Publications [#119513] of Darrell V Lewis Jr.
Papers Published
- DD Mott, DV Lewis, CM Ferrari, WA Wilson, HS Swartzwelder, Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus.,
Neuroscience letters, NETHERLANDS, vol. 113 no. 2
(May, 1990),
pp. 222-6, ISSN 0304-3940
(last updated on 2006/10/24)Abstract:
The effect of baclofen on the development of long-term potentiation (LTP) in the dentate gyrus was examined. Stimulus trains applied to the perforant path in the presence of baclofen produced significantly more potentiation of the perforant path-evoked response than did similar stimulation in control medium. In addition, baclofen enabled stimulus trains, ordinarily subthreshold for LTP induction, to produce LTP. These results demonstrate that GABAB receptor activation by baclofen makes repetitive stimulation more effective at producing LTP.Keywords:
Action Potentials • Animals • Baclofen • Electric Stimulation • Hippocampus • Male • Neuronal Plasticity • Rats • Rats, Inbred Strains • drug effects • drug effects* • pharmacology* • physiology*