Publications [#89924] of Thomas B Kepler

Papers Published

1. M Zavolan, TB Kepler, Statistical inference of sequence-dependent mutation rates., Current opinion in genetics & development, England, vol. 11 no. 6 (December, 2001), pp. 612-5, ISSN 0959-437X
   (last updated on 2006/02/08)

   Abstract:
   Several lines of research are now converging towards an integrated understanding of mutational mechanisms and their evolutionary implications. Experimentally, crystal structures reveal the effect of sequence context on polymerase fidelity; large-scale sequencing projects generate vast amounts of sequence polymorphism data; and locus-specific databases are being constructed. Computationally, software and analytical tools have been developed to analyze mutational data, to identify mutational hot spots, and to compare the signatures of mutagenic agents.

   Keywords:
   Computational Biology • Databases, Factual • Genome, Human • Humans • Molecular Sequence Data • Mutation* • Sequence Analysis, DNA • Statistics* • Variation (Genetics) • standards* • trends*