Publications [#119520] of Darrell V Lewis Jr.
Papers Published
- DV Lewis, KL Zbicz, ME Nepp, WF Colmers, WA Wilson, Diphenylhydantoin enhances early adaptation in Aplysia giant neurons.,
The Journal of pharmacology and experimental therapeutics, UNITED STATES, vol. 218 no. 1
(July, 1981),
pp. 41-5, ISSN 0022-3565
(last updated on 2006/10/24)Abstract:
Diphenylhydantoin effect on excitability in the molluscan giant neuron was investigated. This model of neuronal excitability was convenient for investigating drug mechanisms because the giant somata of these neurons have multiple current systems and can be voltage clamped. Current and voltage clamp methods were used to quantitate firing frequency and the slow membrane currents associated with changes in firing rate. Diphenylhydantoin enhanced the early rapid deceleration of firing of the cell in response to depolarizing current and blocked an early show inward current.Keywords:
Action Potentials • Adaptation, Physiological • Animals • Aplysia • Electrophysiology • Neurons • Phenytoin • drug effects • drug effects* • pharmacology*