CNCS Center for Nonlinear and Complex Systems
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Patrick D. Wolf, Associate Professor of Biomedical Engineering and CNCS: Center for nonlinear and complex systems

Patrick D. Wolf

My research is primarily in the area of advanced instrumentation for diagnosis and treatment of electrophysiological problems. This research covers two primary organ systems: the heart and the brain.

One thrust of the cardiac-based work is centered on atrial fibrillation and in particular on very low energy atrial defibrillation strategies. The goal is to produce a device that can defibrillate the atria with a painless series of electrical impulses. A second area of interest is the study of the biophysics of radio frequency ablation of the heart. A third avenue of research in the cardiac area is the development of new instruments and techniques for tracking interventional devices within the body without the use of ionizing radiation. These devices primarily rely on ultrasound technology. There is a strong collaborative effort in this area with the Duke Ultrasound group in the Department of Biomedical Engineering. The long term goal of this work is to develop technology to deliver image-guided therapy to target tissues in the heart and other organs.

In neuroengineering, we are currently developing a "brainchip" that would telemeter information recorded directly from neurons in the brain to a remote device. This IC based technology is being developed for application in neuro-prosthetic or brain controlled devices. There is a close collaboration on this project between our lab and the laboratory of Dr. Miguel Nicolelis the Department of Neurobiology. We are also developing advanced neural recoding systems to use on unrestrained, untethered animals as they learn to perform certain tasks.

Contact Info:
Office Location:  Rm. 276, Hudson Annex, Durham, NC 27708
Office Phone:  (919) 660-5114
Email Address: send me a message
Web Page:  http://www.math.duke.edu/cncs/~pdw

Teaching (Spring 2016):

  • BME 506.01, CARDIAC ELEC EVENTS Synopsis
    Hudson 139, MW 01:25 PM-02:40 PM
Teaching (Fall 2016):

  • BME 464L.001, MEDICAL INSTRUMENT DSGN Synopsis
    Hudson 139, MW 10:05 AM-11:20 AM
  • BME 464L.01L, MEDICAL INSTRUMENT DSGN Synopsis
    Teer P012, M 04:40 PM-07:40 PM
Education:

Ph.D.Duke University1992
MSPennsylvania State University1986
BSPennsylvania State University1978
Specialties:

Medical Instrumentation
Heart, Electrophysiology
Neural Prosthesis
Neuroengineering
Research Interests:

Current projects: Image Guided Ablation Therapy, Fully Implanted Brain-Machine Interface

Wolf's research is primarily in the area of advanced instrumentation for diagnosis and treatment of electrophysiological problems. This research covers two primary organ systems: the heart and the brain. In the heart, Dr. Wolf is developing an image guided ablation system for treatment of arrhythmias. In the brain, he is developing a fully implantable Brain-Machine interface.

Areas of Interest:

Cardiac Arrhythmias
Pacing
Defibrillation
Brian-Machine Interface
Neural Coding

Keywords:

Ablation • Action Potentials • Age Factors • Aging • Algorithms • Amplifiers, Electronic • Analog-Digital Conversion • Analysis of Variance • Animals • Anisotropy • Anterior Cerebral Artery • Arrhythmias, Cardiac • Artifacts • Atrial Fibrillation • Atrial Function • Bias (Epidemiology) • Biomechanics • Biomedical Engineering • Biophysics • Biopsy • Blood Flow Velocity • Blood Physiological Phenomena • Blood Pressure • Body Surface Potential Mapping • Bradycardia • Brain • Brain Neoplasms • Brain-Machine Interface • Calcium Channels • Cardiac Catheterization • Cardiac Complexes, Premature • Cardiac Pacing, Artificial • Cardiac Surgical Procedures • Cardiac Volume • Cardiac-Gated Imaging Techniques • Cardiovascular System • Carotid Artery, Internal • Catheter Ablation • Catheterization • Catheters • Cattle • Cell Culture Techniques • Cell Differentiation • Cell Division • Cell Lineage • Cerebral Angiography • Cerebral Cortex • Cerebral Ventricles • Cerebrovascular Circulation • Computer Simulation • Computer Systems • Computers • Contrast Media • Coronary Circulation • Coronary Sinus • Data Compression • Defibrillators, Implantable • Diagnosis, Computer-Assisted • Diagnosis, Differential • Diagnostic Imaging • Differential Threshold • Disease Models, Animal • Disease Susceptibility • Dogs • Dose-Response Relationship, Radiation • Echocardiography • Echocardiography, Doppler • Echocardiography, Doppler, Color • Echocardiography, Three-Dimensional • Echocardiography, Transesophageal • Echoencephalography • Elastic Modulus • Elasticity • Elasticity Imaging Techniques • Electric Conductivity • Electric Countershock • Electric Impedance • Electric Stimulation • Electricity • Electrocardiography • Electrodes • Electrodes, Implanted • Electroencephalography • Electromyography • Electronics, Medical • Electrophysiologic Techniques, Cardiac • Electrophysiology • Electroshock • Endocardium • Equipment Design • Equipment Failure Analysis • Evaluation Studies as Topic • Evoked Potentials • Extracellular Space • Feasibility Studies • Female • Fiber Optic Technology • Finite Element Analysis • Fluoroscopy • Fourier Analysis • Functional Laterality • Glioblastoma • Haplorhini • Heart • Heart Atria • Heart Block • Heart Conduction System • Heart Diseases • Heart Rate • Heart Ventricles • Hot Temperature • Humans • Hyperthermia, Induced • Image Enhancement • Image Interpretation, Computer-Assisted • Image Processing, Computer-Assisted • Imaging, Three-Dimensional • Incidence • Information Storage and Retrieval • Intraoperative Care • Intraoperative Period • Isoproterenol • Jugular Veins • Laparoscopes • Laparoscopy • Laryngeal Muscles • Least-Squares Analysis • Linear Models • Liver • Logistic Models • Lung • Macaca mulatta • Magnetic Resonance Angiography • Magnetic Resonance Imaging • Male • Man-Machine Systems • Mathematics • Membrane Potentials • Mice • Mice, Nude • Microelectrodes • Middle Aged • Miniaturization • Models, Anatomic • Models, Animal • Models, Biological • Models, Cardiovascular • Models, Neurological • Models, Statistical • Models, Theoretical • Movement • Muscle Fibers, Skeletal • Myoblasts, Skeletal • Myocardial Contraction • Myocardial Infarction • Myocardium • Myocytes, Cardiac • Necrosis • Nerve Fibers • Nerve Net • Neurons • Optical Fibers • Organ Specificity • Pacemaker, Artificial • Pattern Recognition, Automated • Pericardium • Phantoms, Imaging • Pilot Projects • Polyimides • Polysaccharides • Posture • Predictive Value of Tests • Probability • Prognosis • Propranolol • Prostheses and Implants • Pulmonary Veins • Punctures • Quality Control • Rabbits • Radio Waves • Rats • Reaction Time • Refractometry • Refractory Period, Electrophysiological • Regression Analysis • Reproducibility of Results • Rheology • Robotics • Semiconductors • Sensitivity and Specificity • Shear Strength • Sheep • Sheep, Domestic • Signal Processing, Computer-Assisted • Skin • Sodium Channels • Somatosensory Cortex • Statistics as Topic • Stress, Mechanical • Stroke Volume • Surgery, Computer-Assisted • Swine • Synaptic Transmission • Systems Integration • Systole • Tachycardia • Tachycardia, Ventricular • Telemetry • Temperature • Tetrodotoxin • Thermal Conductivity • Thorax • Time Factors • Tissue Engineering • Transducers • Treatment Outcome • Ultrasonic transducers • Ultrasonography • Ultrasonography, Doppler • Ultrasonography, Doppler, Color • Ultrasonography, Interventional • User-Computer Interface • Vagus Nerve • Vena Cava, Superior • Ventricular Fibrillation • Ventricular Function • Ventricular Function, Left • Verapamil • Vibration

Recent Publications   (More Publications)

  1. SA Eyerly, M Vejdani-Jahromi, DM Dumont, GE Trahey and PD Wolf, The Evolution of Tissue Stiffness at Radiofrequency Ablation Sites During Lesion Formation and in the Peri-Ablation Period., Journal of cardiovascular electrophysiology (May, 2015), ISSN 1045-3873 [doi]  [abs]
  2. M Vejdani-Jahromi, M Nagle, GE Trahey and PD Wolf, Ultrasound shear wave elasticity imaging quantifies coronary perfusion pressure effect on cardiac compliance., IEEE transactions on medical imaging, vol. 34 no. 2 (February, 2015), pp. 465-473, ISSN 0278-0062 [doi]  [abs]
  3. TD Bahnson, SA Eyerly, PJ Hollender, JR Doherty, YJ Kim, GE Trahey and PD Wolf, Feasibility of near real-time lesion assessment during radiofrequency catheter ablation in humans using acoustic radiation force impulse imaging., Journal of cardiovascular electrophysiology, vol. 25 no. 12 (December, 2014), pp. 1275-1283, ISSN 1045-3873 [doi]  [abs]
  4. B Byram, H Kim, L Van Assche, PD Wolf and GE Trahey, The feasibility of myocardial infarct visualization using atrial kick induced strain (AKIS) contrast., Ultrasound in medicine & biology, vol. 40 no. 6 (June, 2014), pp. 1104-1117, ISSN 0301-5629 [doi]  [abs]
  5. SA Eyerly, TD Bahnson, JI Koontz, DP Bradway, DM Dumont, GE Trahey and PD Wolf, Contrast in intracardiac acoustic radiation force impulse images of radiofrequency ablation lesions., Ultrasonic imaging, vol. 36 no. 2 (April, 2014), pp. 133-148, ISSN 0161-7346 [DukeSpace], [doi]  [abs]