Katia Koelle, Associate Professor of Biology

Katia Koelle
Office Location:  130 Science Drive
Office Phone:  (919) 660-9457
Email Address: send me a message
Web Page:  http://www.biology.duke.edu/koellelab/index.html

Teaching (Fall 2015):


PhDUniversity of Michigan- Ann Arbor2005
BSStanford University1997

Ecology and Population Biology
Research Interests: Theoretical biology; ecology and evolution of infectious diseases

My research focuses on the ecology and evolution of infectious diseases. I use a combination of mathematical and statistical approaches to understand the processes that give rise to the dynamic and evolutionary patterns of pathogens. More specifically, my interests fall into three main areas: 1) The regulation of infectious disease dynamics, 2) The determinants of genetic and antigenic diversity patterns in pathogen populations, and 3) Pathogen adaptation to environmental change. The systems I have worked most closely with include Vibrio cholerae (the bacterium that causes cholera) and influenza. Most of my current research focuses on the development of quantitative models to further our understanding of rapidly-mutating RNA viruses.

Current Ph.D. Students  

  • Rotem Ben-Shachar  
  • Ashley Sobel  
  • Stacy Scholle  
  • David A. Rasmussen  
Postdocs Mentored

  • Jayna Raghwani (February, 2012 - February, 2013)  
  • Oliver Ratmann (October, 2009 - July, 2012)  
  • Virginia Pasour (August, 2008 - October, 2009)  
Recent Publications

  1. Luo, S. and K. Koelle, Navigating the devious course of evolution: the importance of mechanistic models for identifying eco-evolutionary dynamics in nature, The American Naturalist, vol. 181 no. S58-S75 (2013)
  2. Wu, S., Koelle, K., and A. Rodrigo, Coalescent entanglement: conditional dependence of the times-to-common-ancestry of mutually exclusive pairs of individuals, Journal of Heredity, vol. 104 no. 1 (2013), pp. 86-91
  3. Volz, E.M., Koelle, K., Bedford, T., Viral phylodynamics, PLoS Computational Biology, vol. 9 no. 3 (2013), pp. e1002947
  4. Yuan, H., Koelle, K., The evolutionary dynamics of receptor binding avidity in influenza A: a mathematical model for a new antigenic drift hypothesis, Philosophical Transactions of the Royal Society B., vol. 368 no. 1614 (2013), pp. 20120204
  5. Scholle, S.O., Ypma, R., Lloyd, A.L., Koelle, K., Viral substitution rate variation can arise from the interplay between within-host and epidemiological dynamicssubstitution rates, The American Naturalist, vol. 182 no. 4 (2013), pp. 494-513 [doi]