Publications [#89949] of Thomas B Kepler

Papers Published

1. SA Fadel, LG Cowell, S Cao, DA Ozaki, TB Kepler, DA Steeber, M Sarzotti, Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection., International immunology, England, vol. 18 no. 2 (February, 2006), pp. 249-57, ISSN 0953-8178
   (last updated on 2006/02/08)

   Abstract:
   Immunizations early in life, when the host is most susceptible to infection, allow protective immunological memory to develop. Decreasing the dose of Cas-Br-E murine leukemia virus when priming neonatal mice results in adult-like, Type 1 protective responses, but the resulting memory cell populations are smaller than after adult priming. After secondary challenge, virus-specific CD8+ memory cell populations expand twice as much in neonate-primed mice as in adult-primed mice. We found that when equivalent numbers of virus-specific cells were transferred into virus-susceptible mice, protection from disease was similar whether donor, immune mice were primed as neonates or adults, and IL-4 did not alter in vivo virus-specific CD8+ memory cell effector function. Hence, neonate-primed CD8+ cells develop into memory cells that rival adult-primed cells in proliferation and effector function.

   Keywords:
   Animals • Animals, Newborn • Antibodies, Viral • Antigens, Viral • CD8-Positive T-Lymphocytes • Cytotoxicity, Immunologic • Immunity, Cellular • Immunization, Secondary • Immunologic Memory* • Interleukin-4 • Leukemia Virus, Murine • Leukemia, Experimental • Mice • Retroviridae Infections • Tumor Virus Infections • immunology • immunology* • physiology • prevention & control • virology