Publications [#335240] of Daniel P. Kiehart

Papers Published

1. Lo, W-C; Madrak, C; Kiehart, DP; Edwards, GS, Unified biophysical mechanism for cell-shape oscillations and cell ingression., Physical review. E, vol. 97 no. 6-1 (June, 2018), pp. 062414 [doi]
   (last updated on 2024/04/19)

   Abstract:
   We describe a mechanochemical and percolation cascade that augments myosin's regulatory network to tune cytoskeletal forces. Actomyosin forces collectively generate cytoskeletal forces during cell oscillations and ingression, which we quantify by elastic percolation of the internally driven, cross-linked actin network. Contractile units can produce relatively large, oscillatory forces that disrupt crosslinks to reduce cytoskeletal forces. A (reverse) Hopf bifurcation switches contractile units to produce smaller, steady forces that enhance crosslinking and consequently boost cytoskeletal forces to promote ingression. We describe cell-shape changes and cell ingression in terms of intercellular force imbalances along common cell junctions.

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