Alvin L. Crumbliss, University Distinguished Service Professor Emeritus
- Contact Info:
Office Location: | 2104 French Family Science Center, Box 90346, Durham, NC 27708-0354 | Office Phone: | (919) 660-1540 | Email Address: | |
Web Page: | http://sites.duke.edu/crumbliss/ |
- Education:
- Ph.D. Northwestern University 1968
- B.A. Knox College 1964
- A.B. with College Honors Knox College 1964
- Specialties:
-
Inorganic
Biomolecular Structure and Function
- Research Interests:
Dr. Crumbliss is a coordination chemist who
studies the function, reactivity and mobility of
transition metals in biological systems. A
major emphasis in his lab currently is
investigations related to the biochemistry of
iron. Through application of kinetic,
spectroscopic and electrochemical
techniques the Crumbliss group is
investigating low molecular weight iron
carriers (siderophores and synthetic
siderophore mimics) and high molecular
weight iron carriers (mammalian and
bacterial transferrin proteins) with respect to
their ability to mobilize and deposit iron at
specific sites in a biological system. The
structure/function role of iron in heme
proteins, such as the hemoglobins and
myoglobins, is under investigation. Synthetic
materials for metal-specific chelation
designed using principles learned from
biology are under investigation.
- Curriculum Vitae
- Recent Publications
(More Publications)
- Crumbliss, AL; Banerjee, S, A perspective essay on the use of Ga3+ as a proxy for Fe3+ in bioinorganic model studies and its successful use for therapeutic purposes.,
Journal of Inorganic Biochemistry, vol. 219
(June, 2021),
pp. 111411 [doi] [abs].
- Ghio, AJ; Soukup, JM; Dailey, LA; Roggli, VL; Crumbliss, AL; Palmer, SM, Diacetyl exposure disrupts iron homeostasis in animals and cells.,
Inhal Toxicol, vol. 33 no. 6-8
(2021),
pp. 268-274 [doi] [abs].
- Ciferri, A; Crumbliss, AL, Supramolecular and Liquid Crystalline Contributions to the Assembly of Myofibril.,
Molecules (Basel, Switzerland), vol. 25 no. 4
(February, 2020),
pp. E862 [doi] [abs].
- Ciferri, A; Crumbliss, AL, A Supramolecular Polymerization Approach to the Growth of the Myofibril.,
Frontiers in Chemistry, vol. 7
(January, 2019),
pp. 487 [doi] [abs].
- Harrington, JM; Mysore, MM; Crumbliss, AL, The kinetics of dimethylhydroxypyridinone interactions with iron(iii) and the catalysis of iron(iii) ligand exchange reactions: implications for bacterial iron transport and combination chelation therapies.,
Dalton Transactions (Cambridge, England : 2003), vol. 47 no. 20
(May, 2018),
pp. 6954-6964 [doi] [abs].
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