumbliss, AL; Franz, KJ; Thiele, DJ, Preface, Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, vol. 28 no. 3 (June, 2015), pp. 431-431 [doi].